Chemical and chemoenzymatic stereoselectivesynthesis of β-nucleosides and their analogues  

作　　者：Hui-Jing Wang Yang-Yang Zhong You-Cai Xiao Fen-Er Chen 

机构地区：[1]Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,610041,China [2]Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University,Shanghai,200433,China [3]Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs,Shanghai 200433,ChinaShanghai,200433,China

出　　处：《Organic Chemistry Frontiers》2022年第6期1719-1741,共23页有机化学前沿（英文）

基　　金：support from the Fundamental Research Funds for the Central Universities(Grants YJ201853,YJ201805 and YJ202120);the National Natural Science Foundation(Grant 21907072).

摘　　要：β-Nucleosides are fundamental building blocks of biological systems and are widely used as therapeuticagents for the treatment of cancer and viral infections, among others. In the last two years, nucleosideanalogues have been investigated with renewed urgency in the search for agents that are effective againstSARS-CoV-2, the cause of the ongoing global pandemic of COVID-19. This has resulted in an explosionof activities in the field of β-nucleoside synthesis. This review summarizes the historical perspective andthe recent advances in the stereoselective synthesis of β-nucleosides and their analogues. The syntheticstrategies to obtain β-nucleosides can be divided into three categories: (1) N-glycosylation;(2) intramolecular sugar ring formation;and (3) enzymatic transglycosylation.

关 键 词：synthesis ANALOGUES NUCLEOSIDE 

分 类 号：O62[理学—有机化学]