Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents  

作　　者：Weiyi Chu Chia Wei Phan Seng Joe Lim Abdul Salam Babji 

机构地区：[1]Department of Pharmaceutical Life Sciences,Faculty of Pharmacy,Universiti Malaya,Kuala Lumpur 50603,Malaysia [2]Clinical Investigation Centre,University Malaya Medical Centre,Lembah Pantai Kuala Lumpur 59100,Malaysia [3]Mushroom Research Centre,Universiti Malaya,Kuala Lumpur 50603,Malaysia [4]Department of Food Sciences,Faculty of Science and Technology,Universiti Kebangsaan Malaysia,UKM Bangi,Selangor 43600,Malaysia [5]Innovation Centre for Confectionery Technology(MANIS),Faculty of Science and Technology,Universiti Kebangsaan Malaysia,UKM Bangi,Selangor 43600,Malaysia

出　　处：《Food Science and Human Wellness》2023年第4期1008-1019,共12页食品科学与人类健康（英文）

基　　金：supported by the Research Excellence Consortium(KKP/2020/UKM-UKM/5/1)provided by Ministry of Higher Education,Malaysia;supported by the Fundamental Research Grant Scheme(FRGS),Project No.FP016-2019A,Reference Code:FRGS/1/2019/SKK09/UM/02/2.

摘　　要：Neurodegenerative diseases are often associated with the accumulation of oxidative stress and neuroinflammation.Edible bird’s nest(EBN)is a glycoprotein(sialylated mucin glycopeptides)found to be beneficial against neurodegenerative diseases.Antioxidative,anti-inflammatory,and anti-apoptotic properties of EBN in preserving neuronal cells were widely researched using in vitro and in vivo models.Functional effects of EBN are often linked to its great number of antioxidants and anti-inflammatory glycopeptides.Bioactive compounds in EBN,especially sialic acid,add value to neurotrophic potential of EBN and contribute to neuronal repair and protection.Various studies reporting the neuroprotective effects of EBN,their molecular mechanisms,and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of EBN.

关 键 词：Antioxidant Composition Edible bird nest Neurodegenerative disease NEUROPROTECTION Sialylated mucin glycopeptide 

分 类 号：TS201.4[轻工技术与工程—食品科学]