supported by grants from the National Natural Science Foundation of China(81930019)to Jin-Kui Yang;supported by grants from Beijing Municipal Natural Science Foundation(7232232)to Hao Wang。
Derived from enteroendocrine cells(EECs),glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic peptide(GIP)are pivotal incretin hormones crucial for blood glucose regulation.Medications of GLP-1 analogs a...
Supported by Mekong-Lancang Cooperation Special Fund;Cho-Kalaphruek Excellent Research Project for Medical Students;The International Internship Pilot Program,No.IIPP2023283.
Glucagon-like peptide-1 receptor(GLP-1R)agonist,a subgroup of incretin-based anti-diabetic therapies,is an emerging medication with benefits in reducing blood glucose and weight and increasing cardiovascular protectio...
Metabolic dysfunction-associated steatotic liver disease(MASLD)has become the most common chronic liver disease worldwide,paralleling the rising pandemic of obesity and type 2 diabetes.Due to the growing global health...
BACKGROUND It was reported that rikkunshito(TJ-43)improved the cisplatin-induced decreases in the active form of ghrelin in plasma;however,other effects on gastrointestinal hormones have not been investigated.AIM To i...
Common metabolic diseases,such as obesity and nonalcoholic steatohepatitis(NASH),are major public health concerns.The only therapeutic approach that offers weight loss of 20%or more is bariatric surgery.Medications ar...
supported by the National Natural Science Foundation of China (No. 82003873 and 81903708);the Postdoctoral Science Foundation of China (No. 2020M681899);the Fundamental Research Funds for the Central Universities (No. 2021QNA7019)。
The treatment of patients with diabetes mellitus, which is characterized by defective insulin secretion and/or the inability of tissues to respond to insulin, has been studied for decades. Many studies have focused on...
Fatty liver disease is defined as liver condition characterized by hepatic steatosis,closely related to pathological conditions in type 2 diabetes and obesity.The high prevalence of fatty liver disease in obese patien...
BACKGROUND Rikkunshito(TJ-43)relieves gastrointestinal disturbance by increases in the levels of acylated ghrelin.AIM To investigate the effects of TJ-43 in patients undergoing pancreatic surgery.METHODS Forty-one pat...
National Natural Science Foundation of China(No.72074011)
To the Editor:Incretin-based therapies for type 2 diabetes mellitus(T2DM)include incretin mimetics of glucagonlike peptide-1 receptor agonists(GLP-1 RAs)and incretin enhancers of dipeptidyl peptidase-4(DPP-4)inhibitor...
Incretin-based therapies like glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors help maintain the glycaemic control in patients with type 2 diabetes mellitus with additional systemic bene...