PHYSCION

作品数：7被引量：26H指数：3
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相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Chinese Chemical Letters》《World Journal of Gastrointestinal Oncology》更多>>
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Inhibition of human cytochrome CYP1B1 by anthraquinone compounds,chrysophanol and physcion
《黑龙江大学自然科学学报》2024年第4期427-433,共7页JIA Liwei ZHOU Lei WANG Zhenyue WANG Qianbo LIU Xiaoyan MENG Xin 
Supported by the Heilongjiang Administration of Traditional Chinese Medicine(ZHY2020-078);the Education Department of Heilongjiang Province(SJGY20210830)。
The in vitro inhibitory effects of chrysophanol and physcion on CYP1B1 were explored,utilizing ethoxyresorufin as the substrate.The inhibition kinetics of CYP1B1 by these compounds were assessed with escalating doses ...
关键词：CYP1B1 CHRYSOPHANOL PHYSCION anthraquinone derivative enzyme inhibitor 
Physcion increases the sensitivity of hepatocellular carcinoma to sorafenib through miRNA-370/PIM1 axis-regulated glycolysis
《World Journal of Gastrointestinal Oncology》2023年第8期1400-1411,共12页Xiao-Ping Pan Bu-Ren Jiya Feng Wang Zhu Lan 
Supported by National Natural Science Foundation of China,No.81960782.
BACKGROUND Resistance to sorafenib has become a challenge in clinical treatment of hepatocellular carcinoma(HCC).Physcion is a common bioactive anthraquinone that has potential as an anticancer agent.AIM To study the ...
关键词：Hepatocellular carcinoma Sorafenib resistance PHYSCION GLYCOLYSIS PIM1 
In vivo and in vitro anti-sepsis effects of physcion 8-O-β- glu- copyranoside extracted from Rumexjaponicus被引量：2
《Chinese Journal of Natural Medicines》2017年第7期534-539,共6页FU Wei-Jun TANG Jian-Jun WANG Hui WEI Hong-Yun CAI Shu-Min ZENG Zhen-Hua CHEN Hui CHEN Zhong-Qing 
The present study was designed to investigate the anti-sepsis effects of physcion 8-O-β-glucopyranoside (POG) isolated from Rumex japonicas and explore its possible pharmacological mechanisms. POG was extracted from ...
关键词：Anti-sepsis TLR-4 TLR-2 PRO-INFLAMMATORY cytokines LPS 
Physclon, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma被引量：9
《Acta Pharmacologica Sinica》2016年第12期1623-1640,共18页Ming-jie PANG Zhun YANG Xing-lin ZHANG Zhao-fang LIU Jun FAN Hong-ying ZHANG 
Aim： Physcion is a major bioactive ingredient in the traditional Chinese medicine Radix et Rhizoma Rhei, which has an anthraquinone chemical structure and exhibits a variety of pharmacological activities including la...
关键词：PHYSCION human nasopharyngeal carcinoma CNE2 cells apoptosis  autophagy SPL miR-27a 
Physc,on 8-O-β-glucopyranoside induces mitochondria-dependent apoptosis of human oral squamous cell carcinoma cells via suppressing survivin expression被引量：7
《Acta Pharmacologica Sinica》2016年第5期687-697,共11页Meng-dong LIU Shi-jiang XIONG Fei TAN Yi LIU 
Aim： A previous study has shown that physcion 8-O-β-glucopyranoside （PG） derived from Rumexjaponicus Houtt causes apoptosis and blocks cell cycle progression in human lung cancer cells. In the present study we inv...
关键词：physcion 8-O-β-glucopyranoside human oral squamous cell carcinoma mitochondria-dependent apoptosis SURVIVIN miR-21 PTEN Akt/GSK3β 
Physcmn inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2被引量：11
《Acta Pharmacologica Sinica》2016年第2期264-275,共12页Yan-tao HAN Xue-hong CHEN Hui GAO Jun-li YE Chun-bo WANG 
This work was supported by the National Natural Science Foundation of China （ No 81473384）.
Aim： Physcion, an anthraquinone derivative, exhibits hepatoprotective, anti-inflammatory, anti-microbial and anti-cancer activities. In this study we examined whether and how physcion inhibited metastatic potential o...
关键词：PHYSCION ANTHRAQUINONE human colorectal cancer cell line SW620 metastasis EMT process SOX2 ROS AMPK GSK3Β 
Thermal Characterization and Decomposition Kinetics of Free Anthraquinones from Rhubarb被引量：1
《Chinese Chemical Letters》2006年第5期699-702,共4页Li Ming ZHANG Xia LI Yu Jie DAI 
The thermal behaviour of aloe-emodin, chrysophanol and physcion and their kinetics have been investigated under non-isothermal conditions by means of differential thermal analysis （DTA） and thermogravimetry （TG）. ...
关键词：ALOE-EMODIN CHRYSOPHANOL PHYSCION thermogravimetry （TG） differential thermoanalysis （DTA） non-isothermal kinetics. 
何首乌毛状根诱导与Emodin及Physcion之成分分析
《作物、環境與生物資訊》林李昌(Li-Chang Lin) 李鎮宇(Chen-Yue Lee) 林昆彥(Kun-Yen Lin) 葉茂生(Mau-Shing Yeh) 蔡新聲(Hsin-Sheng Tsay) 
本试验之目的为建立何首乌毛状根转殖系统与毛状根转殖株的监定方法，并以emodin及physcion为指标成分，进行何首乌的市售品、栽培的块根及毛状根成分含量比较，以探讨利用毛状根培养方式生产植物二次代谢物之可行性。结果发现毛状根的...
关键词：蔥醌類化合物 毛狀根 何首烏 rol B基因 rol C基因 
生药“何首乌”中2,3,5,4'-tetrahydroxystilbene-2-O-glucoside、emodin及physcion的含量分析
《中醫藥雜誌》陳建志(Chien-Chih Chen) 石宜仁(Yi-Zen Shih) 黃鈺玲(Yu-Lin Huang) 歐潤芝(Jun-Chih Ou) 
For the identification of the crud drug Polygoni Multitlori Radix, the Standard of Crude Drugs of Japanese Pharmacopeia uses emodin as the indicative substance. Recently, 2,3,5,4'-Tetrahydroxystilbene-2-O-Glucosid...
关键词：何首鳥 
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