supported by the Polish National Science Center research grants:OPUS 16[grant number:2018/31/B/NZ9/00781];OPUS 20[grant number:2020/39/B/NZ9/01061]and SONATA 16[grant number:2020/39/D/NZ9/01009]。
Background The pituitary belongs to the most important endocrine glands involved in regulating reproductive functions.The proper functioning of this gland ensures the undisturbed course of the oestrous cycle and affec...
supported by the National Key Research and Development Program of China(No.2022YFC3401500 to C.S.);the National Natural Science Foundation of China(No.82030105 to C.S.);and Shanghai Rising-Star Program(No.20QA1411700 to G.D.)。
Nicotinamide phosphoribosyl transferase(NAMPT)is considered as a promising target for cancer therapy to its crucial role in cancer metabolism.Despite the therapeutic potential of NAMPT enzymatic inhibitors,their effec...
funded by the National Natural Science Grant of China(No.82072225,82272246);High-level Hospital Construction Project of Guangdong Provincial People’s Hospital(No.DFJHBF202104,No.DFJH201918);Science and Technology Program of Guangzhou,China(No.202206010044);Guangdong Basic and Applied Basic Research Foundation(2021B1515120062).
Abdominal Aortic Aneurysm(AAA)is a life-threatening vascular disease characterized by the weakening and ballooning of the abdominal aorta,which has no effective therapeutic approaches due to unclear molecular mechanis...
This work was supported by the National Key Research and Development Programme of China(No.YFA1303800);the Fundamental Research Funds for the Central Universities(No.2632023TD10);the National Natural Science Foundation of China(No.81930109).
NAD(P)H:quinone oxidoreductase 1(NQO1)is a flavin protease highly expressed in various cancer cells.NQO1 catalyzes a futile redox cycle in substrates,leading to substantial reactive oxygen species(ROS)production.This ...