FDA approved fluorine-containing drugs in 2023  

作　　者：Qian Wang Yeping Bian Gagan Dhawan Wei Zhang Alexander E.Sorochinsky Ata Makarem Vadim A.Soloshonok Jianlin Han 

机构地区：[1]Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China [2]Jiangsu Province Geriatric Hospital,Nanjing 210024,China [3]School of Allied Medical Sciences,Delhi Skill and Entrepreneurship University,and Department of Biomedical Science,Acharya Narendra Dev College,University of Delhi,New Delhi 110019,India [4]Department of Chemistry,University of Massachusetts Boston,Boston,MA 02125,United States [5]V.P.Kukhar Institute of Bioorganic Chemistry and Petrochemistry,The National Academy of Sciences of Ukraine,Kyiv 02094,Ukraine [6]Department of Chemistry,University of Hamburg,Martin-Luther-King-Platz 6,Hamburg 20146,Germany [7]Department of Organic Chemistry I,Faculty of Chemistry,University of the Basque Country UPV/EHU,Paseo Manuel Lardizábal 3,San Sebastián 20018,Spain [8]IKERBASQUE,Basque Foundation for Science,María Díaz de Haro 3,Plaza Bizkaia,Bilbao 48013,Spain

出　　处：《Chinese Chemical Letters》2024年第11期111-122,共12页中国化学快报（英文版）

基　　金：support from the National Natural Science Foundation of China (No.21761132021);the Qing-Lan Project of Jiangsu Province (for Han) and IKERBASQUE,Basque Foundation for Science (for Soloshonok)。

摘　　要：This review profiles twelve fluorine-containing drugs approved by the US Food and Drug Administration(FDA) for the clinic in 2023.These small molecule drugs represent such therapeutic areas as cancer,neuromuscular disorder,immunodeficiency,virology,and infectious diseases.Medicinal chemistry discovery,biological activity,and synthetic routes have been discussed for each drug.Also,new trends in structural positioning,functionality,and degree of fluorination are discussed.Besides fluorination,the importance of amino acid residues and chirality in the design of new pharmaceuticals is highlighted.

关 键 词：Fluorine-containing compounds Blockbuster drugs Pharmaceuticals ANTI-CANCER Drug design and development Asymmetric synthesis 

分 类 号：TQ460.1[化学工程—制药化工]