Harnessing the power of Calculus bovis:Anti-cancer properties and Wnt pathway modulation in hepatocellular carcinoma  

作　　者：Himanshi Goyal Sachin Parwani Kaneez Fatima Jyotdeep Kaur 

机构地区：[1]Department of Biochemistry,Post Graduate Institute of Medical Education and Research,Chandigarh 160012,India

出　　处：《World Journal of Gastroenterology》2024年第41期4496-4502,共7页世界胃肠病学杂志（英文）

摘　　要：In this manuscript,we comment on the article,which explores the anti-cancer effects of Calculus bovis(CB)in tumor biology.We highlight its potential,particularly in hepatocellular carcinoma(HCC),where it inhibits the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways and induces apoptosis.CB contains compounds such as oleanolic acid and ursolic acid that target interleukin-6,mitogen-activated protein kinase 8,vascular endothelial growth factor,and caspase-3,offering anti-inflammatory and hepatoprotective benefits.The manuscript also discusses CB sativus(CBS),an artificial substitute,which has shown efficacy in reducing hepatic inflammation and oxidative stress in animal models.We emphasize the need for further research on the effects of CBS on the gut-liver axis and gut microbiota,and on targeting Wnt signaling and M2 tumor-associated macrophage as potential therapeutic strategies against HCC.

关 键 词：Calculus bovis Liver cancer Tumor-associated macrophages M2 polarization Wnt signaling pathway 

分 类 号：R735.7[医药卫生—肿瘤]