INTERACTOME

作品数：51被引量：90H指数：4
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相关领域：生物学医药卫生更多>>
相关作者：贺敏崔艳艳冯雅琴李巍何新更多>>
相关机构：清华大学中国科学院遗传与发育生物学研究所哈尔滨医科大学中国农业科学院深圳农业基因组研究所更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Science China(Life Sciences)》《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system
《Neural Regeneration Research》2025年第8期2420-2432,共13页Lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li 
supported by the National Nature Science Foundation of China,No.32101020(to JL);the Natural Science Foundation of Shandong Province,Nos.ZR2020MC071(to JL),ZR2023MH327(to HZ);the Integrated Project of Major Research Plan of National Natural Science Foundation of China,No.92249303(to PL);the Natural Science Foundation of Qingdao,No.23-2-1-193-zyyd-jch(to HZ)。
The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKS...
关键词：autism spectrum disorder CENTROSOME CNKSR2 intellectual disability INTERACTOME mass spectrometry MICROTUBULE neurodevelopmental disease protein complexes protein-protein interactions 
A Novel Approach for Screening Salinity-Tolerant Rice Germplasm by Exploring Redox-Regulated Cytological Fingerprint
《Rice science》2025年第2期228-242,I0047-I0050,共19页Uthpal Krishna ROY Babita PAL Soumen BHATTACHARJEE 
supported by the Department of Science and Technology-Fund for improvement of Science and Technology Infrastructure,Government of India,for Instrumentation Facilities(Grant No.SR/FST/LS-1/2018/188©);the Indian Council for Cultural Relations under the India Scholarships Scheme(Grant No.DAC/EDU/17/1/2016);the Council of Scientific and Industrial Research,New Delhi,India(Grant No.09/025(0260)/2018-EMR-I).
Although metabolic homeostasis disruption,cellular damage,and premature senescence caused by salinity stress are well-documented in the literature,there are few studies investigating cytological changes induced by sal...
关键词：salinity stress cytological change chromosomal aberration coastal rice landrace metabolic homeostasis redox interactome 
Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets
《Neural Regeneration Research》2025年第3期725-739,共15页Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler 
funded by NIH-NIA R01AG061708 (to PHO);Patrick Grange Memorial Foundation (to PHO);A Long Swim (to PHO);CureSPG4 Foundation (to PHO)。
Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understan...
关键词：ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST SPASTIN 
Overlap in oncogenic and pro-inflammatory pathways associated with areca nut and nicotine exposure
《Cancer Pathogenesis and Therapy》2024年第3期187-194,共8页Krati Garg Anuj Kumar Vidisha Kizhakkethil Pramod Kumar Shalini Singh 
supported by intramural funding from the National Institute of Cancer Prevention and Research,Indian Council of Medical Research(No.NICPR/Anuj/intramural/2021/1).
Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of cancer.Unlike other psychoactive substances,such as nicotine,the mechanisms...
关键词：Cancer Areca nut NICOTINE INTERACTOME Cell signaling 
eRNA-IDO:A One-stop Platform for Identification,Interactome Discovery,and Functional Annotation of Enhancer RNAs
《Genomics, Proteomics & Bioinformatics》2024年第4期169-179,共11页Yuwei Zhang Lihai Gong Ruofan Ding Wenyan Chen Hao Rong Yanguo Li Fawziya Shameem Korakkandan Arshad Ali Lei Li Qi Liao 
supported by the National Natural Science Foundation of China(Grant Nos.32300430,32100533,and 31970630);the Open Grant Funds from Shenzhen Bay Laboratory(Grant No.SZBL2021080601001 to Lei Li);the Zhejiang Provincial Natural Science Foundation of China(Grant No.LY21C060002);the Ningbo Major Research and Development Plan Project(Grant Nos.2023Z226 and 2023Z171),China.
Growing evidence supports the transcription of enhancer RNAs(eRNAs)and their important roles in gene regulation.However,their interactions with other biomolecules and their corresponding functionality remain poorly un...
