supported by the National Key Research and Development Program of China(2018YFA0900300);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(CX10295).
The trisaccharide unit in lipopolysaccharide of Bordetella pertussis is important for immune recognition,but how the rare sugar 2-acetamido-4-methylamino-fucose in the trisaccharide unit is synthesized and transferred...
BACKGROUND Changes in N-linked glycosylation have been observed in the circulation of individuals with hepatocellular carcinoma. In particular, an elevation in the level of core fucosylation has been observed. However...
Dear Editor,L-Fucose(6-deoxy-L-galactose,fucose)is the basic compone nt of a variety of glyca n structures.The fucosylated oligosaccharides participate in a variety of cellular activities,like the cell-cell recognitio...
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex.type oligosaccharide attached to Asn297 of the Fc is essen- tial...
Fulminant hepatitis is a serious, life-threatening disorder and is associated with inflammatory cytokines produced by Kupffer cells. However, a number of clinical trials for the treatment of fulminant hepatitis did no...
Fucose, the monosaccharide frequent in N- and O-glycans, is a part of Lewis-type antigens that are known to mediate direct sperm binding to the zona pellucida. Such interaction was found to be inhibited in vitro by fu...
The study shows that GP73 alone may not be sufficient to achieve the discrimination in every population. This is because many other clinical factors may influence the levels of the biomarker. This review attempts to i...
This work was supported by grants from the Ministry of Science and Technology of China (No. 2011CB911102) and the National Natural Science Foundation of China (No. 31100528).
Human GDP-L-fucose synthase, also known as FX protein, synthesizes GDP-L-fucose from its substrate GDP-4-keto-6- deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent ...
Background Thyroid peroxidase (TPO) is an important autoantigen in Hashimoto's thyroiditis (HT), and almost all epitopes are located in TPO ectodomain. The glycosylation of TPO might contribute to breaking self-t...
provided from the National Nutrition Policy Chair,King Saud University,Riyadh,Saudi Arabia
Objective:To investigate the protective role of Cardiospermum halicacabum(C.halicacabum) leaf extract on glycoprotein metabolism in streptozotocin(STZ)-induced diabetic rats.Methods: Diabetes was induced in male albin...