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NICOTINE: 作品数：206被引量：545H指数：10; 导出分析报告; 相关领域：医药卫生环境科学与工程更多>>; 相关作者：陈汝筑朱小南高静邓春玉孔令龙更多>>; 相关机构：湖南农业大学中山医科大学广州医科大学上海大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金广东省自然科学基金更多>>

Modulation of Nicotine-Associated Behaviour in Rats Byμ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell: 《Neuroscience Bulletin》2024年第12期1826-1842,共17页Feng Zhu Hirosato Kanda Hiroyuki Neyama Yuping Wu Shigeki Kato Di Hu Shaoqi Duan Koichi Noguchi Yasuyoshi Watanabe Kazuto Kobayashi Yi Dai Yilong Cui; supported by JSPS KAKENHI(24659574,26112003,and 15K14328),and JP 16H06276(AdAMS).; Nicotine addiction is a concern worldwide.Most mechanistic investigations are on nicotine substance dependence properties based on its pharmacological effects.However,no effective therapeutic treatment has been establ...; 关键词：Nicotine-associated behaviour μ-Opioid receptor Medial prefrontal cortex Nucleus accumbens shell Small-animal neuroimaging

Nicotine-induced transcriptional changes and mitochondrial dysfunction in the ventral tegmental area revealed by single-nucleus transcriptomics: 《Journal of Genetics and Genomics》2024年第11期1237-1251,共15页Lei Fan Boxin Liu Ru Yao Xia Gao Hongjuan Wang Sanjie Jiang Xiaomin Zheng Huan Chen Hongwei Hou Yong Liu Qingyuan Hu; supported by the Major Project of Tobacco Biological Effects(552022AK0070,110202102014)。; Nicotine is widely recognized as the primary contributor to tobacco dependence.Previous studies have indicated that molecular and behavioral responses to nicotine are primarily mediated by ventral tegmental area(VTA)n...; 关键词：Single-nucleus transcriptomics Ventral tegmental area Nicotine addiction Cell-type-specific alteration Mitochondrial dysfunction

Overlap in oncogenic and pro-inflammatory pathways associated with areca nut and nicotine exposure: 《Cancer Pathogenesis and Therapy》2024年第3期187-194,共8页Krati Garg Anuj Kumar Vidisha Kizhakkethil Pramod Kumar Shalini Singh; supported by intramural funding from the National Institute of Cancer Prevention and Research,Indian Council of Medical Research(No.NICPR/Anuj/intramural/2021/1).; Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of cancer.Unlike other psychoactive substances,such as nicotine,the mechanisms...; 关键词：Cancer Areca nut NICOTINE INTERACTOME Cell signaling

Health outcomes of electronic cigarettes: 《Chinese Medical Journal》2024年第16期1903-1911,共9页Xinmeng Li Lingzhi Yuan Fen Wang; supported by grants from the National Natural Science Foundation of China(No.82270594);the Scientific Research Project of Hunan Provincial Health Commission(No.202103032097).; The usage of electronic cigarettes(e-cigarettes)sparked an outbreak of unidentified vaping-related lung disease in the US during late 2019.With e-cigarettes becoming more and more popular,smokers have more options oth...; 关键词：Electronic cigarettes Electronic nicotine delivery system Smoking cessation Health promotion Tobacco harm reduction SMOKER

Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway: 《Asian Pacific Journal of Tropical Biomedicine》2024年第8期341-349,共9页Nora A.Elsayed Fatma SM Moawed Esraa SA Ahmed Ahmed Hammad Omayma AR Abo-Zaid; Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver damage.Methods:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and ...; 关键词：FLAVONE NICOTINE Liver NRF2 HO-1 NF-κB

When smoke meets gut:deciphering the interactions between tobacco smoking and gut microbiota in disease development被引量：2: 《Science China(Life Sciences)》2024年第5期854-864,共11页Bo Chen Guangyi Zeng Lulu Sun Changtao Jiang; supported by the National Natural Science Foundation of China (31925021, 82130022);the National Key Research and Development Program of China (2018YFA0800700, 2022YFA0806403)。; Tobacco smoking is a prevalent and detrimental habit practiced worldwide,increasing the risk of various diseases,including chronic obstructive pulmonary disease(COPD),cardiovascular disease,liver disease,and cancer.Al...; 关键词：tobacco smoking gut microbiota dysbiosis NICOTINE smoking cessation

Nicotine up-regulates SLC7A5 expression depending on TRIM29 in non-small cell lung cancer: 《Genes & Diseases》2024年第2期582-584,共3页Dahua Liu Haolin Ren Guimin Wen Pu Xia; supported by the National Natural Scientific Foundation of China(No.81972784);the“Double First-Class”Disciplinary Construction Project of Jinzhou Medical University(Liaoning,China).; Non-small cell lung cancer(NSCLC)is a malignant tumor that poses a serious threat to human health.Adenocarcinoma(LUAD)and squamous cell carcinoma(LUSC)are two common types of NSCLC.They originate from glandular and sq...; 关键词：LUNG CANCER NSCLC

Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis: 《Signal Transduction and Targeted Therapy》2024年第4期1690-1705,共16页Yan Fu Keyu Shen Hao Wang Shun Wang Xufeng Wang Le Zhu Yan Zheng Tiantian Zou Hongfei Ci Qiongzhu Dong Lun-Xiu Qin; supported by National Key Research and Development Program of China (2023YFC2413200/2023YFC2413201);National Nature Science Foundation of China (NSFC) (No.91959203 and No.81930074);the grant provided by National Research Center for Translational Medicine at Shanghai,Rujin Hospital,Shanghai Jiao Tong University School of Medicine (Shanghai,China) (NRCTM (SH)-2023-03).; Neurotransmitter-initiated signaling pathway were reported to play an important role in regulating the malignant phenotype of tumor cells.Cancer cells could exhibit a"neural addiction"property and build up local nerve...; 关键词：GSK3Β METASTASIS ALPHA

Smoking associated metabolites from gut microbiota on health:Nicotine degradation brings hopes: 《EngMedicine》2024年第3期21-29,共9页Guangyi Zeng Wanwan Guo Bo Chen Yanli Pang Lulu Sun; supported by the National Natural Science Foundation of China(nos.82370848,82371643,and HY2022-7);the special fund of the National Clinical Key Specialty Construction Program,China(2023).; Cigarette smoking accelerates metabolic disorders and is highly addictive,posing challenges for cessation.Recent studies have proposed that nicotine accumulates in the intestines of smokers,where it interacts with gut...; 关键词：Microbial based therapies Gut microbiota Smoking-related diseases Nicotine metabolism Microbial metabolites

Variability and Correlation in Biomarkers of Exposure from Two Randomized Controlled Studies of JUUL Electronic Nicotine Delivery Systems: 《Open Journal of Preventive Medicine》2023年第10期271-284,共14页Qiwei Liang Lonnie Rimmer Nick Goldenson Ryan Black; The data included in this analysis were from two clinical studies (Study A and Study B), which evaluated JUUL electronic nicotine delivery systems (ENDS) against combustible cigarettes. In both studies, biomarkers of ...; 关键词：Biomarkers VARIABILITY CORRELATION Electronic Nicotine Delivery System

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