云南高校图书馆联盟文献共享服务平台- ALPHA

ALPHA: 作品数：1723被引量：2106H指数：18; 导出分析报告; 相关领域：自动化与计算机技术医药卫生更多>>; 相关作者：唐世浩高炳张丽果杜慧敏周明更多>>; 相关机构：中国科学院北京大学武汉大学上海交通大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease: 《Neural Regeneration Research》2025年第10期2998-3012,共15页Yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang; supported by the Science and Technology(S&T)Program of Hebei Province,No.22377798D(to YZ).; Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease progression.The proteins,DNA,mRNA,and lipids carried by exosomes reflect...; 关键词：biomarker diagnosis EXOSOMES N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Hereditary alpha tryptasemia and clinical implications: 《World Journal of Clinical Cases》2025年第21期6-15,共10页Ece TüsüzÖnata ÖnerÖzdemir Süreyya Savaşan; Hereditary alpha tryptasemia was first described in 2016 and is the most common(up to 72%)cause of elevated serum basal tryptase(TPS).The clinical presentation of this condition,which is caused by copy number gains in...; 关键词：Tryptasemia Autosomal dominant Hereditary alpha tryptasemia Mast cell Tyrosine kinase protein

“没有一克重量用于户外生存”德国波尔武力H3 ALPHA ONE TACTICAL重型战术折刀: 《轻兵器》2025年第5期72-75,共4页梅卡瓦; “没有一磅重量用于对陆攻击”,很多人提到经典的F-15战斗机都会想起这句脍炙人口的广告词。而德国波尔武力公司的H3 ALPHA ONE TACTICAL重型战术折刀同样有着“没有一克重量用于户外生存”的特殊评价,其设计就是为战斗做准备。; 关键词：H3 ALPHA ONE TACTICAL 户外生存德国波尔武力战术折刀

基于Alpha Shapes轮廓点云识别算法的洞室表面形变区域提取方法: 《南京信息工程大学学报》2025年第2期181-190,共10页张雨婷郑德华李思远; 钱投科创项目(QT202208A001)。; 针对三维激光扫描密集点云提取洞室表面变形信息的问题,本文提出一种基于改进的Alpha Shapes算法识别洞室轮廓点云和多尺度模型到模型的点云比对(Multiscale Model-to-Model Cloud Comparison,M3C2)的洞室表面变形监测方法.首先对获取...; 关键词：洞室变形监测轮廓点云识别 Alpha Shapes算法 M3C2算法

Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinoma: 《World Journal of Gastrointestinal Oncology》2025年第3期322-333,共12页Xia Chen Hai-Yan Liu Wu-Bi Zhou Li-Li Zhang Jian Huang Da-Wei Bao; BACKGROUND Esophageal squamous-cell carcinoma(ESCC)is a highly aggressive cancer,predominantly affecting populations in Eastern Asia and parts of Africa.Its pathogenesis is influenced by both genetic and environmental...; 关键词：Esophageal squamous-cell carcinoma Hypoxia-inducible factor 1-alpha Lactate dehydrogenase A Metabolic reprogramming Therapeutic target

Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer: 《World Journal of Gastroenterology》2025年第11期153-163,共11页Ze-Song Meng Ji-Tao Hu Hao Wu Bao-Kun Li; Supported by the Medical Science Research Project Plan of the Hebei Provincial Health Commission,No.20210027.; BACKGROUND The upregulation of serpin family B member 5(SERPINB5)has been linked to the progression of rectal cancer.However,the specific roles and underlying mechanisms of SERPINB5 in rectal cancer are not fully unde...; 关键词：Rectal cancer Serpin family B member 5 Heat shock protein 90 alpha class A member 1 PROLIFERATION INVASION

Characteristics and therapeutic strategies for familial gastrointestinal stromal tumors: 《World Journal of Gastrointestinal Oncology》2025年第3期13-18,共6页Yuan Liu Xiao-Feng Li; National Natural Science Foundation of China,No.82370569;Basic and Applied Basic Research Foundation of Guangdong Province,No.2022A1515012647;the Key Program for Science and Technology Projects of Social Development in Zhuhai,No.2220004000249(to Li XF).; This editorial discusses Wang et al's article on familial gastrointestinal stromal tumors(GISTs).We read with great interest this article concerning the diagnosis,treatment,and post-treatment management of patients wi...; 关键词：Gastrointestinal stromal tumors KIT mutation Platelet-derived growth factor receptor alpha mutation Wild-type gastrointestinal stromal tumor Tyrosine kinase inhibitors Familial gastrointestinal stromal tumor syndromes Molecular characteristics Targeted therapy

GNAO1调控上皮-间质转化对脑胶质瘤不良预后的影响: 《浙江医学》2025年第5期462-468,共7页刘雪吴卉吴琼姚庆华; 浙江省自然科学基金资助项目(LQ23H160008、LZ20H290001)。; 目的探讨G蛋白亚基Alpha O1(GNAO1)在脑胶质瘤组织中的表达及其调控脑胶质瘤细胞生物学行为的分子机制和对患者预后的影响。方法从癌症基因组图谱(TCGA)数据库和基因型-组织表达(GTEx)数据库下载706例脑胶质瘤患者和1152例正常脑组织的G...; 关键词：脑胶质瘤 G蛋白亚基Alpha O1 上皮-间质转化迁移侵袭

Validation of Anti-Hair Loss Tonic Containing 1.0%Arctium Lappa Root Extract for Chinese Consumers: 《China Detergent & Cosmetics》2025年第1期52-57,共6页Zeng Haifeng Lin Xianting Yang Jianzhong Iwano Hideki Sawaki Shigetoyo; A hair tonic containing 1.0%Arctium lappa root extract(ALRE)was evaluated for its efficacy and tolerability in Chinese consumers.ALRE was selected based on its ability to promote Collagen Type XVII Alpha 1(COL17A1)syn...; 关键词：Arctium lappa root extract hair loss hair outer root sheath cells Collagen Type XVII Alpha 1(COL17A1) clinical efficacy Chinese consumers

Mechanism of Hypoxia-Inducible Factor 1 Alpha Regulation of Apoptosis in Human Spermatozoa: 《Advances in Reproductive Sciences》2025年第1期49-62,共14页Xinge Liu Linfeng Mo Yinjia Zhang Liangzhao Liu Yan Zhang Yonghua He Mingxue Zhang Lishan Tang; Objective: To investigate the specific mechanism of hypoxia-inducible factor 1 alpha (HIF-1α) in the regulation of human sperm apoptosis, and to provide a new theoretical reference and scientific basis for the diagno...; 关键词：Hypoxia Inducible Factor-1α APOPTOSIS Sperm Motility ASTHENOSPERMIA

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