CHRYSOPHANOL

作品数：16被引量：37H指数：3
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相关领域：医药卫生更多>>
相关作者：李利平马丽刘乐贺葵邦周嘉裕更多>>
相关机构：西南交通大学河北医科大学第二医院更多>>
相关期刊：《Chinese Herbal Medicines》《Science China Chemistry》《China Medical Abstracts(Internal Medicine)》《Current Medical Science》更多>>
相关基金：国家自然科学基金高等学校学科创新引智计划河北省自然科学基金更多>>
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Inhibition of human cytochrome CYP1B1 by anthraquinone compounds,chrysophanol and physcion
《黑龙江大学自然科学学报》2024年第4期427-433,共7页JIA Liwei ZHOU Lei WANG Zhenyue WANG Qianbo LIU Xiaoyan MENG Xin 
Supported by the Heilongjiang Administration of Traditional Chinese Medicine(ZHY2020-078);the Education Department of Heilongjiang Province(SJGY20210830)。
The in vitro inhibitory effects of chrysophanol and physcion on CYP1B1 were explored,utilizing ethoxyresorufin as the substrate.The inhibition kinetics of CYP1B1 by these compounds were assessed with escalating doses ...
关键词：CYP1B1 CHRYSOPHANOL PHYSCION anthraquinone derivative enzyme inhibitor 
Chrysophanol regulates AMPK/mTOR autophagy signal pathway to improve cognitive function in copper-laden rats with Wilson disease
《China Medical Abstracts(Internal Medicine)》2023年第3期137-138,共2页张笑颜 
Objective To study the neuroprotective effect of chrysophanol(CHR)on copper-laden rats with Wilson disease(WD),and explore its possible mechanism.Methods SD rats were randomly divided into 4 groups:control group(Contr...
关键词：mechanism RATS protective 
Advanced Oxidation Protein Products Regulate the Pharmacokinetics of Aloe-emodin,Emodin,Rhein,and Chrysophanol in Chronic Kidney Disease Rats
《Clinical Complementary Medicine and Pharmacology》2023年第3期8-18,共11页Tianrong Xun Xiaokang Wang Jingqian Zhao Zhufen Lin Haixing Feng Liqian Mo Xixiao Yang 
supported by Guangdong Science and Technology Program(No.2015B020211006);the Technology Project of Guangzhou City in China(No.201604020137);Shenzhen Foundation of Science and Technology(No.JCYJ20190814112205770);Research Foundation of Shenzhen Hospital of Southern Medical University(No.PY2021YM03);the Project of Traditional Chinese Medicine Bureau of Guangdong Province(No.20221273).
Background:As accelerators and products of the progression of chronic kidney disease(CKD),advanced oxidation protein products(AOPPs)affect the function of the liver.Huang Gan granules(HGGs)are commonly used to prevent...
关键词：Advanced oxidation protein products(AOPPs) Chronic kidney disease(CKD) Huang Gan granules(HGGs) ALOE-EMODIN EMODIN RHEIN CHRYSOPHANOL 
The mechanism of Chuanxiong Rhizoma on glaucomatous optic nerve injury based on network pharmacology and molecular docking
《TMR Modern Herbal Medicine》2023年第2期18-30,共13页An-Qi Yuan Bing-Yu Wang Lin-Jing Peng Hong-Yan Du 
National Natural Science Foundation of China(No.81704123);Science and Technology Program of Guangzhou(No.2023A03J0774).
Based on network pharmacology,this study predicted the potential molecular mechanism and related pathways of the protective effect of traditional Chuanxiong Rhizoma,a traditional Chinese herb,on glaucomatous optic ner...
关键词：Chuanxiong Rhizoma GLAUCOMA optic nerve damage network pharmacology molecular docking CHRYSOPHANOL 
Chrysophanol inhibits the progression of gastric cancer by activating nod-like receptor protein-3
《BIOCELL》2023年第1期175-186,共12页BINFEN HOU LI ZHAO TIANHAO ZHAO MINGMING YANG WANWAN ZHU XIAODONG CHEN XIQUAN KE ZHENZENG MA LIN GU MENG WANG MIN DENG 
This study was supported by the Natural Science Research Project of Anhui Province,Grant/Award No.[2008085MH282];Graduate Research Innovation Project of Bengbu Medical College,Grant/Award No.[Byycx20022];Key Science and Technology Project of Anhui Province Fund,Grant/Award No.[201904a07020022];2020 Outstanding University Talents Support Project,Grant/Award No.[gxyq2020023].
Aim:Gastric cancer(GC)is one of the most common malignant tumors.Chrysophanol has been reported to possess antitumor effects on a variety of cancers;however,its role in GC remains unclear.This study aimed to investiga...
