PHOSPHOPROTEOMICS

作品数：25被引量：27H指数：3
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相关领域：生物学更多>>
相关作者：林韵宋丽娜卢庄薛宇刘金风更多>>
相关机构：中山大学华中科技大学北京蛋白质组研究中心武汉大学更多>>
相关期刊：《Chinese Medical Journal》《Signal Transduction and Targeted Therapy》《Molecular Plant》《Journal of Traditional Chinese Medicine》更多>>
相关基金：国家自然科学基金广东省自然科学基金中国博士后科学基金北京市科技计划项目更多>>
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Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors
《Acta Pharmacologica Sinica》2025年第3期702-714,共13页Lin-hui Zhai Xing-long Jia Yu-lu Chen Mu-yin Liu Jing-dan Zhang Shao-jie Ma Xiu-jun Wang Wen-hao Cheng Jing-liang He Jiao-jiao Zhou Ling-yi Zuo Mei-qi Zhang Qing Yuan Meng-han Xu Jing Ji Min-jia Tan Bin Liu 
supported by grants from the National Natural Science Foundation of China(82273167,22225702,32171434);the Program of Shanghai Academic Research Leader(22XD1420900);the State Key Laboratory of Drug Research(SIMM2105KF-13);Jiangsu Province Basic Research Program Natural Science Foundation(Outstanding Youth Fund Project,BK20220063);the Key Program of Basic Science(Natural Science)of Jiangsu Province(22KJA350001);“Huaguo Mountain Talent Plan”of Lianyungang City(Innovative Talents to Bin Liu).
Colchicine is a widely prescribed anti-inflammatory drug for the treatment of gout,familial Mediterranean fever and pericarditis,but its narrow therapeutic window presents a significant risk of severe toxicity.Despite...
关键词：COLCHICINE MLN4924 multi-omics analysis PHOSPHOPROTEOMICS ubiquitinomics kinase inhibitor 
Quantitative phosphoproteomics reveals molecular pathway network in wheat resistance to stripe rust
《Stress Biology》2024年第1期321-335,共15页Pengfei Gan Chunlei Tang Yi Lu Chenrong Ren Hojjatollah Rabbani Nasab Xufeng Kun Xiaodong Wang Liangzhuang Li Zhensheng Kang Xiaojie Wang Jianfeng Wang 
supported by the National Natural Science Foundation of China(32161143023,32225041);the earmarked fund for CARS(CARS-03);Science and Technology Assistance Project of Xinjiang Uygur Autonomous Region(2022E02070),and Tang Scholar.
Protein phosphorylation plays an important role in immune signaling transduction in plant resistance to pathogens.Wheat stripe rust,caused by Puccinia striiformis f.sp.tritici(Pst),severely devastates wheat production...
关键词：WHEAT Puccinia striiformis f.sp.tritici PHOSPHOPROTEOMICS 
Mechanisms of Dangua Fang(丹瓜方)in multi-target and multi-method regulation of glycolipid metabolism based on phosphoproteomics
《Journal of Traditional Chinese Medicine》2024年第2期334-344,共11页HENG Xianpei WANG Zhita LI Liang YANG Liuqing HUANG Suping JIN Lang HE Weidong 
the National Natural Science Foundation of China:Based on the"miR34a/Nampt-NAD+-TAC"Pathway to Study the Mechanism of Simultaneously Treating the Phlegm and Blood Stasis in the Regulation of Glycolipid(No.81873213);Study on the Mechanism of Simultaneously Treating the Phlegm and Blood Stasis on Glycolipid Metabolism Based on Intestinal Fat Absorption Regulated by miR-34a/Stat3-Nfil3 Pathway(82074308);a New Mechanism of Regulating the Amino Acid Metabolism of Type 2 Diabetes Mellitus with Dissipating Phlegm-Stasis:Based on the TCA Cycle-Mediated Transformation of"α-KG→Glutamate"(82274389);by Industry-University Cooperation Project for University in Fujian Province:Preparation of Monomeric Traditional Chinese Medicine Complexes Based on Nampt's Activation of Tricarboxylic Acid Cycle and Respiratory Chain to Interfere with Glycolipid Metabolism(2022Y41010015)。
OBJECTIVE:To explore the mechanism of Dangua Fang(丹瓜方,DGR)in multi-target and multi-method regulation of glycolipid metabolism based on phosphoproteomics.METHODS:Sprague-Dawley rats with normal glucose levels were ...
关键词：PHOSPHOPROTEOMICS glycolipid metabolism therapeutic mechanism compound formula Dangua Fang 
GreenPhos,a universal method for in-depth measurement of plant phosphoproteomes with high quantitative reproducibility
《Molecular Plant》2024年第1期199-213,共15页Xiaoxiao Duan Yuanya Zhang Xiahe Huang Xiao Ma Hui Gao Yan Wang Zhen Xiao Chengcheng Huang Zhongshu Wang Bolong Li Wenqiang Yang Yingchun Wang 
support from the Ministry of Science and Technology of the People's Republic of China(2019YFA0707100,2019YFA0802203);Strategic Priority Research Program of Chinese Academy of Sciences(XDA24040202);National Key Research and Development Program of China(2022YFF1001704)。
Protein phosphorylation regulates a variety of important cellular and physiological processes in plants.In-depth profiling of plant phosphoproteomes has been more technically challenging than that of animal phosphopro...
