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GLUCAGON: 作品数：75被引量：119H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：韩京王爽丁学屏蔡淦陆灏更多>>; 相关机构：江苏师范大学广西医科大学宁波大学上海中医药大学附属曙光医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划湖南省教育厅科研基金国家科技支撑计划更多>>

Glucagon-like peptide-1 and impaired counterregulatory responses to hypoglycemia in type 1 diabetes: 《World Journal of Diabetes》2025年第2期297-304,共8页Gabriel Reis Rocha Fabrício Freire de Melo; Industrial Technological Initiation Scholarship of National Council for Scientific and Technological Development,CNPq,No.0932204294929829;CNPq Research Productivity Fellow,No.4357511882624145.; This letter comments on a study by Jin et al,published recently in the World Journal of Diabetes.Hypoglycemia is a significant complication of diabetes,with primary defense mechanisms involving the stimulation of gluc...; 关键词：Glucagon-like peptide 1 Type 1 diabetes mellitus Counterregulatory hypoglycemic dysfunction Hypoglycemia unawareness GLUCAGON Sympathoadrenal system

Intestinal glucagon-like peptide-1:A new regulator of impaired counterregulatory responses to hypoglycemia in type 1 diabetes mellitus: 《World Journal of Diabetes》2025年第1期217-221,共5页Le-Rong Liu Yuan-Yuan Luo Pei-Zhu Su Cong Zhang Zhao-Tao Li; Supported by the National Natural Science Foundation of China,No.82400966;Guangdong Basic and Applied Basic Research Foundation,No.2021A1515111025;Science and Technology Projects in Guangzhou,No.2024A04J5170.; In this article,we review the study by Jin et al,which examined the role of intestinal glucagon-like peptide-1(GLP-1)in counterregulatory responses to hypoglycemia in patients with type 1 diabetes mellitus(T1DM).With ...; 关键词：Glucagon-like peptide-1 Impaired counterregulation Type 1 diabetes mellitus Sympathetic-adrenal reflex GLUCAGON

Role of intestinal glucagon-like peptide-1 in impaired counterregulatory responses to hypoglycemia: 《World Journal of Diabetes》2024年第12期2394-2398,共5页Manjunath Havalappa Dodamani Juniali Hatwal Akash Batta; Patients with type 1 diabetes mellitus(T1DM)experience multiple episodes of hypoglycemia,resulting in dysfunctional counter-regulatory responses with time.The recent experimental study by Jin et al explored the role o...; 关键词：Glucagon-like peptide-1 Type-1 diabetes mellitus HYPOGLYCEMIA Counter-regulatory responses CATECHOLAMINES Adrenergic response GLUCAGON

Glucagon-like peptide-1 agonists:Role of the gut in hypoglycemia unawareness,and the rationale in type 1 diabetes: 《World Journal of Diabetes》2024年第11期2167-2172,共6页Hyder O Mirghani; Type 1 diabetes is increasing and the majority of patients have poor glycemic control.Although advanced technology and nanoparticle use have greatly enhanced insulin delivery and glucose monitoring,weight gain and hyp...; 关键词：Glucagon-like peptide-1 receptor agonists Glucagon response Hypoglycemia unawareness GUT Type 1 diabetes

Role of incretins and glucagon receptor agonists in metabolic dysfunction-associated steatotic liver disease:Opportunities and challenges: 《World Journal of Hepatology》2024年第5期731-750,共20页Chencheng Xie Naim Alkhouri Mohamed A Elfeki; Metabolic dysfunction-associated steatotic liver disease(MASLD)has become the most common chronic liver disease worldwide,paralleling the rising pandemic of obesity and type 2 diabetes.Due to the growing global health...; 关键词：Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Glucagon-like peptide-1 Glucose-dependent inulinotropic polypeptide GLUCAGON INCRETIN Receptor agonist

Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis: 《Acta Pharmaceutica Sinica B》2024年第3期1283-1301,共19页Qian Zhao Jiale Dong Han Liu Hui Chen Huan Yu Shuyin Ye Shuangjin Yu Yu Li Longhui Qiu Nazi Song Hongjiao Xu Qi Liu Zhiteng Luo Yuyi Li Rui Wang Guodong Chen Xianxing Jiang; financial support from the National Natural Science Foundation of China(No.82273761 and No.81871257);the Medical Innovation and Development Project of Lanzhou University(lzuyxcx-2022-156,China);the Undergraduate Teaching Quality Engineering Project of Sun Yat-sen University[2021]93;the Guangdong Provincial Key Laboratory of Construction Foundation(2023B1212060022,China)。; The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKD)remains unclear.Herein we found that GLP-1R and GCGR expression levels were lower in the kidn...; 关键词：GLP-1 receptor Glucagon receptor Chronic kidney disease Diabetic nephropathy Kidney fibrosis Dual-agonism

25-Hydroxyvitamin D Is Associated with Islet Homeostasis in Type-2 Diabetic Patients with Abdominal Obesity: 《Current Medical Science》2023年第5期919-926,共8页Qing LI Wen ZHANG Bing HAN Yu-ying WANG Heng WAN Min ZHANG Ning-jian WANG Ying-li LU; supported by the National Natural Science Foundation of China(No.82120108008,No.91857117);the Project of Biobank(No.YBKA201909)from Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine;a grant from Shanghai Jiaotong University School of Medicine(No.19XJ11007).; Objective Isletαcells input is essential for insulin secretion fromβcells.The present study aims to investigate the association between 25-hydroxyvitamin D[25(OH)D]and islet function homeostasis in type-2 diabetes(T...; 关键词：25-hydroxyvitamin D GLUCAGON C-PEPTIDE isletαcells isletβcells type-2 diabetes

Xenopus GLP-1-based glycopeptides as dual glucagon-like peptide 1 receptor/glucagon receptor agonists with improved in vivo stability for treating diabetes and obesity被引量：1: 《Chinese Journal of Natural Medicines》2022年第11期863-872,共10页LI Qiang YANG Qimeng HAN Jing LIU Xiaohan FU Junjie YIN Jian; supported by the Fundamental Research Funds for the Central Universities(No.JUSRP51712B);the Natural Science Foundation of Xuzhou(No.KC19154);the Open Project Program of Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,Ministry of Education,Guangxi Medical University(No.GKE-KF202006)。; Peptide dual agonists toward both glucagon-like peptide 1 receptor(GLP-1R)and glucagon receptor(GCGR)are emerging as novel therapeutics for the treatment of type 2 diabetes mellitus(T2DM)patients with obesity.Our prev...; 关键词：Glucagon-like peptide-1 GLUCAGON DIABETES OBESITY O-GLCNACYLATION

Regulation ofα-cell glucagon secretion:The role of second messengers: 《Chronic Diseases and Translational Medicine》2022年第1期7-18,共12页Samuel Acreman Quan Zhang; EFSD European Research Programme on New Targets for Type 2 Diabetes(Grant/Award Number:96406);Diabetes UK RD Lawrence Fellowship(Grant/Award Number:14/0005128)。; Glucagon is a potent glucose-elevating hormone that is secreted by pancreaticα-cells.While well-controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypogly...; 关键词：GLUCAGON pancreatic islet second messenger

Hypoglycemia in diabetes:An update on pathophysiology,treatment,and prevention被引量：10: 《World Journal of Diabetes》2021年第12期2036-2049,共14页Afif Nakhleh Naim Shehadeh; Hypoglycemia is a common complication in patients with diabetes,mainly in those treated with insulin,sulfonylurea,or glinide.Impairments in counterregulatory responses and hypoglycemia unawareness constitute the main ...; 关键词：HYPOGLYCEMIA Diabetes mellitus INSULIN GLUCAGON GLUCOSE Continuous glucose monitoring

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