Breakthrough in the challenging P450-catalyzed chemoenzymatic synthesis of C14-functionalized steroids  

作　　者：Manfred T.Reetz Frank Hollmann 

机构地区：[1]Max-Planck-Institut für Kohlenforschung,Kaiser-Wilhelm-Platz 1,45480 Mülheim,Germany [2]Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin 300308,China [3]Department of Biotechnology,Delft University,van der Maasweg 9,2629 HZ Delft,Netherlands

出　　处：《Science China Chemistry》2023年第9期2435-2436,共2页中国科学（化学英文版）

摘　　要：Intensive past research has demonstrated that cytochrome P450 monooxygenases are involved in the biosynthesis of numerous natural products and in human metabolism of various pharmaceuticals [1]. This inspired synthetic organic and pharmaceutical chemists to test them as catalysts in the oxidative hydroxylation of steroids. Unfortunately, wildtype P450s generally proved to show low levels of regio-and diastereoselectivity as well as suboptimal activity.

关 键 词：STEROIDS CATALYZED synthesis 

分 类 号：TQ460.1[化学工程—制药化工]