云南高校图书馆联盟文献共享服务平台- RHEIN

RHEIN: 作品数：50被引量：124H指数：6; 导出分析报告; 相关作者：高萌殷志琦王杨郭美姿李孝生更多>>; 相关机构：中南大学南京中医药大学中国药科大学江苏省中医药研究院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家中医药管理局中医药科学技术研究专项更多>>

Palindrome-mediated DNA nanotubes with cell-specific aptamers to improve targeted antitumor effects and reduce toxicity on non-small cell lung cancer: 《Science China(Life Sciences)》2025年第2期454-466,共13页Cheng Zheng Lanlan Song Chang Yu Lingye Zhu Jing Zhang Ning Wang Mengchu Liu Shini Li Liangxing Wang Zhifa Shen Xiaoying Huang; the support from the First Affiliated Hospital of Wenzhou Medical University Medical Research Center。; Chemotherapy is regarded as a widely used and effective treatment strategy for lung cancer,although most conventional chemotherapeutics cause severe toxic side-effects due to their indiscriminate attacks on both cance...; 关键词：DNA nanotube self-assembly RHEIN targeted drug delivery cancer therapy

Treatment of constipation with Aloe and its compatibility prescriptions: 《Chinese Herbal Medicines》2024年第4期561-571,共11页Xianhui Shen Liping Gong Rongrong Li Nana Huang Huijie Zhang Siyi Chen Ying Liu Rong Sun; supported by National Key Research and Development Program (No. 2022YFC3502100, 2022YFC3502102-05);Joint Fund of Natural Fund of Shandong Province (No. ZR2021LZY036);Lunan Hope Pharmaceutical Co., Ltd. (No. 1520019013)。; Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. Howev...; 关键词：ALOE ALOE-EMODIN clinical research gastrointestinal hormone RHEIN Shouhui Tongbian Capsules

Rhein-based Pickering emulsion for hepatocellular carcinoma:Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization: 《Aggregate》2024年第4期319-338,共20页Xiaoliu Liang Hui Liu Hu Chen Xuqi Peng Zhenjie Li Minglei Teng Yisheng Peng Jiwei Li Linyu Ding Jingsong Mao Chengchao Chu Hongwei Cheng Gang Liu; Major State Basic Research Development Program of China,Grant/Award Number:2023YFB3810000;National Natural Science Foundation of China,Grant/Award Numbers:U22A20333,81925019,U1705281,82202330;Fundamental Research Funds for the Central Universities,Grant/Award Numbers:20720190088,20720200019;Science Foundation of Fujian Province,Grant/Award Number:2020Y4003;Program for New Century Excellent Talents in University,China,Grant/Award Number:NCET-13-0502。; The efficacy of transarterial chemoembolization(TACE)has been limited by insufficient embolization and a high incidence of tumor recurrence.Herein,we iden-tified that aberrant metabolic reprogramming and immunosuppres...; 关键词：GLYCOLYSIS hepatocellular carcinoma immunoembolization Pickering emulsion transarterial chemoem-bolization

Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway: 《Chinese Journal of Natural Medicines》2024年第4期318-328,共11页YE Qiaobei ZHU Yu SHI Meng LV Linxi GONG Yuyan ZHANG Luyao YANG Lehe ZHAO Haiyang ZHAO Chengguang XU Huanhai; supported by the National Natural Science Foundation of China(Nos.82173856 and 82203322);the Natural Science Foundation of Zhejiang Province(Nos.LY21H300005 and LGF22H030014);Wenzhou Municipal Science and Technology Bureau(Nos.ZY2020025 and H20210009);the Science and Technology Innovation Activity Plan for College Students of Zhejiang Province(No.2019R413012)。; Double cortin-like kinase 1(DCLK1)exhibits high expression levels across various cancers,notably in human colorectal cancer(CRC).Diacerein,a clinically approved interleukin(IL)-1βinhibitor for osteoarthritis treatmen...; 关键词：DCLK1 DIACEREIN RHEIN STAT3 Colorectal cancer

Potential Medicinal Value of Rhein for Diabetic Kidney Disease被引量：3: 《Chinese Journal of Integrative Medicine》2023年第10期951-960,共10页MAO Xi XU Ding-qiao YUE Shi-jun FU Rui-jia ZHANG Sai TANG Yu-ping; the National Key R&D Program of China(No.2019YFC1711000);Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019-YL10)。; Diabetic kidney disease(DKD)is the primary cause of mortality among diabetic patients.With the increasing prevalence of diabetes,it has become a major concern around the world.The therapeutic effect of clinical use of...; 关键词：RHEIN diabetic kidney disease rhein derivatives TOXICITY BIOAVAILABILITY

