Matrine-loaded self-adhesive swelling microneedle for inflammation regulation to improve eczema treatment  

作　　者：Jiale Shen Jiarui Wang Meng Wu Yan Shi Minhyeock Lee Zhiguo Wang Ming Kong 

机构地区：[1]College of Marine Life Sciences,Ocean University of China,Qingdao 266003,China [2]Department of Burn and Plastic Surgery,the Affiliated Hospital of Qingdao University,Qingdao University,Qingdao 266021,China [3]Department of Biotechnology,College of Life Sciences and Biotechnology,Korea University,Seoul 02841,Republic of Korea

出　　处：《Marine Life Science & Technology》2024年第3期535-546,共12页海洋生命科学与技术（英文）

基　　金：funded by Natural Science Founda-tion of Shandong Province(ZR2022MC033);Qingdao Science&Technology Benefiting People Project(24-1-8-smjk-11-nsh).

摘　　要：Eczema is a common chronic dermatological disease.Conventional treatments exhibit limited efficacy due to fast drug release resulting in short-term relief.Development of a new treatment strategy that enables sustained drug release and longterm maintenance on the skin surface is necessary.A self-adhesive swelling microneedle patch(SDSMNs)was designed and constructed using a two-step casting method.The adhesive substrate was prepared by blending gelatin and dopamine via oxidation of NaIO4,so it could adhere onto the skin surface as well as withstand repeated bending movement without detachment.The swelling needles were fabricated using polyvinyl alcohol(PVA)and polyvinylpyrrolidone(PVP),which could swell by absorbing interstitial fluid and release the drug in a controlled manner.SDSMNs also showed desirable antibacterial activities toward E.coli and S.aureus.The adhesive microneedles loaded with matrine(MAT-SDSMNs),an antiinflammatory Chinese medicine,dramatically relieved eczema symptoms through IL-17 mediated inflammation responses.The use of MAT-SDSMNs significantly decreased the infiltration of inflammation cells and level of inflammatory cytokines,reduced the skin thickness,and increased collagen deposition fraction compared with conventional ointment or subcutaneous injection.The results suggested that MAT-SDSMNs can improve eczema treatment by regulating the local inflammatory microenvironment,providing a simple,self-administered sustainable strategy for eczema treatment.

关 键 词：Self-adhesive swelling microneedle ECZEMA MATRINE Inflammation regulation 

分 类 号：R751[医药卫生—皮肤病学与性病学]