Flavone improves liver damage in nicotine-exposed rats via the Nrf2/HO-1 pathway  

作　　者：Nora A.Elsayed Fatma SM Moawed Esraa SA Ahmed Ahmed Hammad Omayma AR Abo-Zaid 

机构地区：[1]Biochemistry and Molecular Biology Department,Faculty of Vet.Med.Benha University,Benha city,Egypt [2]Health Radiation Research,National Center for Radiation Research and Technology,Egyptian Atomic Energy Authority,Cairo,Egypt [3]Radiation Biology Department,National Center for Radiation Research and Technology,Egyptian Atomic Energy Authority,Cairo,Egypt

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第8期341-349,共9页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To assess the hepatoprotective effects of flavone on nicotine-induced liver damage.Methods:Thirty-six rats were allocated into six groups:the control group,the nicotine group,the flavone alone groups(10 and 25 mg/kg/body weight),and the nicotine groups treated with flavone(10 and 25 mg/kg/body weight).Liver function,oxidative stress,Nrf2 pathway(HO-1,Nrf2,and Keap-1),and inflammatory markers(IL-17,TNF-α,and NF-κB)were evaluated.Additionally,a histopathological examination of liver tissues was performed.Results:Nicotine increased liver damage,inflammation,and oxidative stress.However,flavone suppressed nicotine-induced liver enzymes,oxidative stress,and inflammation,as manifested by increased antioxidants and decreased malondialdehyde level,liver enzymatic activities,and inflammatory markers.Flavone(10 and 25 mg/kg/body weight)also reduced the level of Keap-1 and increased HO-1 and Nrf2 levels in the liver of nicotine-exposed rats.Conclusions:Flavone has hepatoprotective properties and may slow the progression of liver injury by reducing oxidative stress,liver enzymes,and inflammation possibly via the Nrf2 pathway.

关 键 词：FLAVONE NICOTINE Liver NRF2 HO-1 NF-κB 

分 类 号：R285[医药卫生—中药学] R575[医药卫生—中医学]