关键词：plant phosphoproteomics PHOSPHOPEPTIDES LC–MS ARABIDOPSIS salt stress 
Reversible protein phosphorylation, a central signaling hub to regulate carbohydrate metabolic networks
《The Crop Journal》2023年第5期1279-1286,共8页Fengyi Gao Liang Zhang James RLloyd Wenbin Zhou Yanmei Chen 
supported by the National Natural Science Foundation of China (32170409, 32370430);National Key Research and Development Program of China (2023YFE0109500)。
Plants produce a range of carbohydrates to meet their growth and developmental needs. Protein reversible phosphorylation plays key roles in coordinating multiple metabolic pathways and integrating diverse internal and...
关键词：Crop plants Metabolomics SnRK kinase TOR kinase Transcription factor PHOSPHOPROTEOMICS 
基于数据独立采集的磷酸化蛋白质组学全面揭示I型酪蛋白激酶在植物发育中的作用被引量：2
《Science Bulletin》2023年第18期2077-2093,M0004,共18页渠莉 刘默洋 郑玲丽 王旭 薛红卫 
supported by the National Natural Science Foundation of China(91954206,31721001,and 32100588).
I型酪蛋白激酶(CKI)是一类真核生物中高度保守的丝氨酸/苏氨酸蛋白激酶,通过介导底物的磷酸化调节生长发育和信号转导:拟南芥蛋白AELs,是植物特异的CK1,具有多种功能,但其内源底物的准确识别和验证极大地限制了对CK1生理功能的系统阐明...
关键词：Casein kinase 1(CK1) Arabidopsis EL1-like(AEL) Data-independent acquisition(DIA) PHOSPHOPROTEOMICS C3H17 Embryo development 
Integrated proteomic and phosphoproteomic data-independent acquisition data evaluate the personalized drug responses of primary and metastatic tumors in colorectal cancer
《Biophysics Reports》2023年第2期67-81,共15页Xumiao Li Yiming Huang Kuo Zheng Guanyu Yu Qinqin Wang Lei Gu Jingquan Li Hui Wang Wei Zhang Yidi Sun Chen Li 
supported by the National Natural Science Foundation of China(NSFC)(82030099,82072750,30700397);the Shanghai Municipal Science and Technology Commission"Science and Technology Innovation Action Plan"technical standard project(21DZ2201700);the Natural Science Fund of Shanghai(20ZR1457200);Shanghai Sailing Program(21YF1459300);the innovative research team of high-level local universities in Shanghai。
Mass spectrometry(MS)-based proteomics and phosphoproteomics are powerful methods to study the biological mechanisms,diagnostic biomarkers,prognostic analysis,and drug therapy of tumors.Dataindependent acquisition(DIA...
关键词：Proteomics PHOSPHOPROTEOMICS Data-independent acquisition(DIA) Mini patient derived xenograft(MiniPDX) Kinase-substrate network Personalized drug responses 
A basic phosphoproteomic-DIA workflow integrating precise quantification of phosphosites in systems biology
《Biophysics Reports》2023年第2期82-98,共17页Yi Di Wenxue Li Barbora Salovska Qian Ba Zhenyi Hu Shisheng Wang Yansheng Liu 
Phosphorylation is one of the most important post-translational modifications(PTMs)of proteins,governing critical protein functions.Most human proteins have been shown to undergo phosphorylation,and phosphoproteomic s...
关键词：Bioinformatic analysis High-resolution mass spectrometry technology PHOSPHOPROTEOMICS Systems biology Systems medicine 
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes被引量：1
《Signal Transduction and Targeted Therapy》2023年第3期1318-1331,共14页Pedro Casado Ana Rio-Machin Juho JMiettinen Findlay Bewicke-Copley Kevin Rouault-Pierre Szilvia Krizsan Alun Parsons Vinothini Rajeeve Farideh Miraki-Moud David CTaussig Csaba Bödör John Gribben Caroline Heckman Jude Fitzgibbon Pedro R.Cutillas 
We thank Adrian Kontor for technical help with the manipulation of AML primary samples,Sarah Mueller for managing the supply of AML primary samples,Janet Matthews for assisting with the processing of patient clinical data,Ruth Osuntola for technical assistance with the mass spectrometry experiments and the FIMM High Throughput Biomedicine Unit for their expert technical support.This work was mainly funded by Cancer Research UK(C15966/A24375)with additional contribution from Blood Cancer UK(20008).All authors have read and approved the article.
Acute myeloid leukaemia(AML)patients harbouring certain chromosome abnormalities have particularly adverse prognosis.For these patients,targeted therapies have not yet made a significant clinical impact.To understand ...
关键词：metabolism signature biologically 
Comparative phosphoproteomics reveal new candidates in the regulation of spermatogenesis of Drosophila melanogaster被引量：1
《Insect Science》2022年第6期1703-1720,共18页Bin Mao Wei Zhang Ya Zheng Dong Li Meng-Yan Chen Yu-Feng Wang 
supported by the National Natural Science Foundation of China(no.31672352,31872288).
The most common phenotype induced by the endosymbiont Wolbachia in in-sects is cytoplasmic incompatibility,where none or fewer progenies can be produced when Wolbachia-infected males mate with uninfected females.This ...
关键词：Drosophila melanogaster individualization complex PHOSPHOPROTEOME Slmap SPERMATOGENESIS 
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