Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition  

作　　者：Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting Fu Jing Liu Yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin Yin 

机构地区：[1]Beijing University of Chinese Medicine,Fangshan District,Beijing 102488,China

出　　处：《Nano Research》2025年第1期545-558,共14页纳米研究（英文版）

基　　金：funded by Young Elite Scientists Sponsorship Program by CACM(No.2021-QNRC2-A03);the Beijing Natural Science Foundation(No.7202121);the National Natural Science Foundation of China(No.81703715).

摘　　要：Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this problem.Herein, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关 键 词：QUERCETIN Fe-metal organic frameworks(MOFs) PHOTOTHERAPY ANTI-CANCER heat shock proteins inhibition 

分 类 号：R737.9[医药卫生—肿瘤]