MATRINE

作品数：83被引量：532H指数：14
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相关领域：医药卫生更多>>
相关作者：张俊平阮丽萍周俭平王玲罗大力更多>>
相关机构：第二军医大学哈尔滨医科大学中国人民解放军南京军区南京总医院更多>>
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Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression
《World Journal of Gastrointestinal Oncology》2024年第12期4700-4715,共16页Yuan-Chen Zhou Qian-Qian Wang Ge-Yu-Jia Zhou Teng-Fei Yin Dong-Yan Zhao Xi-Zhen Sun Chang Tan Lei Zhou Shu-Kun Yao 
Supported by National Key Development Plan for Precision Medicine Research,No.2017YFC0910002.
BACKGROUND The 5-year survival rate of patients with colorectal cancer(CRC)in China is only 56.9%,highlighting the need for new therapeutic drugs.Previous studies have shown that matrine exhibits antitumor effects by ...
关键词：Colorectal cancer Proteomics Shank-associated RH domain interactor MATRINE APOPTOSIS 
Matrine-loaded self-adhesive swelling microneedle for inflammation regulation to improve eczema treatment被引量：1
《Marine Life Science & Technology》2024年第3期535-546,共12页Jiale Shen Jiarui Wang Meng Wu Yan Shi Minhyeock Lee Zhiguo Wang Ming Kong 
funded by Natural Science Founda-tion of Shandong Province(ZR2022MC033);Qingdao Science&Technology Benefiting People Project(24-1-8-smjk-11-nsh).
Eczema is a common chronic dermatological disease.Conventional treatments exhibit limited efficacy due to fast drug release resulting in short-term relief.Development of a new treatment strategy that enables sustained...
关键词：Self-adhesive swelling microneedle ECZEMA MATRINE Inflammation regulation 
Simultaneous Determination of Trace Matrine and Oxymatrine Pesticide Residues in Tea by Magnetic Solid-Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry
《Journal of Analysis and Testing》2024年第2期245-250,共6页Hongmei Liu Yang Li Yangjiayi Xiang Hao Cao Yan Li 
supported by funds provided by the National Natural Science Foundation of China(21974024 and 22274025)。
We developed a magnetic solid-phase extraction method using Fe_(3)O_(4)@polydopamine(Fe_(3)O_(4)@PDA)as adsorbents,coupled with liquid chromatography-tandem mass spectrometry(LC-MS/MS),for the enrichment and quantific...
关键词：ADSORBENT CHROMATOGRAPHY adsorption 
Matrine, a potential drug for the treatment of rheumatoid arthritis
《Rheumatology & Autoimmunity》2024年第1期11-19,共9页Yaping Peng Xinqiao Lian Yan Wang Xin Li 
Science and Technology Commission of Tongzhou District,Beijing Municipal(No.KJ2019CX001-05);Youth Scientific Research Incubation Program of Beijing Luhe Hospital,Capital Medical University(No.LHYY2023-JC209).
Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease with a multifaceted pathogenesis involving genetic,epigenetic,and environmental factors.It mainly targets the synovium,leading to synovitis and subs...
关键词：INFLAMMATION MATRINE mechanism rheumatoid arthritis signaling pathway TREATMENT 
Study on the mechanism of the anti-tumor effects of matrine via regulation of lipid metabolism mediated by SREBP signaling pathway
《Cancer Advances》2023年第12期1-5,共5页Fang-Hua Wu Fei Huang Yan Chen Kui Chen Chao Gong Shen-Zhou Huang Jiang-Yue Yu Ruo-Qin Zhao Pei-Wen Zhu Li-Qun Wang 
This work was supported by grants from the Natural Science Foundation of Fujian province(No.2020J011181).
Objective:To investigate the therapeutic effects of matrine on CT26 tumor-bearing mice and its effect on the sterol regulatory element binding protein(SREBP)signaling pathway.Methods:A CT26 tumor-bearing mouse model w...
关键词：MATRINE CT26 TUMOR lipid metabolism SREBP 
New polychlorinated bibenzyls from Rhododendron minutiflorum
《Natural Products and Bioprospecting》2023年第1期709-717,共9页Yang-Li Zhu Li Deng Yu Tang Xian-Zhe Fan Yang Han Mei Pan Li-Jun Zhang Hai-Bing Liao 
The Natural Science Foundation of China(32160109,31800294);the Natural Science Foundation of Guangxi Province of China(2018GXNSFBA138006,2019AC20231);Educational Department of Guangxi(2018KY0089);the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(CMEMR2017-A07,2020-A09);Joint cultivation base of biology and medicine graduate student between Guangxi Normal University and Guilin Pharma Company.