关键词：Enhancer RNA IDENTIFICATION INTERACTOME Functional annotation Web server 
Multiplexed stimulated emission depletion nanoscopy(mSTED)for 5-color live-cell long-term imaging of organelle interactome被引量：1
《Opto-Electronic Advances》2024年第7期17-26,共10页Yuran Huang Zhimin Zhang Wenli Tao Yunfei Wei Liang Xu Wenwen Gong Jiaqiang Zhou Liangcai Cao Yong Liu Yubing Han Cuifang Kuang Xu Liu 
supported by the following grants:National Natural Science Foundation of China(62125504,62361166631);STI 2030-Major Projects(2021ZD0200401);the Fundamental Research Funds for the Central Universities(226-2022-00201);the Open Project Program of Wuhan National Laboratory for Optoelectronics(2021WNLOKF007).
Stimulated emission depletion microscopy(STED)holds great potential in biological science applications,especially in studying nanoscale subcellular structures.However,multi-color STED imaging in live-cell remains chal...
关键词：optical nanoscopy phasor analysis multicolor live cell imaging 
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge
《Chinese Journal of Natural Medicines》2024年第5期385-386,共2页CHEN Qian FAN Xiaohui 
This work is supported by the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(No.2024C03106);Ningbo Top Medical and Health Research Program(No.2022030309)。
With the awarding of the 2015 Nobel Prize in Physiology or Medicine to Chinese pharmacologist Tu Youyou,and the significant contributions of traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),TCM ...
关键词：Protein interactome Traditional Chinese medicine Therapeutic effectiveness 
Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice
《Protein & Cell》2024年第4期261-284,共24页He-Zhou Huang Wen-Qing Ai Na Wei Ling-Shuang Zhu Zhi-Qiang Liu Chao-Wen Zhou Man-Fei Deng Wen-Tao Zhang Jia-Chen Zhang Chun-Qing Yang Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Jun Jia Jing Wang Fang-Fang Liu Ke Li Qi Xu Mei Yuan Hengye Man Ziyuan Guo Youming Lu Kai Shu Ling-Qiang Zhu Dan Liu 
supported partially by the National Key Research and Development Program of China(Grant Nos.2019YFE0121200,2022YFC2403905);the National Natural Science Foundation of China(Grant Nos.82325017,82371403,82030032,82261138555,31721002,32070960,82001164,82001256);Top-Notch Young Talents Program of China of 2014,the China Postdoctoral Science Foundation(Grant No.2018M642855);the Hubei Provincial Natural Science Foundation(Grant No.2022CFA004 to Dr.Ling-Qiang Zhu,2023AFA068 to Dr.Dan Liu,2020CFB657 to Dr.Kai Shu);University of South China Clinical Research 4310 Program(Grant No.20224310NHYCG08);the Science and Technology Innovation Program of Hunan Province(Grant No.2022RC4044);The Key R&D and Promotion Program of Henan Science and Technology Department(Grant Nos.182102310512,202102310354,222102310084);the Henan Province Medical Science and Technology Research Project(Grant No.SBGJ202103052).
Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family history.Although genome-wide association studies have identified associated risk genes and...
关键词：Alzheimer’s disease memory impairment synaptic disorder tau pathology 
Disease networks. Uncovering disease-disease relationships through the incomplete interactome
《四川生理科学杂志》2024年第4期772-772,共1页Jörg Menche 
According to the disease module hypothesis,the cellular components associated with a disease segregate in the same neighborhood of the human interactome,the map of biologically relevant molecular interactions.Yet,give...
关键词：INCOMPLETE NEIGHBORHOOD network 
Disease networks. Uncovering disease-disease relationships through the incomplete interactome
《四川生理科学杂志》2024年第1期199-199,共1页Jorg Menche 
According to the disease module hypothesis,the cellular components associated with a disease segregate in the same neighborhood of the human interactome,the map of biologically relevant molecular interactions.Yet,give...
关键词：INCOMPLETE interactions. networks. 
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