ADENOSINE

作品数:290被引量:564H指数:11
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相关领域:医药卫生更多>>
相关作者:杨军朱荃李绍平詹华强季晖更多>>
相关机构:上海交通大学医学院附属新华医院中国药科大学连云港市第一人民医院重庆医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>
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Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood–brain barrier
《Neural Regeneration Research》2026年第1期377-391,共15页Yinying Wang Rongsha Chen Guolin Shi Xinwei Huang Ke Li Ruohua Wang Xia Cao Zhongshan Yang Ninghui Zhao Jinyuan Yan 
supported by the National Natural Science Foundation of China,Nos. 32260196 (to JY), 81860646 (to ZY) and 31860274 (to JY);a grant from Yunnan Department of Science and Technology,Nos. 202101AT070251 (to JY), 202201AS070084 (to ZY), 202301AY070001-239 (to JY), 202101AZ070001-012, and 2019FI016 (to ZY)。
Studies have shown that chitosan protects against neurodegenerative diseases. However, the precise mechanism remains poorly understood. In this study, we administered chitosan intragastrically to an MPTP-induced mouse...
关键词:ACETATE adenosine 5′-monophosphate-activated protein kinase blood–brain barrier CHITOSAN dopamine neurons INFLAMMATION intestinal barrier Parkinson's disease peroxisome proliferator-activated receptor delta short-chain fatty acids 
Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease
《Neural Regeneration Research》2025年第7期2053-2067,共15页Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic 
supported by a grant from Ministry of Science,Technological Development and Innovation,Serbia,No.451-03-68/2022-14/200178(to NN);University of Defence,No.MFVMA/02/22-24(to MN)。
An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progress...
关键词:A_(1)R A_(2A)R adenosine receptors ADENOSINE ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling 
Quantitative and Site-specific Analysis of Adenosine-to-inosine RNA Editing by Ligation-assisted qPCR
《Chemical Research in Chinese Universities》2025年第2期288-295,共8页TAO Wanbing GU Shuyi XIONG Jun YUAN Bifeng 
supported by the National Key R&D Program of China(No.2022YFC3400700);the National Natural Science Foundation of China(Nos.22074110,22277093,22207090);the Key Research and Development Project of Hubei Province,China(No.2023BCB094);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University,China(Nos.ZNJC202208,ZLJC2022001).
RNA molecules undergo a variety of modifications,including inosine modification,also called adenosine-to-inosine(A-to-I)RNA editing,which is prevalent across all domains of life.To unravel the roles of A-to-I RNA edit...
关键词:A-to-I RNA editing INOSINE RNA modification Quantification Site-specific detection 
Bioinspired Surface Engineering with Dual Covalent Receptors Incorporated via Precise Post-Imprinting Modification to Enhance the Specific Identification of Adenosine 5′-Monophosphate
《Engineering》2025年第2期143-154,共12页Pan Wang Tao Cheng Zhuangxin Wei Lu Liu Yue Wang Xiaohua Tian Jianming Pan 
supported by the National Natural Science Foundation of China(22078132,22108103,and U22A20413);the Open Funding Project of the National Key Labora-tory of Biochemical Engineering(2021KF-02);China Postdoctoral Science Foundation(2021M691301);Jiangsu Key Research and Development Program(BE2022356);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(CPSF)(GZ20230989);Jiangsu Agricultural Independent Innovation Fund Project(CX(21)3079).
Expanding the specific surface area of substrates and carrying out precise surface engineering of imprinted nanocavities are crucial methods for enhancing the identification efficiency of molecularly imprinted polymer...
关键词:Precise surface engineering Dual covalent receptor Precise post-imprinting modification Specific identification of adenosine 5-monophosphate 
Purinergic signaling by TCRaβ^(+)double-negative T regulatory cells ameliorates liver ischemia–reperfusion injury
《Science Bulletin》2025年第2期241-254,共14页Hua Jin Mingyang Li Xiyu Wang Lu Yang Xinjie Zhong Zihan Zhang Xiaotong Han Jingjing Zhu Mengyi Li Songlin Wang Simon C.Robson Guangyong Sun Dong Zhang 
supported by the grants from the National Natural Science Foundation of China(81970503,82100670,82202021and 82270606);Chinese Institutes for Medical Research;Beijing(CX24PY16);R&D Program of Beijing Municipal Education Commission(KZ202210025036);Beijing Municipal Administration of Hospitals’Ascent Plan(DFL20220103);Beijing Nova Program(Z211100002121036);Youth Beijing Scholar(035)and the Reform and Development Program of Beijing Institute of Respiratory Medicine(Ggyfz202403);Generation of reagents and mutant mice are also supported by the National Institutes of Health(R01 DK108894;R21 CA164970 and R21 CA221702);Department of Defense Award W81XWH-16-0464。
Hepatic ischemia–reperfusion injury(HIRI)is an important cause of liver injury following liver transplantation and major resections,and neutrophils are the key effector cells in HIRI.Double-negative T regulatory cell...
