云南高校图书馆联盟文献共享服务平台- TUBULIN

TUBULIN: 作品数：126被引量：202H指数：6; 导出分析报告; 相关作者：郑丽祯董辰方王瑞元李俊平刘晓然更多>>; 相关机构：南方医科大学中山大学安徽医科大学附属省立医院西安交通大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金湖北省自然科学基金更多>>

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice: 《Neural Regeneration Research》2025年第8期2348-2360,共13页Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel; supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Alzheimer Forschung Initiative e.V.(grant#22039,to HZ);open-access funding from the DFG/GRC issued to the University of Cologne;Alzheimer Forschung Initiative e.V.for Open Access Publishing(a publication grant#P2401,to MAAK)。; TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal...; 关键词：human induced pluripotent stem cell MICROTUBULES P301L pR5 mice TAU TAUOPATHY tubulin code

N-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers:Design,structure-activity relationships and biological evaluations: 《Chinese Chemical Letters》2025年第2期228-233,共6页Jian Song Shenghui Wang Qiuge Liu Xiao Wang Shuo Yuan Hongmin Liu Saiyang Zhang; supported by the National Natural Science Foundation of China(Nos.82273782 and U2004123);Training Program for Young Key Teachers of Colleges and Universities in Henan Province(No.2023GGJS008)。; In this work,we employed a ring-opening strategy to develop a series of novel N-benzyl arylamide derivatives as tubulin polymerization inhibitors.Notably,13n(MY-1388)exhibited remarkable antiproliferative potency on f...; 关键词：TUBULIN Colchicine binding site CA-4 N-Benzyl arylamide Antiproliferative activities

Inhibition of tubulin detyrosination:a novel strategy to promote central nervous system regeneration: 《Neural Regeneration Research》2024年第12期2557-2558,共2页Charlotte Zeitler Marco Leibinger Dietmar Fischer; The adult mammalian central nervous system(CNS) coordinates essential functions such as sensation,movement,autonomic control,thought processes,and communication.Consequently,injuries or diseases of the CNS are often a...; 关键词：INJURIES SENSATION DISEASES

An improved method for tubulin staining of ciliated eukaryotes: 《Water Biology and Security》2024年第3期65-71,共7页Tingting Pan Jing Zhang Che Hu Guanxiong Yan Weiwei Qin Zixin Cheng Dongxia Yuan Fang Zhou Jie Xiong Wei Miao Chuanqi Jiang; supported by the Third Xinjiang Scientific Expedition Program(2021xjkk0204,2021xjkk0604);Science&Technology Fundamental Resources Investigation Program(2022FY100400);Background Resources Survey in Shennongjia National Park(SNJNP2022008);Hubei Provincial Key Laboratory for Conservation Biology of Shennongjia Snub-nosed Monkeys(SNJGKL2022008);Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation,Beibu Gulf University(2020KA05).; Ciliated microeukaryotes(ciliates)are distinguished by their cilia,which are rich in tubulin.We developed a method for tubulin staining in ciliate cells that involves using live-cell tubulin-staining dyes instead of a...; 关键词：CILIATE CILIUM Live-cell tubulin dye Tubulin staining

Adenine nucleotide translocase 2(Ant2)is required for individualization of spermatogenesis of Drosophila melanogaster: 《Insect Science》2024年第4期1055-1072,共18页Zhen He Yang Fang Fengchao Zhang Yang Liu Xinkai Cheng Jiajia Wang Dechen Li Dengsong Chen Fan Wu; supported by China Agriculture Research System of MOF and MARA(CARS-18-SYZ10);Hubei Province Agricultural Science and Technology Innovation Center Project(2021-620-000-001-009);Hubei Province Key Research and Development Project(2022BBA0079).; Successful completion of spermatogenesis is crucial for the perpetuation of the species.In Drosophila,spermatid individualization,a process involving changes in mitochondrial structure and function is critical to prod...; 关键词：adenine nucleotide translocase Drosophila melanogaster individualization complexes MITOCHONDRIA SPERMATOGENESIS tubulin polyglycylation

