New polychlorinated bibenzyls from Rhododendron minutiflorum  

作　　者：Yang-Li Zhu Li Deng Yu Tang Xian-Zhe Fan Yang Han Mei Pan Li-Jun Zhang Hai-Bing Liao 

机构地区：[1]State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,Collaborative Innovation Center for Guangxi Ethnic Medicine,School of Chemistry and Pharmaceutical Sciences,Guangxi Normal University,Guilin 541004,People’s Republic of China [2]Guangxi Key Laboratory of Citrus Biology,Guangxi Academy of Specialty Crops,Guilin 541004,People’s Republic of China [3]Guilin Pharma Company,Guilin 541007,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2023年第1期709-717,共9页应用天然产物（英文）

基　　金：The Natural Science Foundation of China(32160109,31800294);the Natural Science Foundation of Guangxi Province of China(2018GXNSFBA138006,2019AC20231);Educational Department of Guangxi(2018KY0089);the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(CMEMR2017-A07,2020-A09);Joint cultivation base of biology and medicine graduate student between Guangxi Normal University and Guilin Pharma Company.

摘　　要：Five new polychlorinated bibenzyls(1-5)along with 3 known compounds(6-8)were isolated from the stems and leaves of Rhododendron minutiflorum.The chemical structures of all the isolates were determined by spectroscopic methods,and compounds 1 and 2 were further verified by single-crystal X-ray diffraction analyses.Compounds 1-5 were halogenated compounds which bear three to five chlorine atoms in their chemical structures.Biologi-cally,compounds 2,5 and 6 showed varying degrees of toxicity toward the Asian citrus psyllid(Diaphorina citri)with LD_(50) values 27.15,17.02 and 16.20 mg/L,respectively.These values were comparable to the positive control matrine(LD_(50)=11.86 mg/L),which were calculated using observations on day 6.Meanwhile,compound 4 hadα-glucosidase inhibitory activity with IC_(50) value of 17.87±0.74μM.

关 键 词：Rhododendron minutiflorum Polychlorinated bibenzyls MATRINE Insecticidal activity Diaphorina citri α-Glucosidase inhibitory activity ACARBOSE 

分 类 号：O62[理学—有机化学]