关键词:Double-negative T regulatory cells Hepatic ischemia and reperfusion injury CD39 ADENOSINE A2AR 
Fanlian Huazhuo Formula:A promising herbal preparation for metabolic liver disease被引量:1
《World Journal of Gastroenterology》2024年第46期4964-4968,共5页Bhupesh Singla 
Supported by the National Institutes of Health Grants,No.K99HL146954 and No.R00HL146954;the College of Pharmacy Seed Research Grant Program of the University of Tennessee Health Science Center.
The prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)has increased significantly in recent decades and is projected to increase further due to the rising obesity rates.MASLD patients are at...
关键词:Metabolic dysfunction-associated steatotic liver disease Fanlian Huazhuo Formula De novo lipogenesis Cell death Adenosine-5’-monophosphate-activated protein kinase alpha Acetyl-CoA carboxylase 
Study on Performance Parameters of ATP Bioluminescence Detection Technology for Hand Surface Cleanliness
《Chinese Journal of Biomedical Engineering(English Edition)》2024年第4期153-157,共5页CHEN Xiong WANG Tao LIN Zhen XIE Zhi-min CHEN Xiang 
Objective:To evaluate the performance parameters of adenosine triphosphat(ATP)bioluminescence detection technology in assessing surface cleanliness in surgical environments and on hand surfaces.Methods:Samples were co...
关键词:adenosine triphosphat(ATP)bioluminescence assay CLEANLINESS hand hygiene surgical environment INSTRUMENTS 
Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy
《Cancer Biology & Medicine》2024年第11期995-1011,共17页Lei Yang Yi Zhang Li Yang 
supported by grants from the State’s Key Project of Research and Development Plan(Grant No.2021YFE0110600);the National Natural Science Foundation of China(Grant Nos.82072578 and 82350121);the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(Grant No.ZYCXTD2023013)。
This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages(TAMs),a key determinant of the tumor microenvironment(TME).Adenosine is an immunosuppressive met...
关键词:Adenosine signaling CD39 CD73 tumor associated macrophages cancer therapy 
Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective
《World Journal of Hepatology》2024年第10期1208-1212,共5页Nabil Eid Payal Bhatnagar Li-Li Chan Marina Garcia-Macia 
In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic...
关键词:STEATOSIS Liver Xiaoyao San Inflammation ANDROGEN Adenosine 5’-monophosphate-activated protein kinase Phosphatase and tensin homolog Autophagy Lipophagy Alpha smooth muscle actin 
The combination of a microbial and a non-microbial biostimulant increases yield in lettuce(Lactuca sativa) under salt stress conditions by up-regulating cytokinin biosynthesis
《Journal of Integrative Plant Biology》2024年第10期2140-2157,共18页Patricia Benito Marina Celdrán Javier Bellón Vicente Arbona Miguel González-Guzmán Rosa Porcel Lynne Yenush José M.Mulet 
funded by the CDTI program project EXP 00137666/IDI-20210456 awarded to Caldic Ibérica S.L.;the research contract: “Desarrollo de formulados bioestimulantes y biofertilizantes innovadores de origen natural (Calbio) destinados a la agricultura convencional y ecológica. Estudio científico de efectos sinérgicos entre bioactivos microbianos y no microbianos” between Caldic Ibérica S.L. and Universitat Politècnica de València;also funded by the research project CPP2022-009965 “Modelo de evaluación de efectos de bioestimulantes en cultivos con condiciones de stress abiótico: escasez de agua y baja fertilización (MODELCALBIOSTRESS)” funded by MCIN/AEI/ 10.13039/501100011033;the “European Union Next Generation EU/PRTR”;PAID-06-22 “Evaluación del efecto beneficioso de la combinación de diferentes bioestimulantes comerciales (extractos de productos naturales y microbianos) bajo condiciones de estrés salino en plantas de interés agronómico” funded by the Universitat Politècnica de València。
Salinization poses a significant challenge in agriculture, exacerbated by anthropogenic global warming. Biostimulants, derived from living microorganisms or natural extracts, have emerged as valuable tools for convent...
关键词:abscisic acid biostimulants CYTOKININS isopentenyl adenosine LETTUCE salt stress 
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