DIACEREIN

作品数：5被引量：3H指数：1
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Combination of anti-inflammatory therapy and RNA interference by light-inducible hybrid nanomedicine for osteoarthritis treatment
《Acta Pharmaceutica Sinica B》2024年第11期5008-5025,共18页Li Qiao Zhiyao Li Bowen Li Fu Zhang Zhuo Yao Chongzhi Wu Honglin Tang Qi Pan Peihua Shi Yuan Ping 
National Natural Science Foundation of China(82172458,82371589,82073779,and 32000992);Natural Science Foundation of Zhejiang Province(Distinguished Young Scholar Program,No.LR21H300002,China).
Osteoarthritis(OA)is a type of highly prevalent heterogeneous degenerative disease that leads to joint pain,deformity,the destruction of articular cartilage,and eventual disability.The current treatment strategies for...
关键词：OSTEOARTHRITIS Gold nanocages Poly(β-amino-ester) DIACEREIN Pain relief Photothermal effect Phase-change material Combinational therapy 
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway
《Chinese Journal of Natural Medicines》2024年第4期318-328,共11页YE Qiaobei ZHU Yu SHI Meng LV Linxi GONG Yuyan ZHANG Luyao YANG Lehe ZHAO Haiyang ZHAO Chengguang XU Huanhai 
supported by the National Natural Science Foundation of China(Nos.82173856 and 82203322);the Natural Science Foundation of Zhejiang Province(Nos.LY21H300005 and LGF22H030014);Wenzhou Municipal Science and Technology Bureau(Nos.ZY2020025 and H20210009);the Science and Technology Innovation Activity Plan for College Students of Zhejiang Province(No.2019R413012)。
Double cortin-like kinase 1(DCLK1)exhibits high expression levels across various cancers,notably in human colorectal cancer(CRC).Diacerein,a clinically approved interleukin(IL)-1βinhibitor for osteoarthritis treatmen...
关键词：DCLK1 DIACEREIN RHEIN STAT3 Colorectal cancer 
Diacerein treatment prevents colitis-associated cancer in mice被引量：1
《World Journal of Clinical Oncology》2020年第9期732-746,共15页Daiane S M Paulino Maria Carolina S Mendes Juliana A Camargo Sandra R Brambilla Tanila Wood Dos Santos Marcelo L Ribeiro JoséBarreto Campello Carvalheira 
Supported by the São Paulo Research Foundation,No.07607-8/2013;and the National Research Council,No.150127/2016-2 and No.306821/2010-9.
BACKGROUND Inflammation is a well-established enabling factor for cancer development and provides a framework for the high prevalence of colon cancer in inflammatory bowel disease.In accordance,chronic inflammation ha...
关键词：Colon cancer Cancer stem cell CHEMOPREVENTION 
Diacerein protects against iodoacetate-induced osteoarthritis in the femorotibial joints of rats被引量：1
《The Journal of Biomedical Research》2015年第5期405-413,共9页Achint Jain Royana Singh Saurabh Singh Sanjay Singh 
University Grant Commission,New Delhi for the financial support in the form of Senior Research Fellowship;Dr.Reddy's Laboratories Ltd.(Hyderabad, India) for providing diacerein as gift sample
The present study was undertaken to investigate the effect of diacerein on the histopathology of articular cartilage and subchondral bone of the femorotibial joint in rats. Osteoartbritis was induced in rats after sin...
关键词：DIACEREIN OSTEOARTHRITIS articular cartilage chondroitin sulfate HISTOPATHOLOGY 
EVALUATION OF EFFICACY AND SAFETY OF DIACEREIN IN KNEE OSTEOARTHRITIS IN CHINESE PATIENTS被引量：1
《Chinese Medical Sciences Journal》2006年第2期75-80,共6页Wen-jie Zheng Fu-lin Tang Jun Li Feng-chun Zhang Zhan-guo Li Yin Su Dong-hai Wu Li Ma Hui-qiong Zhou Feng Huang Jiang-lin Zhang Dong-feng Liang Yi-xiong Zhou Hui Xu 
Objective To evaluate the efficacy and safety of diacerein in patients with knee osteoarthritis (OA). Methods A total of 223 patients satisfying the American College of Rheumatology criteria for knee OA were chosen fo...
关键词：OSTEOARTHRITIS drug evaluation DIACEREIN diclofenac sodium 
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