Potential role of tubulin glutamylation in neurodegenerative diseases: 《Neural Regeneration Research》2024年第6期1191-1192,共2页Abdullah Md.Sheikh Shatera Tabassum; The differentiation of neuronal stem cells into mature neurons is a complex process that involves both structural and functional changes.As cells undergo differentiation,there are notable functional changes,including ...; 关键词：DISEASES DEGENERATIVE CYTOKINES

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia: 《Current Medical Science》2024年第2期298-308,共11页Zhen LU Qian LAI Zhi-feng LI Meng-ya ZHONG Yue-long JIANG Li-ying FENG Jie ZHA Jing-wei YAO Yin LI Xian-ming DENG Bing XU; funded by the National Natural Science Foundation of China(No.81770126,No.81900160,No.81800163,No.22025702,and No.91853203);the Fujian Natural Science Foundation of China(No.2020J011246 and No.2021J011359);the Foundation of Health and Family Planning Commission of Fujian Province of China(No.2020GGB054);the Xiamen Municipal Bureau of Science and Technology(No.3502Z20209003);the Fundamental Research Funds for the Central Universities of China(No.20720190101).; Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic r...; 关键词：B-cell acute lymphoblastic leukemia dual-target inhibitor NF-KB c-Myc PI3K/AKT p53

以Tubulin为靶点的甲苯哒唑靶向制剂在抗乳腺癌中的作用研究: 《中文科技期刊数据库（全文版）医药卫生》2024年第4期0139-0141,共3页姚凯鄢荣曾王飞黎乃维; 江西省卫健委科技计划项目以微管蛋白为靶点的甲苯哒唑新剂型在抗乳腺癌作用研究(202212882)。; 截止到2023年世界癌症日的相关数据报道,乳腺癌已经是全球第一大癌症,其中三阴性乳腺癌(TNBC)是一种异质性、侵袭性乳腺癌表型,具有相关的化疗耐药性。化学或放射抗性的发展可归因于不同的肿瘤微环境、膜蛋白(转运蛋白)的过度表达、表...; 关键词：甲苯哒唑三阴性乳腺癌微管蛋白有丝分裂

Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma: 《Acta Pharmacologica Sinica》2023年第11期2265-2281,共17页Joelle C.Boulos Ejlal A.Omer Daniela Rigano Carmen Formisano Manik Chatterjee Ellen Leich Sabine M.Klauck Le-tian Shan Thomas Efferth; funded by a private donation of Marc Strobel,Frankfurt,Germany;by the Deutsche Krebshilfe(process number:70112693 to EL)。; The majority of blood malignancies is incurable and has unforeseeable remitting-relapsing paths in response to different treatments. Cynaropicrin, a natural sesquiterpene lactone from the edible parts of the artichoke...; 关键词：hematological malignancies multiple myeloma cynaropicrin C-MYC MICROTUBULES parthanatos network pharmacology xenograft tumor zebrafish model

Cryo-EM of α-tubulin isotype-containing microtubules revealed a contracted structure of α4A/β2A microtubules: 《Acta Biochimica et Biophysica Sinica》2023年第10期1551-1560,共10页Lei Diao Wei Zheng Qiaoyu Zhao Mingyi Liu Zhenglin Fu Xu Zhang Lan Bao Yao Cong; supported by the grants from the National Natural Science Foundation of China(Nos.31991194,31330046,and 32130056);the Strategic Priority Research Program of Chinese Academy of Sciences(Nos.XDB19000000 and XDB37040103);the National Key R&D Program of China(No.2017YFA0503503);Shanghai Academic Research Leader(No.20XD1404200);Shanghai Pilot Program for Basic Research from CAS(No.JCYJSHFY-2022-008).; Microtubules are hollow α/β-tubulin heterodimeric polymers that play critical roles in cells.In vertebrates,both α-and β-tubulins have multiple isotypes encoded by different genes,which are intrinsic factors in re...; 关键词：microtubule tubulin isotype α4A cryo-EM structure

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

TUBULIN

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

TUBULIN

检索结果分析

下载全文

用户登录

高级检索检索式检索