Matrine, oxymatrine, and compound Kushen injection from the roots of Sophora flavescens: an overview of their anticancer activities  

作　　者：Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan 

机构地区：[1]Faculty of Applied Sciences,UCSI University,56000 Cheras,Kuala Lumpur,Malaysia [2]School of Foundation Studies,Xiamen University Malaysia,Bandar Sunsuria,43900 Sepang,Selangor,Malaysia [3]Secretariat of International Society for Mangrove Ecosystems(ISME),Faculty of Agriculture,University of the Ryukyus,Okinawa 903-0129,Japan

出　　处：《Journal of Chinese Pharmaceutical Sciences》2022年第5期321-333,共13页中国药学（英文版）

摘　　要：In the present review,we updated current information on the chemistry,contents,and anticancer properties of matrine(MT),oxymatrine(OMT),and compound Kushen injection(CKI).The anticancer properties were focused on lung,breast,and liver cancer cells because they are most susceptible.Sources of information were from Google,Google Scholar,PubMed,PubMed Central,Science Direct,PubChem,J-Stage,Directory of Open Access Journals(DOAJ),and China National Knowledge Infrastructure(CNKI).Reference was also made on botanical websites,such as Flora of China and World Flora Online.MT and OMT are dominant quinolizidine alkaloids from the roots of Sophora flavescens(Kushen)of the family Fabaceae.Against lung,breast,and liver cancer cells,MT and OMT inhibit cell proliferation;induce cell cycle arrest,apoptosis,and autophagy;restrict angiogenesis;and inhibit cell metastasis,invasion,and migration.The processes involve various molecular targets and signaling pathways.CKI is a traditional Chinese medicine(TCM)composed of root extracts of S.flavescens and Smilax glabra(Baituling)of the family Smilacaceae.With MT and OMT as major components,CKI has been approved for the treatment of cancer in China more than 20 years ago.In recent years,systematic reviews and meta-analysis have been undertaken to evaluate the anticancer effects of CKI.When CKI is used alone and in combination with chemotherapy of western medicine,there is much to be learned concerning their interactions besides their individual and integrated efficacy.Some perspectives of MT,OMT,and CKI are discussed,and their suggestions for future research are provided.

关 键 词：INJECTION INVASION ROOTS 

分 类 号：R284[医药卫生—中药学]