FUCOSE

作品数:12被引量:22H指数:3
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相关领域:医药卫生更多>>
相关作者:张国范吴琪李莉更多>>
相关机构:中国科学院中国科学院研究生院中国科学院大学更多>>
相关期刊:《Chinese Medical Journal》《World Journal of Gastroenterology》《Asian Journal of Pharmaceutical Sciences》《海洋与湖沼》更多>>
相关基金:国家重点基础研究发展计划公益性行业(农业)科研专项国家自然科学基金国家高技术研究发展计划更多>>
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Biosynthesis and transfer of 2‑acetamido‑4‑methylamino‑l‑fucose to the core‑lipid A in Bordetella pertussis
《Systems Microbiology and Biomanufacturing》2023年第2期273-286,共14页Liangjia Wang Zhen Wang Shuaiwen Wang Xiaoqing Hu Xiaoyuan Wang 
supported by the National Key Research and Development Program of China(2018YFA0900300);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(CX10295).
The trisaccharide unit in lipopolysaccharide of Bordetella pertussis is important for immune recognition,but how the rare sugar 2-acetamido-4-methylamino-fucose in the trisaccharide unit is synthesized and transferred...
关键词:Bordetella pertussis Escherichia coli LIPOPOLYSACCHARIDE Trisaccharide unit 2-Acetamido-4-methylamino-L-fucose BplL 
Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review被引量:4
《World Journal of Gastroenterology》2019年第23期2947-2960,共14页Pamela A Norton Anand S Mehta 
BACKGROUND Changes in N-linked glycosylation have been observed in the circulation of individuals with hepatocellular carcinoma. In particular, an elevation in the level of core fucosylation has been observed. However...
关键词:Liver cancer N-LINKED GLYCOSYLATION FUCOSE GUANOSINE DIPHOSPHATE FUCOSE Hepatocellular carcinoma 
Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase(FKP)in Bacteroides fragilis被引量:1
《Protein & Cell》2019年第5期365-369,共5页Ying Liu Huifang Hu Jia Wang Qiang Zhou Peng Wu Nieng Yan Hong-Wei Wang Jia-Wei Wu Linfeng Sun 
Dear Editor,L-Fucose(6-deoxy-L-galactose,fucose)is the basic compone nt of a variety of glyca n structures.The fucosylated oligosaccharides participate in a variety of cellular activities,like the cell-cell recognitio...
关键词:CRYO-EM STRUCTURE PYROPHOSPHORYLASE BACTEROIDES fragilis 
Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy被引量:6
《Protein & Cell》2018年第1期47-62,共16页Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd 
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex.type oligosaccharide attached to Asn297 of the Fc is essen- tial...
关键词:chemoenzymatic glycoengineering crysta structure endoglycosidase FUCOSE glycosylation intravenous immunoglobulin sialic acid transglycosylation ultra performance liquid chromatography 
Fucose-appended dendrimer/α-cyclodextrin conjugate as a novel NF-κB decoy carrier to Kupffer cells infulminant hepatitis mice induced by lipopolysaccharide
《Asian Journal of Pharmaceutical Sciences》2016年第1期152-153,共2页Keiichi Motoyama Chiho Akao Ryosuke Mitsuyasu Taishi Higashi Hidetoshi Arima 
Fulminant hepatitis is a serious, life-threatening disorder and is associated with inflammatory cytokines produced by Kupffer cells. However, a number of clinical trials for the treatment of fulminant hepatitis did no...
关键词:Cyclodextrins DENDRIMER FUCOSE FULMINANT hepatitis NF-ΚB DECOY 
Glycoprotein fucosylation is increased in seminal plasma of subfertile men
《Asian Journal of Andrology》2015年第2期274-280,I0010,共8页Beata Olejnik Ewa M Kratz Mariusz Zimmer Mirostawa Ferens-Sieczkowska 
Fucose, the monosaccharide frequent in N- and O-glycans, is a part of Lewis-type antigens that are known to mediate direct sperm binding to the zona pellucida. Such interaction was found to be inhibited in vitro by fu...
关键词:FUCOSE GLYCOSYLATION INFERTILITY seminal plasma 
The re-emergence of the GP73 and fucosylated liver cancer biomarkers
《Engineering Sciences》2014年第4期59-64,共6页Block Timothy 
The study shows that GP73 alone may not be sufficient to achieve the discrimination in every population. This is because many other clinical factors may influence the levels of the biomarker. This review attempts to i...
关键词:hepatocellular carcinoma GP73 alpha fetoprotein FUCOSE biomarkers 
The crystal structure of human GDP-L-fucose synthase被引量:1
《Acta Biochimica et Biophysica Sinica》2013年第9期720-725,共6页Huan Zhou Lihua Sun Jian Li Chunyan Xu Feng yu Yahui Liu Chaoneng Ji Jianhua He 
This work was supported by grants from the Ministry of Science and Technology of China (No. 2011CB911102) and the National Natural Science Foundation of China (No. 31100528).
Human GDP-L-fucose synthase, also known as FX protein, synthesizes GDP-L-fucose from its substrate GDP-4-keto-6- deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent ...
关键词:gdp-e-fucose synthase gdp-L-fucose fx 
Glycosylation of recombinant human thyroid peroxidase ectodomain of insect cell origin has little effect on recognition by serum thyroid peroxidase antibody被引量:7
《Chinese Medical Journal》2013年第15期2907-2911,共5页LILT Ming-ming LI Qing ZHAO Lan-lan GAO Ying HUANG You-yuan LU Gui-zhi GAO Yan-ming GUO Xiao-hui SHI Bing-yin 
Background Thyroid peroxidase (TPO) is an important autoantigen in Hashimoto's thyroiditis (HT), and almost all epitopes are located in TPO ectodomain. The glycosylation of TPO might contribute to breaking self-t...
关键词:thyroid peroxidase baculovirus expression vector system sialic acid GALACTOSE FUCOSE 
Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats被引量:2
《Asian Pacific Journal of Tropical Medicine》2012年第12期939-944,共6页Chinnadurai Veeramani Khalid S Al-Numair Mohammed A Alsaif Govindasamy Chandramohan Nouf S Al-Numair Kodukkur Viswanathan Pugalendi 
provided from the National Nutrition Policy Chair,King Saud University,Riyadh,Saudi Arabia
Objective:To investigate the protective role of Cardiospermum halicacabum(C.halicacabum) leaf extract on glycoprotein metabolism in streptozotocin(STZ)-induced diabetic rats.Methods: Diabetes was induced in male albin...
关键词:STREPTOZOTOCIN Cardiospermum halicacabum leaf extract HEXOSE HEXOSAMINE FUCOSE Sialic acid 
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