TOXICITY

作品数：1135被引量：2825H指数：21
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相关机构：中国人民解放军海军医学研究所中国科学院中南大学青岛大学更多>>
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Inhibitory effect of ferroptosis inhibitor toxicity induced by cobalt nanoparticles through reactive oxygen species
《中国组织工程研究》2025年第34期7310-7317,共7页Wang Chen Zhang Weinan Shen Jining Liu Fan Yuan Jishan Liu Yake 
国家自然科学基金面上项目(82172519),项目负责人:刘璠;国家自然科学基金青年科学基金项目(82002282),项目负责人:刘雅克。
BACKGROUND:Soft tissue damage induced by cobalt nanoparticles is currently the most noticeable complication in patients with artificial joint prostheses.Therefore,an effective therapeutic strategy is needed to limit t...
关键词：cobalt nanoparticle ARTHROPLASTY ferroptosis inhibitor ferroptosis reactive oxygen species DEFERIPRONE metal implant detoxify nanobiomedicine pathway FIBROBLAST 
A Bayesian network meta-analysis of EGFR-tyrosine kinase inhibitor treatments in patients with EGFR mutation-positive non-small cell lung cancer☆
《Cancer Pathogenesis and Therapy》2025年第2期135-146,共12页Jianqiong Yin Jing Huang Min Ren Rui Tang Linshen Xie Jianxin Xue 
supported by the National Natural Science Foundation of China(No.82373021);1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYYC23010);the Natural Science Foundation of Science and Technology Department of Sichuan Province(No.2023ZYD0094);the National Clinical Research Center for Geriatrics(No.Z2021JC001).
Background:To date,no direct comparisons have been performed to compare the effectiveness of all epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)against EGFR mutation-positive non-small cell lung...
关键词：Non-small cell lung cancer EGFR-TKI Network meta-analysis SURVIVAL TOXICITY 
Mechanistic insight on nanomaterial-induced reactive oxygen species formation
《Journal of Environmental Sciences》2025年第5期200-210,共11页Jianzhong Cao Qingchun Wu Xuting Liu Xiangyu Zhu Chunfeng Huang Xinyu Wang Yang Song 
supported by the National Natural Science Foundation of China(No.22176206).
Reactive oxygen species(ROS)are closely related to cell death,proliferation and inflammation.However,excessive ROS levels may exceed the cellular oxidative capacity and cause irreversible damage.Organisms are often in...
关键词：NANOMATERIALS Reactive oxygen species(ROS) TOXICITY MITOCHONDRIA Oxidative stress 
A novel treatment approach using vitamin B12-conjugated sericin for mitigating nanodiamond-induced toxicity in darkling beetles
《Insect Science》2025年第2期551-584,共34页Marwa Saad Nabila Selim Lamia M.El-Samad 
The escalating use of nanodiamonds(NDs)has raised concerns about their ecotoxicological impact,prompting exploration of therapeutic interventions.This paper pioneers the examination of Vitamin B12-conjugated sericin(V...
关键词：Blaps polychresta molecular biochemical and microscopic analyses multiorgan assessment nanodiamond toxicity therapeutic interventions vitamin B12-conjugated sericin 
Photochemical properties and toxicity of fluoroquinolone antibiotics impacted by complexation with metal ions in different pH solutions
《Journal of Environmental Sciences》2025年第4期149-158,共10页Shengkai Cao Peng Zhang Heming Song Linke Ge Junfeng Niu 
supported by the National Natural Science Foundation of China(Nos.21976045 and 22076112);China Scholarship Council(CSC)Scholarship(Nos.202208610125 and 202308610123);Shaanxi Key Laboratory of Environmental Monitoring and Forewarning of Trace Pollutants(No.SHJKFJJ202318);the Key Research and Development Program of Shaanxi Province(No.2024SF-YBXM-567).
