CABAZITAXEL

作品数：30被引量：37H指数：4
导出分析报告
相关领域：医药卫生更多>>
相关作者：李英霞赵砚荣宗在伟张国宁方唯硕更多>>
相关机构：复旦大学无锡靶点药物研究有限公司北京协和医学院药物研究所北京协和医院更多>>
相关期刊：《Acupuncture and Herbal Medicine》《药学进展》《Acta Pharmacologica Sinica》《中国处方药》更多>>
相关基金：国家自然科学基金天津市自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Fine-tuning the activation behaviors of ternary modular cabazitaxel prodrugs for efficient and on-target oral anti-cancer therapy
《Asian Journal of Pharmaceutical Sciences》2024年第2期188-203,共16页Mingyang Zhang Yifan Miao Can Zhao Tong Liu Xiyan Wang Zixuan Wang Wenxin Zhong Zhonggui He Chutong Tian Jin Sun 
supported by National Natural Science Foundation of China(No.82173766,82104109);Natural Science Foundation of Liaoning Province(2022-BS158);Liaoning Province Applied Basic Research Program(No.2022JH2/101300097);National Key R&D Program of China(No.2022YFE0111600).
The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking of disulfide bonds is triggered by small amounts of ...
关键词：Steric disulfide bond Triglyceride-like pr odrugs CABAZITAXEL Lymphatic transport Oral chemotherapy 
Ritonavir reverses resistance to docetaxel and cabazitaxel in prostate cancer cells with acquired resistance to docetaxel
《Cancer Drug Resistance》2024年第1期1029-1052,共24页Eric van der Putten Katja Wosikowski Jos H.Beijnen Gábor Imre Colin R.Freund 
supported by Modra Pharmaceuticals B.V..No other financial grants were provided.
Aim:Docetaxel is a microtubule-stabilizing drug used for the treatment of several cancers,including prostate cancer.Resistance to docetaxel can either occur through intrinsic resistance or develop under therapeutic pr...
关键词：Prostate cancer docetaxel resistance cabazitaxel resistance P-GP ritonavir 
A novel cabazitaxel liposomes modified with ginsenoside Rk1 for cancer targeted therapy
《Acupuncture and Herbal Medicine》2024年第1期113-121,共9页Dandan Huang Zhongjie Tang Xiao Pu Tianqi Wang Feiyan Gao Chong Li 
supported by the National Natural Science Foundation of China(82373808);Chongqing Natural Science Foundation(cstc2021jcyj-bshX0125);Fundamental Research Funds for the Central Universities(SWURC2020001);the project for Chongqing University Innovation Research Group,Chongqing Education Committee(CXQT20006).
Objective:In this study,we aim to enhance the anti-prostate cancer efficacy of cabazitaxel(CTX)and reduce its immunosuppression and systemic toxicity by developing CTX-loaded liposomes modified with ginsenoside Rk1(Rk...
关键词：CABAZITAXEL Fungal infection Ginsenoside Rk1 Liposome-drug delivery system Prostate cancer 
Feasibility of cabazitaxel in octogenarian prostate cancer patients
《Current Urology》2023年第3期153-158,共6页Paolo Tralongo Sebastiano Bordonaro Giuseppe Di Lorenzo Ugo De Giorgi NicolòBorsellino Gaetano Facchini Sabrina Rossetti Giuseppe Fornarini Vito Longo Antonino Carmelo Tralongo Francesca Caspani Massimiliano Spada Nicola Calvani Paolo Carlini 
Background:To evaluate the effectiveness and safety of cabazitaxel in castration-resistant prostate cancer patients aged>80 years,we performed a retrospective study on a sample of patients from 11 Italian cancer cente...
关键词：CABAZITAXEL CANCER OCTOGENARIAN PROSTATE 
All-stage targeted therapy for the brain metastasis from triple-negative breast cancer被引量：1
《Acta Pharmaceutica Sinica B》2023年第1期359-371,共13页Zimiao Luo Sunyi Wu Jianfen Zhou Weixia Xu Qianzhu Xu Linwei Lu Cao Xie Yu Liu Weiyue Lu 
supported by Shanghai Education Commission Major Project(No.2017-01-07-00-07-E00052,China);National Natural Science Foundation of China(Nos.81773657,81690263,and 81903547,China);Shanghai Sailing Program(No.20YF1404500,China)。
Brain metastasis is a common and serious complication of breast cancer,which is commonly associated with poor survival and prognosis.In particular,the treatment of brain metastasis from triplenegative breast cancer(BM...
