云南高校图书馆联盟文献共享服务平台- CRYO-EM

CRYO-EM: 作品数：135被引量：210H指数：6; 导出分析报告; 相关领域：生物学更多>>; 相关作者：王兆翔王雪锋陈立泉梁毅刘迎芳更多>>; 相关机构：清华大学中国科学院中国科学院大学天目湖先进储能技术研究院有限公司更多>>; 相关期刊：《Signal Transduction and Targeted Therapy》《Computers, Materials & Continua》《Science China Materials》《Molecular Plant》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金上海市自然科学基金更多>>

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease: 《Neural Regeneration Research》2025年第1期174-180,共7页Yinglong Miao Michael S.Wolfe; supported in part by Award 2121063 from National Science Foundation(to YM);AG66986 from the National Institutes of Health(to MSW).; γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ...; 关键词：Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics NOTCH

Structural insights into somatostatin receptor 5 bound with cyclic peptides: 《Acta Pharmacologica Sinica》2024年第11期2432-2440,共9页Ying-ge Li Xian-yu Meng Xiru Yang Sheng-long Ling Pan Shi Chang-lin Tian Fan Yang; supported by“USTC Research Funds of the Double First-Class Initiative”(YD9990002027 to FY,YD9100002021 to PS);the National Natural Science Foundation of China(22207100 to FY,22277114,31971152 to PS,21825703 to CLT,22307113 to SLL);the National Key Research&Development Project,Ministry of Science and Technology the China(2022YFC3400500 to CLT);Postdoctoral Science Foundation(2022M713054 to FY);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB37000000 to CLT);Anhui Provincial Natural Science Foundation(2108085J16 to PS);And the National Key R&D Program of China(2021YFA1200104 to SLL);supported by“the Fundamental Research Funds for the Central Universities”.; Somatostatin receptor 5(SSTR5)is highly expressed in ACTH-secreting pituitary adenomas and is an important drug target for the treatment of Cushing’s disease.Two cyclic SST analog peptides(pasireotide and octreotide)...; 关键词：G protein-coupled receptors Somatostatin receptor 5 PASIREOTIDE OCTREOTIDE CRYO-EM

Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus: 《Acta Pharmaceutica Sinica B》2024年第11期4899-4913,共15页Meng Wang Hekai Chen Tuan Zhang Zhikuan Zhang Xuwen Xiang Meng Gao Yilan Guo Shuangshuang Jiang Kejun Yin Mintao Chen Jian Huang Xincheng Zhong Umeharu Ohto Jing Li Toshiyuki Shimizu Hang Yin; National Natural Science Foundation of China(Grant No.22137004 and 82430109);Beijing Outstanding Young Scientist Program Grant No.BJJWZYJH01201910003013(China);Natural Science Foundation of Beijing,China(Grant No.IS23107).; Endosomal TLRs(TLR3/7/8/9)are highly analogous innate immunity sensors for various viral or bacterial RNA/DNA molecular patterns.Among them,TLR7,in particular,has been suggested to be a target for various inflammatory...; 关键词：TLR7 Small-moleculeinhibitor Atomisticresolutioncryo-EM structure Resting state Systemiclupus erythematosus MRL

Architecture of the ATP-driven motor for protein import into chloroplasts: 《Molecular Plant》2024年第11期1702-1718,共17页Ning Wang Jiale Xing Xiaodong Su Junting Pan Hui Chen Lifang Shi Long Si Wenqiang Yang Mei Li; funded by the Strategic Priority Research Program of CAS(XDB37020101);the National Key R&D Program of China(2021YFA0910800);the National Natural Science Foundation of China(31930064);the Youth Innovation Promotion Association,Chinese Academy of Sciences(Y2022038);the Regional Joint Key Projects of the National Foundation of China(U22A20445);the Natural Science Foundation of Shandong Province(ZR2023ZD30).; Thousands of nuclear-encoded proteins are transported into chloroplasts through the TOC–TIC translocon that spans the chloroplast envelope membranes.A motor complex pulls the translocated proteins out of the TOC–TIC...; 关键词：chloroplast protein translocation cryo-EM structure Orf2971–FtsHi ATP-driven motor CHLAMYDOMONAS

Cryo-EM vs.Disease X: 《四川生理科学杂志》2024年第10期2349-2349,共1页Fasséli Coulibaly; In this issue of Cell,Penzes et al.describe the use of cryo-EM to identify the cause of a mysterious disease affecting farmed superworms across the US.The study illustrates the power of ex vivo cryo-EM,which uses ampl...; 关键词：MECHANISM PACKAGING VIVO