The protective effect and mechanism of rhein on diabetic cardiomyopathy by regulating Sirt1/PGC-1α pathway: 《Journal of Hainan Medical University》2023年第19期8-8,共1页WANG Tian-tian WANG Wei YANG Cui-hua LU Bin; National Natural Science Foundation Project (No.81873174)。; Objective:To explore the protective effects of rhein on cardiomyocyte injury in DCM and its possible mecha-nism.Methods:The diabetic model was induced by intraperitoneal injection with streptozotocin and high-fat diet...; 关键词：RHEIN Diabetic cardiomyopathy SIRT1 PGC‐1α

Advanced Oxidation Protein Products Regulate the Pharmacokinetics of Aloe-emodin,Emodin,Rhein,and Chrysophanol in Chronic Kidney Disease Rats: 《Clinical Complementary Medicine and Pharmacology》2023年第3期8-18,共11页Tianrong Xun Xiaokang Wang Jingqian Zhao Zhufen Lin Haixing Feng Liqian Mo Xixiao Yang; supported by Guangdong Science and Technology Program(No.2015B020211006);the Technology Project of Guangzhou City in China(No.201604020137);Shenzhen Foundation of Science and Technology(No.JCYJ20190814112205770);Research Foundation of Shenzhen Hospital of Southern Medical University(No.PY2021YM03);the Project of Traditional Chinese Medicine Bureau of Guangdong Province(No.20221273).; Background:As accelerators and products of the progression of chronic kidney disease(CKD),advanced oxidation protein products(AOPPs)affect the function of the liver.Huang Gan granules(HGGs)are commonly used to prevent...; 关键词：Advanced oxidation protein products(AOPPs) Chronic kidney disease(CKD) Huang Gan granules(HGGs) ALOE-EMODIN EMODIN RHEIN CHRYSOPHANOL

An innovative rhein-matrine cocrystal: Synthesis, characterization,formation mechanism and pharmacokinetic study被引量：1: 《Chinese Chemical Letters》2023年第2期546-549,共4页Hongjuan Wang Dezhi Yang Wen Zhang Junke Song Ningbo Gong Mingchao Yu Shiying Yang Baoxi Zhang Qiwen Liu Guanhua Du Yang Lu; supported by Drug Innovation Major Project (Nos. 2018ZX09711001–001–015, 2018ZX09711001–003– 022);CAMS Innovation Fund for Medical Sciences (No. 2016I2M-3–007)。; Rhein(Rhe), an anthraquinone derivative, exhibits excellent anti-inflammatory effects and other pharmacological activities, but its clinical application remains limited due to poor solubility. The present work aims at...; 关键词：RHEIN MATRINE COCRYSTAL Poor solubility Molecular surface electrostatic potential

Nano Calcium-Deficient Hydroxyapatite/O-carboxymethyl Chitosan-CaCl_(2) Microspheres Loadedwith RheinforBone Defect Repair被引量：1: 《Journal of Bionic Engineering》2022年第4期1087-1099,共13页Zhenzhen Tian Yuanyuan Guo Xiuying Yang Kebing Guo Jingou Ji Shilei Hao; Glutaraldehyde(GA),the most widely used crosslinking agent for biomaterials,is cytotoxic.CaCl_(2) is of particular interest due to its non-toxic nature.Rhein can chelate Ca^(2+)and promote bone growth.Here we reported...; 关键词：Nano calcium-deficient hydroxyapatite O-carboxymethyl chitosan RHEIN MICROSPHERES Bone repair

Structural landscape on a series of rhein:Berberine cocrystal salt solvates:The formation,dissolution elucidation from experimental and theoretical investigations: 《Chinese Chemical Letters》2022年第6期3207-3211,共5页Dezhi Yang Hongjuan Wang Qiwen Liu Penghui Yuan Ting Chen Li Zhang Shiying Yang Zhengzheng Zhou Yang Lu Guanhua Du; the Drug Innovation Major Project(No.2018ZX09711001-001-015);the CAMS Innovation Fund for Medical Sciences(No.2020-I2M-1-003)。; The specific crystalline form of a compound remarkably affects its physicochemical properties.Therefore,a detailed analysis of the structural features and intermolecular interactions of a multi-component crystal is fe...; 关键词：COCRYSTAL RHEIN BERBERINE Theoretical computation Energy decomposition analysis SOLUBILITY

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