Roles of traditional Chinese medicine extracts in hyperuricemia and gout treatment:Mechanisms and clinical applications  

作　　者：Yan-Bo Wang Chang-Zhong Jin 

机构地区：[1]Department of Cell Biology,Jinan Microecological Biomedicine Shandong Laboratory,Jinan 250117,Shandong Province,China [2]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,Zhejiang University,Hangzhou 310003,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2024年第47期5076-5080,共5页世界胃肠病学杂志（英文）

基　　金：Supported by Zhejiang Province Leading Geese Program,No.2024C03218;Research Project of Jinan Microecological Biomedicine Shandong Laboratory,No.JNL-2023010Q.

摘　　要：In this manuscript,we comment on the article by Liu et al published in the recent issue of the journal.Hyperuricemia(HUA)has become the second most common metabolic disease after type 2 diabetes mellitus and is the most important risk factor for gout.This discussion focuses on the targets and clinical application value of traditional Chinese medicine(TCM)extracts in the treatment of HUA and gout,emphasizing the role of gut microbiota.Liu et al’s study demonstrated that Poecilobdella manillensis protein extract alleviated HUA through multiple mechanisms,including inhibition of uric acid(UA)reabsorption,promotion of UA excretion,repair of intestinal barrier function,and regulation of gut microbiota and metabolome.Unlike the commonly used urate-lowering drugs such as allopurinol and febuxostat,which have clear and single targets,many TCMs have multi-target effects.However,the active components and mechanisms of TCMs are not fully understood,limiting their clinical application in the treatment of HUA and gout.Additionally,the role of gut microbiota in UA metabolic homeostasis needs to be further explored.

关 键 词：HYPERURICEMIA GOUT Traditional Chinese medicine Gut microbiota Multitarget Uric acid metabolic homeostasis 

分 类 号：R259[医药卫生—中西医结合]