Structural insights into the unusual core photocomplex from a triply extremophilic purple bacterium,Halorhodospira halochloris: 《Journal of Integrative Plant Biology》2024年第10期2262-2272,共11页Chen-Hui Qi Guang-Lei Wang Fang-Fang Wang Jie Wang Xiang-Ping Wang Mei-Juan Zou Fei Ma Michael T.Madigan Yukihiro Kimura Zheng-Yu Wang-Otomo Long-Jiang Yu; supported in part by the National Key R&D Program of China(No.2022YFC3401800);National Natural Science Foundation of China(32070264);Shandong Provincial Natural Science Foundation(ZR2019ZD48);the Strategic Priority Research Program of CAS(XDA26050402);the Science&Technology Specific Project in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta(2022SZX12);the Innovation Center for Academicians of Hainan Province;the Specific Research Fund of the Innovation Center for Academicians of Hainan Province(No.YSPTZX202309);supported in part by NASA Cooperative Agreement 80NSSC21M0355。; Halorhodospira(Hlr.)halochloris is a triply extremophilic phototrophic purple sulfur bacterium,as it is thermophilic,alkaliphilic,and extremely halophilic.The light-harvesting-reaction center(LH1–RC)core complex of t...; 关键词：CRYO-EM LH1-RC single carotenoid three bacteriochlorophyll b molecules triply extremophilic purple bacterium unusual Qy red shift

Inhibition mechanisms of CRISPR-Cas9 by AcrⅡA25.1 and AcrⅡA32: 《Science China(Life Sciences)》2024年第9期1781-1791,共11页Jianlin Zheng Yuwei Zhu Tengjin Huang Wenbo Gao Jiale He Zhiwei Huang; supported by the National Key Research and Development Program of China(2023YFF1000200);the National Natural Science Foundation of China(U21A20276);the Tencent Foundation through the XPLORER PRIZE and the New Cornerstone Science Foundation to Z.H.,Heilongjiang Touyan Team(HITTY-20190034 to Z.H.);Natural Science Foundation of Heilongjiang Province of China(YQ2023C032 to Y.Z.)。; In the ongoing arms race between bacteria and bacteriophages,bacteriophages have evolved anti-CRISPR proteins to counteract bacterial CRISPR-Cas systems.Recently,AcrⅡA25.1 and AcrⅡA32 have been found to effectively ...; 关键词：anti-CRISPR CRYO-EM Spy Cas9 AcrⅡA25.1 AcrⅡA32 inhibiton

The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses: 《Virologica Sinica》2024年第4期609-618,共10页Junsen Chen Junqing Sun Zepeng Xu Linjie Li Xinrui Kang Chunliang Luo Qi Wang Xueyang Guo Yan Li Kefang Liu Ying Wu; supported by the National Key R&D Program of China(2022YFC2303401,2021YFA1300803);National Natural Science Foundation of China(32122008);supported by Young Elite Scientists Sponsorship Program by CAST(2021QNRC001);fellowships from the China Postdoctoral Science Foundation(2022T150688);the Postdoctoral Science Foundation of China(2021M700161).; Foxes are susceptible to SARS-CoV-2 in laboratory settings,and there have also been reports of natural infections of both SARS-CoV and SARS-CoV-2 in foxes.In this study,we assessed the binding capacities of fox ACE2 t...; 关键词：Sarbecoviruses SARS-COV SARS-CoV-2 Fox ACE2 Omicron Cryo-EM structure

Subtraction of liposome signals in cryo-EM structural determination of protein-liposome complexes: 《Chinese Physics B》2024年第8期569-577,共9页李首卿李明王玉梅李雪明; Project supported by the National Natural Science Foundation of China (Grant Nos.32241023 and 92254306);the Fund from the Tsinghua–Peking Joint Center for Life Sciences;Beijing Frontier Research Center for Biological Structure。; Reconstituting membrane proteins in liposomes and determining their structure is a common method for determining membrane protein structures using single-particle cryo-electron microscopy(cryo-EM).However,the strong s...; 关键词：CRYO-EM protein–liposome complexes liposome signal subtraction 2D classification averaging

Cryo-EM combined with image deconvolution to determine ZIF-8 crystal structure: 《Chinese Physics B》2024年第7期44-49,共6页吴抗杨柏松薛文华孙大鹏葛炳辉王玉梅; Project supported by the National Natural Science Foundation of China(Grant Nos.12074409 and 12374021)。; Metal–organic frameworks(MOFs) are crystalline porous materials with tunable properties, exhibiting great potential in gas adsorption, separation and catalysis.[1,2]It is challenging to visualize MOFs with transmissi...; 关键词：cryo-electron microscopy(cryo-EM) ZIF-8 image deconvolution crystal structure determination

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