ADENOSINE

作品数：286被引量：561H指数：11
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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease
《Neural Regeneration Research》2025年第7期2053-2067,共15页Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic 
supported by a grant from Ministry of Science,Technological Development and Innovation,Serbia,No.451-03-68/2022-14/200178(to NN);University of Defence,No.MFVMA/02/22-24(to MN)。
An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progress...
关键词：A_(1)R A_(2A)R adenosine receptors ADENOSINE ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling 
Purinergic signaling by TCRaβ^(+)double-negative T regulatory cells ameliorates liver ischemia–reperfusion injury
《Science Bulletin》2025年第2期241-254,共14页Hua Jin Mingyang Li Xiyu Wang Lu Yang Xinjie Zhong Zihan Zhang Xiaotong Han Jingjing Zhu Mengyi Li Songlin Wang Simon C.Robson Guangyong Sun Dong Zhang 
supported by the grants from the National Natural Science Foundation of China(81970503,82100670,82202021and 82270606);Chinese Institutes for Medical Research;Beijing(CX24PY16);R&D Program of Beijing Municipal Education Commission(KZ202210025036);Beijing Municipal Administration of Hospitals’Ascent Plan(DFL20220103);Beijing Nova Program(Z211100002121036);Youth Beijing Scholar(035)and the Reform and Development Program of Beijing Institute of Respiratory Medicine(Ggyfz202403);Generation of reagents and mutant mice are also supported by the National Institutes of Health(R01 DK108894;R21 CA164970 and R21 CA221702);Department of Defense Award W81XWH-16-0464。
Hepatic ischemia–reperfusion injury(HIRI)is an important cause of liver injury following liver transplantation and major resections,and neutrophils are the key effector cells in HIRI.Double-negative T regulatory cell...
关键词：Double-negative T regulatory cells Hepatic ischemia and reperfusion injury CD39 ADENOSINE A2AR 
Fanlian Huazhuo Formula:A promising herbal preparation for metabolic liver disease被引量：1
《World Journal of Gastroenterology》2024年第46期4964-4968,共5页Bhupesh Singla 
Supported by the National Institutes of Health Grants,No.K99HL146954 and No.R00HL146954;the College of Pharmacy Seed Research Grant Program of the University of Tennessee Health Science Center.
The prevalence of metabolic dysfunction-associated steatotic liver disease(MASLD)has increased significantly in recent decades and is projected to increase further due to the rising obesity rates.MASLD patients are at...
关键词：Metabolic dysfunction-associated steatotic liver disease Fanlian Huazhuo Formula De novo lipogenesis Cell death Adenosine-5’-monophosphate-activated protein kinase alpha Acetyl-CoA carboxylase 
Adenosine signaling in tumor-associated macrophages and targeting adenosine signaling for cancer therapy
《Cancer Biology & Medicine》2024年第11期995-1011,共17页Lei Yang Yi Zhang Li Yang 
supported by grants from the State’s Key Project of Research and Development Plan(Grant No.2021YFE0110600);the National Natural Science Foundation of China(Grant Nos.82072578 and 82350121);the Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(Grant No.ZYCXTD2023013)。
This review examined the critical role of adenosine signaling in modulating the behavior of tumor-associated macrophages(TAMs),a key determinant of the tumor microenvironment(TME).Adenosine is an immunosuppressive met...
关键词：Adenosine signaling CD39 CD73 tumor associated macrophages cancer therapy 
Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective
《World Journal of Hepatology》2024年第10期1208-1212,共5页Nabil Eid Payal Bhatnagar Li-Li Chan Marina Garcia-Macia 
In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic...