关键词：Breast cancer Brain metastasis from breast cancer Platelet-hybrid liposome pVAP peptide Nanocrystal CABAZITAXEL Targeted drug delivery Drug delivery system 
Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel
《Nano Research》2022年第5期4302-4309,共8页Boyang Sun Sanjana Ghosh Xuedan He Wei-Chiao Huang Breandan Quinn Meiling Tian Dushyant Jahagirdar Moustafa T.Mabrouk Joaquin Ortega Yumiao Zhang Shuai Shao Jonathan F.Lovell 
This study was supported by the National Institutes of Health(No.R01EB017270);The National Natural Science Foundation of China(No.82001752)。
Photodynamic therapy(PDT)is a non-invasive tumor ablation modality that can be enhanced in combination with concurrent chemotherapy.Previously,we demonstrated that liposomes containing a bilayer-anchored photosensitiz...
关键词：photodynamic therapy CABAZITAXEL LIPOSOME chemotherapy porphyrin-phospholipid 
Acid-sensitive PEGylated cabazitaxel prodrugs for antitumor therapy
《Chinese Chemical Letters》2021年第5期1751-1754,共4页Tao Liu Hui Zou Jingqing Mu Na Yu Yang Xu Guohua Liu Xingjie Liang Shutao Guo 
This work was supported by the National Natural Science Foundation of China(No.51773098);the Natural Science Foundation of Tianjin of China(No.18JCYBJC28300);the Fundamental Research Funds for Central Universities(China).
Although the antitumor drug cabazitaxel shows great therapeutic potential,its high toxicity and poor water solubility limit its utility.However,the use of stimuli-responsive prodrugs is a promising strategy for overco...
关键词：PRODRUGS Acid-sensitive Antitumor therapy CABAZITAXEL PEGYLATION 
A facile and universal method to achieve liposomal remote loading of non-ionizable drugs with outstanding safety profiles and therapeutic effect被引量：3
《Acta Pharmaceutica Sinica B》2021年第1期258-270,共13页Shuang Zhou Jinbo Li Jiang Yu Liyuan Yang Xiao Kuang Zhenjie Wang Yingli Wang Hongzhuo Liu Guimei Lin Zhonggui He Dan Liu Yongjun Wang 
financially supported by the National Nature Science Foundation of China(U1608283);the Career Development Program for Young and Middle-aged Teachers in Shenyang Pharmaceutical University
Liposomes have made remarkable achievements as drug delivery vehicles in the clinic.Liposomal products mostly benefited from remote drug loading techniques that succeeded in amphipathic and/or ionizable drugs,but seem...
关键词：Non-ionizable drugs Weak acid derivatives Remote loading liposome CABAZITAXEL Safety Tolerated doses Cancer Lung metastasis 
A cabazitaxel liposome for increased solubility, enhanced antitumor effect and reduced systemic toxicity被引量：5
《Asian Journal of Pharmaceutical Sciences》2019年第6期658-667,共10页Xiaoyi Yin Lihua Luo Wei Li Jie Yang Chunqi Zhu Mengshi Jiang Bing qin Xiaoling Yuan Hang Yin Yichao Lu Yongzhong Du Dawei Chen Jian You 
supported by the National Key R&D Program of China(No.2017YFE0102200);the Natural Science Foundation of China(81373348 and 81573365);Basic Public Welfare Re-search Project of Zhejiang Province,China(LGF18H300004)
The potential side effects of cabazitaxel(CBZ)in the field of cancer treatment have become a great limitation to its further clinical application.Liposomal delivery is a well-established approach to increase the thera...
关键词：CABAZITAXEL LIPOSOME Stability Apoptosis BIOSAFETY 
Impact of taxanes on androgen receptor signaling被引量：1
《Asian Journal of Andrology》2019年第3期249-252,共4页Shanshan Bai Bryan Y Zhang Yan Dong 
the following grants: National Institutes ofHealth/National Cancer Institute (NIH/NCI) RO1 CAI88609, Department of Defense W81XWH-15-1-0439, W81XWH-16-1-0317, and W81XWH-14-1-0485;National Natural Science Foundation of China Project 81430087.
The development and progression of metastatic castration-resistant prostate cancer is the major challenge in the treatment of advanced prostate cancer. The androgen receptor signaling pathway remains active in metasta...
关键词：ANDROGEN RECEPTOR ANDROGEN RECEPTOR splice variant CABAZITAXEL DOCETAXEL prostate cancer TAXANE 
全选清除导出
共3页<123>
检索报告 对象比较 聚类工具 使用帮助 返回顶部