关键词：CHRYSOPHANOL Gastric cancer NLRP3 inflammasome CASPASE-1 PYROPTOSIS 
Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage被引量：11
《Current Medical Science》2022年第2期249-266,共18页Kuldeep Singh JADAUN Sidharth MEHAN Aarti SHARMA Ehraz Mehmood SIDDIQUI Sumit KUMAR NaifALSUHAYMI 
The authors express their gratitude to Chairman,Mr.Parveen Garg and Director,Dr.G.D.Gupta,ISF College of Pharmacy,Moga(Punjab),India,for their great support.
Objective Intracerebral hemorrhage(ICH)refers to predominant,sporadic,and non-traumatic bleeding in the brain parenchyma.The PI3K/AKT/mTOR signaling pathway is an important signal transduction pathway regulated by enz...
关键词：intracerebral hemorrhage autologous blood PI3K/AKT/MTOR HEMATOMA CHRYSOPHANOL apoptosis NEUROTRANSMITTER NEUROINFLAMMATION 
Chrysophanol localizes in mitochondria to promote cell death through upregulation of mitochondrial cyclophilin D in HepG2 cells被引量：2
《Chinese Herbal Medicines》2021年第2期221-227,共7页Yu Xie Ling Zhang Yuan-yuan Li Dian He Li-fang Zheng 
supported by the Fundamental Research Funds for the Central Universities (Grant No.lzujbky-2018-131);the National Natural Sciences Foundation of China (Grant No.21302079)。
Objective:Chrysophanol(Chry) displays potent anticancer activity in human cancer cells and animal models,but the cellular targets of Chry have not been fully defined.Herein,we speculated whether mitochondria were a ta...
关键词：CHRYSOPHANOL combination therapy MITOCHONDRIA mitochondrial permeability transition pore MTDNA 
Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation被引量：9
《Acta Pharmaceutica Sinica B》2019年第4期782-793,共12页Jing Lu Jingyan Li Yuehuai Hu Zhen Guo Duanping Sun Panxia Wang Kaiteng Guo Dayue Darrel Duan Si Gao Jianmin Jiang Junjian Wang Peiqing Liu 
supported by grants from the 111 Project(No.B16047,China);National Natural Science Foundation of China(81473205,81673433,81803521,and 81872860);Major Project of Platform Construction Education Department of Guangdong Province(No.2014GKPT002,China);Special Program for Applied Science and Technology of Guangdong Province(Nos.2015B020232009,2014B020210003 and 2013B090700010,China);National Engineering and Technology Research Center for New drug Druggability Evaluation(Seed Program of Guangdong Province,2017B090903004,China);Guangzhou Science and Technology Program Project(No.201604020121,China);Medical Scientific Research Foundation of Guangdong Province(No.A2018078,China)
The clinical application of doxorubicin(DOX) in cancer chemotherapy is limited by its lifethreatening cardiotoxic effects. Chrysophanol(CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., i...
关键词：CHRYSOPHANOL DOXORUBICIN PARylation CARDIOTOXICITY Apoptosis MITOCHONDRIA 
Characterization and Deer-Repellent Property of Chrysophanol and Emodin from Sicklepod Weed
《American Journal of Plant Sciences》2018年第2期266-280,共15页Ziming Yue Te-Ming Tseng Marcus Lashley 
Deer, particularly white-tailed deer (Odocoileus virginianus), damage row crops such as soybean (Glycine max L.) and are a perceived problem in the continental US. Currently, the only widely used technique to control ...
关键词：Sicklepod WEED Anti-Herbivore Deer-Repellant Anthraquinone Derivative Soybean DEER Browsing 
Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice被引量：8
《Neural Regeneration Research》2014年第9期924-930,共7页Ji Zhang Chunlin Yan Shu Wang Yong Hou Guiping Xue Li Zhang 
financially supported by the Science and Technology Commission Foundation of Zhangjiakou City,No.1021098D;the Medical Scientific Research Project of Health Bureau of Hebei Province,No.20100144;the Natural Science Foundation of Hebei Province,No.H2012405016;the Innovative Talents Project of Hebei North University,No.CXRC1325;the Major Projects of Hebei North University,No.ZD201310
Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory d...
关键词：nerve regeneration traditional Chinese medicine CHRYSOPHANOL lead poisoning lead MALONDIALDEHYDE superoxide dismutase glutathione peroxidase neurons neonatal mice antioxidant learning and memory Morris water maze step-down test hippocampal neurons ULTRASTRUCTURE Medical Scientific Research Project of Health Bureau of Hebei Province neural regeneration 
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