supported by the National Natural Science Foundation of China,Nos. 32260196 (to JY), 81860646 (to ZY) and 31860274 (to JY);a grant from Yunnan Department of Science and Technology,Nos. 202101AT070251 (to JY), 202201AS070084 (to ZY), 202301AY070001-239 (to JY), 202101AZ070001-012, and 2019FI016 (to ZY)。
Studies have shown that chitosan protects against neurodegenerative diseases. However, the precise mechanism remains poorly understood. In this study, we administered chitosan intragastrically to an MPTP-induced mouse...
supported by a grant from Ministry of Science,Technological Development and Innovation,Serbia,No.451-03-68/2022-14/200178(to NN);University of Defence,No.MFVMA/02/22-24(to MN)。
An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progress...
supported by the National Key R&D Program of China(No.2022YFC3400700);the National Natural Science Foundation of China(Nos.22074110,22277093,22207090);the Key Research and Development Project of Hubei Province,China(No.2023BCB094);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University,China(Nos.ZNJC202208,ZLJC2022001).
RNA molecules undergo a variety of modifications,including inosine modification,also called adenosine-to-inosine(A-to-I)RNA editing,which is prevalent across all domains of life.To unravel the roles of A-to-I RNA edit...
supported by the National Natural Science Foundation of China(22078132,22108103,and U22A20413);the Open Funding Project of the National Key Labora-tory of Biochemical Engineering(2021KF-02);China Postdoctoral Science Foundation(2021M691301);Jiangsu Key Research and Development Program(BE2022356);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(CPSF)(GZ20230989);Jiangsu Agricultural Independent Innovation Fund Project(CX(21)3079).
Expanding the specific surface area of substrates and carrying out precise surface engineering of imprinted nanocavities are crucial methods for enhancing the identification efficiency of molecularly imprinted polymer...
supported by the grants from the National Natural Science Foundation of China(81970503,82100670,82202021and 82270606);Chinese Institutes for Medical Research;Beijing(CX24PY16);R&D Program of Beijing Municipal Education Commission(KZ202210025036);Beijing Municipal Administration of Hospitals’Ascent Plan(DFL20220103);Beijing Nova Program(Z211100002121036);Youth Beijing Scholar(035)and the Reform and Development Program of Beijing Institute of Respiratory Medicine(Ggyfz202403);Generation of reagents and mutant mice are also supported by the National Institutes of Health(R01 DK108894;R21 CA164970 and R21 CA221702);Department of Defense Award W81XWH-16-0464。
Hepatic ischemia–reperfusion injury(HIRI)is an important cause of liver injury following liver transplantation and major resections,and neutrophils are the key effector cells in HIRI.Double-negative T regulatory cell...
Supported by the National Institutes of Health Grants,No.K99HL146954 and No.R00HL146954;the College of Pharmacy Seed Research Grant Program of the University of Tennessee Health Science Center.
The prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)has increased significantly in recent decades and is projected to increase further due to the rising obesity rates.MASLD patients are at...
Objective:To evaluate the performance parameters of adenosine triphosphat(ATP)bioluminescence detection technology in assessing surface cleanliness in surgical environments and on hand surfaces.Methods:Samples were co...
supported by grants from the State’s Key Project of Research and Development Plan(Grant No.2021YFE0110600);the National Natural Science Foundation of China(Grant Nos.82072578 and 82350121);the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(Grant No.ZYCXTD2023013)。
This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages(TAMs),a key determinant of the tumor microenvironment(TME).Adenosine is an immunosuppressive met...
In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic...
funded by the CDTI program project EXP 00137666/IDI-20210456 awarded to Caldic Ibérica S.L.;the research contract: “Desarrollo de formulados bioestimulantes y biofertilizantes innovadores de origen natural (Calbio) destinados a la agricultura convencional y ecológica. Estudio científico de efectos sinérgicos entre bioactivos microbianos y no microbianos” between Caldic Ibérica S.L. and Universitat Politècnica de València;also funded by the research project CPP2022-009965 “Modelo de evaluación de efectos de bioestimulantes en cultivos con condiciones de stress abiótico: escasez de agua y baja fertilización (MODELCALBIOSTRESS)” funded by MCIN/AEI/ 10.13039/501100011033;the “European Union Next Generation EU/PRTR”;PAID-06-22 “Evaluación del efecto beneficioso de la combinación de diferentes bioestimulantes comerciales (extractos de productos naturales y microbianos) bajo condiciones de estrés salino en plantas de interés agronómico” funded by the Universitat Politècnica de València。
Salinization poses a significant challenge in agriculture, exacerbated by anthropogenic global warming. Biostimulants, derived from living microorganisms or natural extracts, have emerged as valuable tools for convent...