Acid-base dissociable antibiotic-metal complexes are known to be emerging contaminants in the aquatic environments.However,little information is available on the photochemical properties and toxicity of these complex ...
关键词：FLUOROQUINOLONE Photochemical properties Metal coordination Spectral analysis TOXICITY 
Therapeutic potential of the citrus flavonoid hesperidin and its aglycone hesperetin against chemotherapy-induced toxicity
《Traditional Medicine Research》2025年第4期31-48,共18页Yu-Su Wang Wei-Jian Chen Zi-Yao Mo Yun-Jing He Ke Nie 
Innovative Team Project of Ordinary Universities in Guangdong Province(No.2022KCXTD016).
Chemotherapy-induced toxicity(CIT)remains a major concern in cancer patients undergoing chemotherapy.New approaches to ameliorate the side effects of chemotherapy are urgently needed.Recently,the nutritional value of ...
关键词：chemotherapy-induced toxicity citrus flavonoids HESPERIDIN HESPERETIN 
Metal ion transport in maize:survival in a variable stress environment Author links open overlay panel
《Journal of Genetics and Genomics》2025年第3期297-306,共10页Kangqi Wang Ziqi Wu Man Zhang Xueyao Lu Jinsheng Lai Meiling Zhang Yi Wang 
supported by grants from the Biological Breeding-National Science and Technology Major Project(2023ZD04072);the National Natural Science Foundation of China(32302660,32025004,and 31921001).
Maize(Zea mays)is the most widely cultivated crop in the world.Maize production is closely linked to the extensive uptake and utilization of various mineral nutrients.Potassium(K),calcium(Ca),and magnesium(Mg)are esse...
关键词：MAIZE Essential mineral elements Metal ionIon toxicity TRANSPORTER 
Toxicity of Zearalenone in Animals and Its Biological Detoxification
《Journal of Northeast Agricultural University(English Edition)》2025年第1期86-96,共11页Shi Zhuo Xie Ting Liu Nengwen Dong Na Bi Chongpeng Li Feng 
Supported by China Agriculture Research System(CARS-35);the Natural Science Foundation of Heilongjiang Province of China(LH2021C038)。
Zearalenone(ZEN)is a non-steroidal estrogenic mycotoxin biosynthesized by the polyketide reaction,which has estrogenic effects and triggers toxic effects,such as reproductive toxicity,hepatotoxicity,genotoxicity,and i...
关键词：Zearalenone(ZEN) METABOLISM biological detoxification TOXICITY 
Intratracheal instillation for the testing of pulmonary toxicity in mice-Effects of instillation devices and feed type on inflammation
《Animal Models and Experimental Medicine》2025年第2期378-386,共9页Niels Hadrup Michael Guldbrandsen Eva Terrida Katja M.S.Bendtsen Karin S.Hougaard Nicklas R.Jacobsen Ulla Vogel 
This work was supported by the Focused Research Effort on Chemicals in the Working Environment(FFIKA)from the Danish Government.
Background:Inhalation exposure is the gold standard when assessing pulmonary tox-icity.However,it typically requires substantial amounts of test material.Intratracheal instillation is an alternative administration tec...
关键词：INHALATION MOUSE PULMONARY TOXICITY 
Constructing high-biosecurity MoS_(2)-based anodes for rapid and efficient lithium storage
《Nano Research》2025年第2期358-366,共9页Yixin Wang Ruxia Qiao Xueying Zheng Wangyan Wu Hao Yang Stephanie Ling Jie Lee Jian Peng Jinyu Rong Wei Luo Sijie Lin 
This work was financially supported by the National Natural Science Foundation of China(No.22176150);the Fundamental Research Funds for the Central Universities.
Lithium-ion batteries that integrate electrochemical performance and safety considerations offer advantages to curb the reliance on fossil fuels while minimizing the potential environmental risks.Transition metal disu...
关键词：electrospun fibers Li-ion battery MoS_(2) In_(2)O_(3) hollow fiber low-toxicity anode 
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