Five new polychlorinated bibenzyls(1-5)along with 3 known compounds(6-8)were isolated from the stems and leaves of Rhododendron minutiflorum.The chemical structures of all the isolates were determined by spectroscopic...
关键词：Rhododendron minutiflorum Polychlorinated bibenzyls MATRINE Insecticidal activity Diaphorina citri α-Glucosidase inhibitory activity ACARBOSE 
An innovative rhein-matrine cocrystal: Synthesis, characterization,formation mechanism and pharmacokinetic study被引量：1
《Chinese Chemical Letters》2023年第2期546-549,共4页Hongjuan Wang Dezhi Yang Wen Zhang Junke Song Ningbo Gong Mingchao Yu Shiying Yang Baoxi Zhang Qiwen Liu Guanhua Du Yang Lu 
supported by Drug Innovation Major Project (Nos. 2018ZX09711001–001–015, 2018ZX09711001–003– 022);CAMS Innovation Fund for Medical Sciences (No. 2016I2M-3–007)。
Rhein(Rhe), an anthraquinone derivative, exhibits excellent anti-inflammatory effects and other pharmacological activities, but its clinical application remains limited due to poor solubility. The present work aims at...
关键词：RHEIN MATRINE COCRYSTAL Poor solubility Molecular surface electrostatic potential 
Matrine, oxymatrine, and compound Kushen injection from the roots of Sophora flavescens: an overview of their anticancer activities被引量：1
《Journal of Chinese Pharmaceutical Sciences》2022年第5期321-333,共13页Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan 
In the present review,we updated current information on the chemistry,contents,and anticancer properties of matrine(MT),oxymatrine(OMT),and compound Kushen injection(CKI).The anticancer properties were focused on lung...
关键词：INJECTION INVASION ROOTS 
Structurally Diverse Matrine-Based Alkaloids with Anti-inflam-matory Effects from Sophora alopecuroides被引量：3
《Chinese Journal of Chemistry》2021年第12期3339-3346,共8页Ding Luo Neng-Hua Chen Wen-Zhi Wang Ji-Hui Zhang Can-Jie Li Xue-Fang Zhuo Zhen-Chao Tu Zhong-Nan Wu Chun-Lin Fan Hai-Peng Zhang Yao-Lan Li Guo-Cai Wang Yu-Bo Zhang 
This project was supported financially by grants from the National Natural Science Foundation of China(Nos.81803376,82074116,81973190);the Guangdong Basic and Applied Basic Research Foundation(No.2020B1515020033);the Natural Science Foundation of Guangdong Province(No.2018B030311020);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036);Guangdong Basic and Applied Basic Research Foundation-Regional Joint Fund(Youth Fund Project,No.2020A1515110415);Pearl River S&T Nova Program of Guangzhou(No.201906010069);We thank the High Performance Public Computing Service Platform of Jinan University for the help of theoretical ECD calculations.
A phytochemical investigation on the seeds of Sophora alopecuroides led to obtaining fourteen structurally diverse matrine-based alkaloids(1-14),including eight new ones(1,6,8-12,14).Notably,alopecuroide F(1)represent...
关键词：Sophora alopecuroides ALKALOIDS Structure elucidation Anti-inflammatory activity Biological activitiy Configuration determination 
Alopecuroidines A-C, three matrine-derived alkaloids from the seeds of Sophora alopecuroides被引量：1
《Chinese Chemical Letters》2021年第12期4058-4062,共5页Xiang Yuan Zhenyuan Li Ziming Feng Jianshuang Jiang Yanan Yang Peicheng Zhang 
supported by grants from CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-1-010, China);the Drug Innovation Major Project (No. 2018ZX09711001-008, China)。
Three matrine-derived alkaloids, alopecuroidine A(1), alopecuroidine B(2 a) and alopecuroidine C(2 b)were isolated from the seeds of Sophora alopecuroides. Their structures were elucidated by extensive spectroscopic a...
关键词：ALKALOIDS Sophora alopecuroides X-ray diffraction ANTI-PROLIFERATIVE Apoptosis 
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