ANTI-CANCER

作品数：245被引量：664H指数：12
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相关机构：北京大学福建省亚热带植物研究所福建农林大学内蒙古医科大学附属医院更多>>
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Predicting anti-cancer drug sensitivity through WRE-XGBoost algorithm with weighted feature selection
《Genes & Diseases》2025年第2期15-17,共3页Yiyao Jiang Ming Chen Zhongmin Xiong Yufang Qin 
supported in part by the Shanghai Science and Technology Innovation Action Planning (No.20dz1203800 to M.C.);the Research and Development Planning in Key Areas of Guangdong Province,China (No.2021 B0202070001 to M.C.);the National Natural Sci-ence Foundation of China (No.61702325 to Y.Q.).
Accurate prediction of drug susceptibility is one of themost important steps in personalized medicine.Applications of machine learning to pharmacogenomic data for sensitivity prediction can help study the mechanism of...
关键词：STEPS SUSCEPTIBILITY ALGORITHM 
Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism
《Cancer Biology & Medicine》2025年第2期144-165,共22页Lili Yan Yanfen Liu Yufei Huang Xiaoyu Sun Haiyang Jiang Jie Gu Jing Xia Xueni Sun Xinbing Sui 
supported by the National Natural Science Foundation of China(82104207);Natural Science Foundation of Zhejiang Province(LQ22H280001)。
Objective:Erianin has potential anticancer activities,especially against lung cancer.The specific mechanisms underlying the anticancer effects,including the molecular targets and signaling pathways in lung cancer,rema...
关键词：ERIANIN anti-cancer property lung cancer MTOR pyrimidine metabolism 
Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition
《Nano Research》2025年第1期545-558,共14页Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting Fu Jing Liu Yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin Yin 
funded by Young Elite Scientists Sponsorship Program by CACM(No.2021-QNRC2-A03);the Beijing Natural Science Foundation(No.7202121);the National Natural Science Foundation of China(No.81703715).
Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggrava...
关键词：QUERCETIN Fe-metal organic frameworks(MOFs) PHOTOTHERAPY ANTI-CANCER heat shock proteins inhibition 
Green synthesis of zinc oxide nanoparticles:Eco-friendly advancements for biomedical marvels
《Resources Chemicals and Materials》2024年第4期294-316,共23页Nandhini J Karthikeyan E Rajeshkumar S 
This article explores an in-depth analysis of eco-friendly green synthesis methods to manufacture zinc oxide nanoparticles(ZnO NPs).Although chemical and/or physical approaches may initially provide better results;in ...
关键词：Zinc oxide nanoparticles Green synthesis ANTIMICROBIAL Drug delivery Anti-cancer and biomedical applications 
Harnessing the power of Calculus bovis:Anti-cancer properties and Wnt pathway modulation in hepatocellular carcinoma
《World Journal of Gastroenterology》2024年第41期4496-4502,共7页Himanshi Goyal Sachin Parwani Kaneez Fatima Jyotdeep Kaur 
In this manuscript,we comment on the article,which explores the anti-cancer effects of Calculus bovis(CB)in tumor biology.We highlight its potential,particularly in hepatocellular carcinoma(HCC),where it inhibits the ...
关键词：Calculus bovis Liver cancer Tumor-associated macrophages M2 polarization Wnt signaling pathway 
FDA approved fluorine-containing drugs in 2023
《Chinese Chemical Letters》2024年第11期111-122,共12页Qian Wang Yeping Bian Gagan Dhawan Wei Zhang Alexander E.Sorochinsky Ata Makarem Vadim A.Soloshonok Jianlin Han 
support from the National Natural Science Foundation of China (No.21761132021);the Qing-Lan Project of Jiangsu Province (for Han) and IKERBASQUE,Basque Foundation for Science (for Soloshonok)。
This review profiles twelve fluorine-containing drugs approved by the US Food and Drug Administration(FDA) for the clinic in 2023.These small molecule drugs represent such therapeutic areas as cancer,neuromuscular dis...
关键词：Fluorine-containing compounds Blockbuster drugs Pharmaceuticals ANTI-CANCER Drug design and development Asymmetric synthesis 
Plant-microbial interactions inspired the discovery of novel sesquiterpenoid dimeric skeletons of hidden natural products from Hibiscus tiliaceus
《Chinese Chemical Letters》2024年第10期286-290,共5页Deli Chen Jiawen Li Xudong Xu Zhaocui Sun Yun Yang Minghui Xu Hanqiao Liang Junshan Yang Hui Meng Guoxu Ma Jianhe Wei 
financially supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(Nos.2021-I2M-1-032,2021I2M-1-071);the Key Research Project of Hainan Province(No.ZDYF2020111);Project supported by the Research Fund for Development Program of Beijing City University(No.KYF202003)。
Hidden natural products are representative of defensive strategies produced in vivo in diseased plants,a process that is induced by the plant immune system.The first transcriptome library of uninfected and pathogen in...
关键词：Cadinane-derived sesquiterpenoid ANTI-CANCER PI3K Plant-microbial interactions 
Hydrophobic tagging-induced degradation of NAMPT in leukemia cells
《Chinese Chemical Letters》2024年第9期214-218,共5页Menglu Guo Ying-Qi Song Junfei Cheng Guoqiang Dong Xun Sun Chunquan Sheng 
supported by the National Key Research and Development Program of China(No.2022YFC3401500 to C.S.);the National Natural Science Foundation of China(No.82030105 to C.S.);and Shanghai Rising-Star Program(No.20QA1411700 to G.D.)。
Nicotinamide phosphoribosyl transferase(NAMPT)is considered as a promising target for cancer therapy to its crucial role in cancer metabolism.Despite the therapeutic potential of NAMPT enzymatic inhibitors,their effec...
关键词：NAMPT Hydrophobic tagging LEUKEMIA Degradation ANTI-CANCER 
Exploring the molecular mechanism of Solanum nigrum L in breast cancer treatment through network pharmacology and molecular docking validation
《Pharmacology Discovery》2024年第3期1-16,共16页Mei Zheng Ju-Min Xie 
supported by Local special projects in major health of Hubei Provincial Science and Technology Department(2022BCE054);Key scientific research projects of Hubei polytechnic University(23xjz08A);Hubei polytechnic University Huangshi Daye Lake high-tech Zone University Science Park joint open fund project(23xjz04AK).
In 2020,breast cancer emerged as the leading type of cancer worldwide,surpassing lung cancer in the number of new cases.The high cost and frequent failure of current treatments due to drug resistance and other challen...
关键词：ANTI-CANCER molecular docking network pharmacology Solanum Nigrum L 
Anti-Cancer, Anti-Oxidant and Anti-Inflammatory Effects of Herbacetin and Its Molecular Mechanisms
《Asian Agricultural Research》2024年第8期29-31,37,共4页Jiaren LIU Wenshuang HOU Chenghao JIN 
Supported by Talent Training Project of Central Support for the Reform and Development Fund of Local Colleges and Universities(2020GSP16);Heilongjiang Provincial Key R&D Plan Guidance Project(GZ20220039);Daqing Guiding Science and Technology Project(zdy-2024-91).
Rhodiola rosea,a perennial herb of the genus Rhodiola in the Crassulaceae family,is commonly used to treat depression,fatigue,cancer and cardiovascular diseases.Herbacetin is a natural flavonol compound extracted from...
关键词：Herbacetin MOLECULAR MECHANISMS ANTI-CANCER ANTI-OXIDANT ANTI-INFLAMMATORY 
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