funded by National Natural Science Foundation of China(32360564);the Natural Science and Technology Innovation Development Multiplication Plan of Guangxi University(2022BZRC010)。
Hyperuricemia(HUA)is characterized by elevated levels of uric acid(UA)in the bloodstream,resulting from either excessive production or insufficient excretion of UA within the body.If left untreated,progressive or pers...
The study by Lin et al delves into the clinical impact of dapagliflozin,a repre-sentative sodium-glucose cotransporter 2(SGLT2)inhibitor,on chronic heart failure complicated by hyperuricemia.This investigation highlig...
supported by the National Natural Science Foundation of China(Grant Nos.82373715,32171479,82304784);the Major Science and Technology Project of Anhui Province(Grant No.202303a07020007);the CASHIPS Director’s Found(Grant No.BJPY2022A02).
Abnormal activation of NLRP3 inflammasome causes the progression of gout,and no small-molecule inhibitor of NLRP3 has been approved yet for clinical use.In this study we established a nigericin-induced inflammasome ac...
Objective:To explore the mechanism of action of"Weilingxian-Guizhi"two drugs in the treatment of gout.Method:First obtain the 15 chemical components contained in the"Weilingxian-Guizhi"drug,predict its target points t...
Objectives:This study aimed to explore the preferences and influencing factors of self-management behaviors in patients with recurrent gout and provide a theoretical basis for developing targeted strategies to improve...
Acute articular rheumatism(AAR)primarily affects children aged 5 to 15,causing fever and non-suppurative arthritis,and can lead to severe heart problems such as mitral stenosis and aortic insufficiency.Descriptions of...
National Key R&D Programme Project(2022YFC3501200);Zhejiang Provincial Science and Technology Programme Project(2023C03040);State Administration of Traditional Chinese Medicine Science and Technology Department-Zhejiang Provincial Administration of Traditional Chinese Medicine Joint Project(GZY-ZJ-KJ-23009).
Background:Gout is a metabolic rheumatic disease that seriously endangers human health,with a relatively high prevalence and disability rate worldwide.Current international clinical practice guidelines provide recomme...
funded by National Natural Science Foundation of China(21868003);Bama County Program for Talents in Science and Technology(BaRenKe20210045).
The traditional nutritional and medical hemp(Cannabis sativa L.)seed protein were explored for the discovery and directional preparation of new xanthine oxidase inhibitory(XOI)peptides by structure-based virtual scree...
Supported by Zhejiang Province Leading Geese Program,No.2024C03218;Research Project of Jinan Microecological Biomedicine Shandong Laboratory,No.JNL-2023010Q.
In this manuscript,we comment on the article by Liu et al published in the recent issue of the journal.Hyperuricemia(HUA)has become the second most common metabolic disease after type 2 diabetes mellitus and is the mo...
supported by grants from the National Natural Science Foundation of China(No.32270947);Yunnan Applied Basic Research Projects,Kunming Medical University Union Special Fund(No.202301AY070001-043,No.202301AY070001-159);The Ten Thousand Scientists Program of Yunnan Province(No.YN-WR-MY-2018-040,No.YNWR-QNBJ-2018-152);535 Talent Project of First Affiliated Hospital of Kunming Medical University(No.2022535Q01);Yunnan Clinical Center for Skin Immune Diseases(No.ZX2019-03-02).
A 32-year-old male patient with gout presented to First Affiliated Hospital of Kunming Medical University for the first time,complaining of intermittent knee and ankle pain for the past 4 years.The highest level of hi...