Intestinal glucagon-like peptide-1:A new regulator of impaired counterregulatory responses to hypoglycemia in type 1 diabetes mellitus  

作　　者：Le-Rong Liu Yuan-Yuan Luo Pei-Zhu Su Cong Zhang Zhao-Tao Li 

机构地区：[1]Department of Endocrinology and Metabolism,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong Province,China [2]Department of Endocrinology,Chongqing University Three Gorges Hospital,Chongqing 404100,China [3]Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases,Chongqing University Three Gorges Hospital,Chongqing 404100,China [4]Department of Endocrinology,The Second Affiliated Hospital,Chongqing Medical University,Chongqing 400013,China [5]Department of Gastroenterology,The First People's Hospital of Foshan,Foshan 528000,Guangdong Province,China

出　　处：《World Journal of Diabetes》2025年第1期217-221,共5页世界糖尿病杂志（英文）

基　　金：Supported by the National Natural Science Foundation of China,No.82400966;Guangdong Basic and Applied Basic Research Foundation,No.2021A1515111025;Science and Technology Projects in Guangzhou,No.2024A04J5170.

摘　　要：In this article,we review the study by Jin et al,which examined the role of intestinal glucagon-like peptide-1(GLP-1)in counterregulatory responses to hypoglycemia in patients with type 1 diabetes mellitus(T1DM).With the global rise of T1DM,there is an increased burden on society and healthcare systems.Due to insulin therapy and islet dysfunction,T1DM patients are highly vulnerable to severe hypoglycemia,a leading cause of mortality.In healthy individuals,counterregulatory mechanisms restore blood glucose during hypoglycemia,but repeated episodes impair these responses.Jin et al demonstrated that overexpression of GLP-1 attenuates the sympathetic-adrenal reflex and disrupts the secretion of counterregulatory hormones such as glucagon during hypoglycemia,leading to counterregulatory dysfunction.These findings highlight the critical role of GLP-1 in the impaired counterregulatory response to hypoglycemia in T1DM patients and provide new insights into the potential application of GLP-1-related therapies in T1DM patients.

关 键 词：Glucagon-like peptide-1 Impaired counterregulation Type 1 diabetes mellitus Sympathetic-adrenal reflex GLUCAGON 

分 类 号：R587.1[医药卫生—内分泌]