Smoking associated metabolites from gut microbiota on health:Nicotine degradation brings hopes  

作　　者：Guangyi Zeng Wanwan Guo Bo Chen Yanli Pang Lulu Sun 

机构地区：[1]State Key Laboratory of Female Fertility Promotion,Department of Endocrinology and Metabolism,Peking University Third Hospital,Beijing 100191,China [2]Institute of Advanced Clinical Medicine,Peking University,Beijing 100191,China [3]State Key Laboratory of Female Fertility Promotion,Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing,China [4]Centre for Lipid Research and Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education),Department of Infectious Diseases,Institute for Viral Hepatitis,The Second Affiliated Hospital,Chongqing Medical University,400016,Chongqing,China

出　　处：《EngMedicine》2024年第3期21-29,共9页医工交叉（英文）

基　　金：supported by the National Natural Science Foundation of China(nos.82370848,82371643,and HY2022-7);the special fund of the National Clinical Key Specialty Construction Program,China(2023).

摘　　要：Cigarette smoking accelerates metabolic disorders and is highly addictive,posing challenges for cessation.Recent studies have proposed that nicotine accumulates in the intestines of smokers,where it interacts with gut microbiota and disrupts systemic metabolism.After smoking,significant alterations in the gut microbiota affect the synthesis of numerous metabolites that are crucial for the development and progression of metabolic disorders.Gut microbiota-mediated nicotine degradation has emerged as a promising therapeutic approach for smoking-related metabolic disorders associated with smoking.Herein,we explore the impact of smoking on the composition and function of the gut microbiota,emphasizing the potential link between smoking-related metabolic disorders and dysbiosis of the gut microbiota and microbial metabolites.Additionally,we discuss the in vivo distribution and metabolism of nicotine along with potential strategies for treating smoking-related metabolic disorders through the microbial degradation of nicotine.

关 键 词：Microbial based therapies Gut microbiota Smoking-related diseases Nicotine metabolism Microbial metabolites 

分 类 号：R57[医药卫生—消化系统]