关键词：STEATOSIS Liver Xiaoyao San Inflammation ANDROGEN Adenosine 5’-monophosphate-activated protein kinase Phosphatase and tensin homolog Autophagy Lipophagy Alpha smooth muscle actin 
The combination of a microbial and a non-microbial biostimulant increases yield in lettuce(Lactuca sativa) under salt stress conditions by up-regulating cytokinin biosynthesis
《Journal of Integrative Plant Biology》2024年第10期2140-2157,共18页Patricia Benito Marina Celdrán Javier Bellón Vicente Arbona Miguel González-Guzmán Rosa Porcel Lynne Yenush José M.Mulet 
funded by the CDTI program project EXP 00137666/IDI-20210456 awarded to Caldic Ibérica S.L.;the research contract: “Desarrollo de formulados bioestimulantes y biofertilizantes innovadores de origen natural (Calbio) destinados a la agricultura convencional y ecológica. Estudio científico de efectos sinérgicos entre bioactivos microbianos y no microbianos” between Caldic Ibérica S.L. and Universitat Politècnica de València;also funded by the research project CPP2022-009965 “Modelo de evaluación de efectos de bioestimulantes en cultivos con condiciones de stress abiótico: escasez de agua y baja fertilización (MODELCALBIOSTRESS)” funded by MCIN/AEI/ 10.13039/501100011033;the “European Union Next Generation EU/PRTR”;PAID-06-22 “Evaluación del efecto beneficioso de la combinación de diferentes bioestimulantes comerciales (extractos de productos naturales y microbianos) bajo condiciones de estrés salino en plantas de interés agronómico” funded by the Universitat Politècnica de València。
Salinization poses a significant challenge in agriculture, exacerbated by anthropogenic global warming. Biostimulants, derived from living microorganisms or natural extracts, have emerged as valuable tools for convent...
关键词：abscisic acid biostimulants CYTOKININS isopentenyl adenosine LETTUCE salt stress 
A Bioorthogonal Post-modification of N^(6)-Isopentenyl Adenosine i^(6) A RNA in Live Cells
《CCS Chemistry》2024年第9期2241-2253,共13页Li-Jun Xie Hou-Ping Cheng Meng-Yuan Chen Xin Wang Li Liu Bi-Feng Yuan Liang Cheng 
supported by the National Natural Science Foundation of China(grant nos.22022704,21977097,and 22271291);Chinese Academy of Sciences;supported by the Postdoctoral Innovative Talents Support Program(grant no.BX20200337).
Selective methods for modulating RNA epigenetic modifications within living cells and organisms represent attractive techniques for investigating biological functions and medicinal application.In contrast to enzymatic...
关键词：chemical post-modification bioorthogonal reactions RNA modifications N^(6)-isopentenyl adenosine N^(6)-cyanomethyl adenosine 
Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer
《Acta Pharmaceutica Sinica B》2024年第8期3605-3623,共19页Zehui Tan Ning Guo Zhi Cao Shuyu Liu Jiayu Zhang Deyi Ma Jiahao Zhang Wencai Lv Nan Jiang Linghe Zang Lihui Wang Xin Zhai 
supported by the National Natural Science Foundation of China(No.82173685 and No.82073320);Chinese Pharma-ceutical Association-Yi ling Biomedical Innovation Fund(No.CPAYLJ202001,China);Liao Ning Revitalization Talents Program(No.XLYC2002115,China);Key R&D Plan of Liaoning Province in 2020(No.2020020215-JH2/103,China);Development Project of Ministry of Education Innovation Team(No.IRT1073,China);Natural Science Foundation of Shenyang(22-315-6-11,China).
Recent research certified that DOT1L and its mutations represented by R231Q were potential targets for the treatment of lung cancer.Herein,a series of adenosine-containing derivatives were identified with DOT1LR231Q i...
关键词：DOT1L R231Q mutation Lung cancer Adenosine-containing inhibitors EPIGENETICS 
Prolonged asystole following adenosine. Was it necessary?
《Journal of Geriatric Cardiology》2024年第6期686-688,共3页Yuval Avidan Amir Aker Vsevolod Tabachnikov 
A77-year-old woman presented with interchangeable episodes of both fast and slow heart rate.Past history was notable for paroxysmal atrial fibrillation treated with eliquis and tambocor and atrial septal defect closur...
关键词：TACHYCARDIA SEPTAL ATRIAL 
Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders被引量：4
《Neural Regeneration Research》2024年第6期1256-1261,共6页Helen M.Knight Merve DemirbugenÖz Adriana PerezGrovas-Saltijeral 
funded by Notingham University and the Neuroscience Support Group Charity,UK(to HMK);supported by a CONACYT PhD scholarship;MD?was supported by the Postdoctoral Research Fellowship Program of TUBITAK。
The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms.Methylation of N6 adenosine(m^(6)A)and C5 cytosine(m^(5)C)bases occur on mRNA...
关键词：5-methylcytosine methylation Alzheimer's disease cognitive diseases epitranscriptomics intellectual disability Lewy body diseases N6 adenosine RNA modification 
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