Supramolecular G-quadruplex hydrogels:Bridging fabrication to biomedical application  

作　　者：Yuanfeng Li Junjie Chi Pingwei Xu Xing Dong Anh-Tuan Le Keqing Shi Yong Liu Jian Xiao 

机构地区：[1]Translational Medicine Laboratory, The Center of Wound Healing and Regenerative Medicine, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325035, China [2]School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, The Center of Wound Healing and Regenerative Medicine, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang 325035, China [3]Wenzhou Institute, University of Chinese Academy of Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Zhejiang 325001, China [4]Phenikaa University Nano Institute (PHENA), Phenikaa University, Hanoi 12116, Viet Nam

出　　处：《Journal of Materials Science & Technology》2023年第24期238-252,共15页材料科学技术（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Grant Nos.52203184,52003184);the Startup Fund of Wenzhou Institute,University of Chinese Academy of Sciences(Grant No.WIUCASQD2021022).

摘　　要：G-quadruplex hydrogel is a class of self-assembled supramolecular hydrogel formed by guanine derivatives.As a biomimetic hydrogel,G-quadruplex hydrogels demonstrate wide biomedical applications,such as drug delivery,tissue engineering,and biosensing.The advantages of using G-quadruplex hydrogels include adequate biocompatibility and biodegradability,tunable multifunctionality,and cost-effective and large-scalable fabrication process.In this review,we focus on recent progress in the fabrication and characterization of G-quadruplex hydrogels to help readers understand the principles of G-quadruplex hydrogel formation.Meanwhile,the applications of G-quadruplex hydrogels in the biomedical area are discussed,aiming to pave the way for downward clinical or industry translation.The development of G-quadruplex hydrogel is still in its infancy.We hope this review will boost the development of this area and that more applications of G-quadruplex hydrogel will be developed.

关 键 词：GUANOSINE DNA hydrogel Self-assembly Drug delivery Tissue engineering 

分 类 号：TQ427[化学工程] R318[医药卫生—生物医学工程]