ERIANIN

作品数：7被引量：112H指数：4
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相关领域：医药卫生更多>>
相关作者：马国祥王晶苏鹏唐亚雄王峥涛更多>>
相关机构：中国药科大学中国科学院成都生物研究所南京中医药大学北卡罗来纳州立大学更多>>
相关期刊：《Cancer Biology & Medicine》《Acta Pharmacologica Sinica》《Signal Transduction and Targeted Therapy》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金更多>>
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Erianin inhibits the proliferation of lung cancer cells by suppressing mTOR activation and disrupting pyrimidine metabolism
《Cancer Biology & Medicine》2025年第2期144-165,共22页Lili Yan Yanfen Liu Yufei Huang Xiaoyu Sun Haiyang Jiang Jie Gu Jing Xia Xueni Sun Xinbing Sui 
supported by the National Natural Science Foundation of China(82104207);Natural Science Foundation of Zhejiang Province(LQ22H280001)。
Objective:Erianin has potential anticancer activities,especially against lung cancer.The specific mechanisms underlying the anticancer effects,including the molecular targets and signaling pathways in lung cancer,rema...
关键词：ERIANIN anti-cancer property lung cancer MTOR pyrimidine metabolism 
Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2被引量：4
《Signal Transduction and Targeted Therapy》2023年第4期1874-1888,共15页Penglei Wang Xuechao Jia Bingbing Lu Han Huang Jialin Liu Xuejiao Liu Qiong Wu Yamei Hu Pan Li Huifang Wei Tingting Liu Dengyun Zhao Lingwei Zhang Xueli Tian Yanan Jiang Yan Qiao Wenna Nie Xinli Ma Ruihua Bai Cong Peng Zigang Dong Kangdong Liu 
the National Natural Science Foundations of China(No.81872335);The Central Plains Science and Technology Innovation Leading Talents(No.224200510015);Program for Science&Technology Innovation Talents in Universities of Henan(No.20HASTIT048);the Cultivation Foundation of Zhengzhou University(No.JC202035022)。
Constitutive activation of RAS-RAF-MEK-ERK signaling pathway(MAPK pathway)frequently occurs in many cancers harboring RAS or RAF oncogenic mutations.Because of the paradoxical activation induced by a single use of BRA...
关键词：MEK1/2 BRAF ACTIVATION 
Erianin inhibits oral cancer cell growth,migration,and invasion via the Nrf2/HO-1/GPX4 pathway被引量：2
《Asian Pacific Journal of Tropical Biomedicine》2022年第10期437-445,共9页Xiu-Yun Tian Rui Han Qing-Yang Huang Mei-Yun Zhou Bin Luo Xin-Ru Chen Jin-Cheng Xu 
Objective:To evaluate the effect of erianin on the viability,migration,and invasion of KB cells and elucidate its underlying mechanisms.Methods:Cell Counting Kit-8,colony formation,wound healing,and Transwell assays w...
关键词：ERIANIN Ferroptosis Oral cancer Reactive oxygen species Therapy Nrf2/HO-1/GPX4 
Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis被引量：62
《Signal Transduction and Targeted Therapy》2020年第1期1882-1892,共11页Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui 
supported by grants from the National Natural Science Foundation of China(grant Nos.81672932,81730108,81874380,and 81973635);the Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars(grant No.LR18H160001);the Zhejiang Province Science and Technology Project of TCM(grant No.2019ZZ016);the Open Project Program of the Jiangsu Key Laboratory of Pharmacology and Safety Evaluation of Chinese Materia Medica(No.JKLPSE201807).
Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells m...
关键词：PEROXIDATION lung drugs 
Erianin induces apoptosis in human leukemia HL-60 cells被引量：6
《Acta Pharmacologica Sinica》2001年第11期1018-1022,共5页李运曼 王海燕 刘国卿 
AIM: To investigate the effect of erianin on human HL-60 cell line and explore its mechanism of apoptosis in vitro. METHODS: Inhibition of proliferation was measured with colorimetric MTT assay. The morphologic change...
关键词：ERIANIN LEUKEMIA HL-60 cells APOPTOSIS DNA fragmentation cell cycle bcl-2 genes 
The Activity of Erianin and Chrysotoxine from Dendrobium chrysotoxum to Reverse Multidrug Resistance in B16/h MDR-1 Cells被引量：9
《Journal of Chinese Pharmaceutical Sciences》1998年第3期30-34,共5页马国祥 
The ability of two dihydrostilbene derivatives erianin and chrysotoxine from Dendrobium chrysotoxum to reverse multidrug resistant (MDR) cells was investigated using murine B16 melanoma cells transfected with the huma...
关键词：Dihydrostilbene ERIANIN Chrysotoxine Multidrug resistance (MDR) P  glycoprotein (P  gp) 
反相高效液相色谱法测定18种石斛类生药中chrysotoxene，erianin及chrysotoxine的含量被引量：38
《中国药科大学学报》1994年第2期103-105,共3页马国祥 徐国钧 徐珞珊 王峥涛 
国家自然科学基金
采用反相ＨＰＬＣ法测定１８种石斛中ｃｈｒｙｓｏｔｏｘｅｎｅ，ｅｒｉａｎｉｎ及ｃｈｒｙｓｏｔｏｘｉｎｅ的含量。固定相ＯＤＳ－Ｃ＿（１８）２４ｃｍ×４．６ｍｍ，流动相甲醇－乙腈－水（６０：６０：１６５），检测波长２３７ｎ...
关键词：石斛 chrysotoxene ERIANIN HPLC 
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