Toxicity of Zearalenone in Animals and Its Biological Detoxification  

作　　者：Shi Zhuo Xie Ting Liu Nengwen Dong Na Bi Chongpeng Li Feng 

机构地区：[1]College of Animal Sciences and Technology,Northeast Agricultural University,Harbin 150030,China

出　　处：《Journal of Northeast Agricultural University(English Edition)》2025年第1期86-96,共11页东北农业大学学报(英文版)

基　　金：Supported by China Agriculture Research System(CARS-35);the Natural Science Foundation of Heilongjiang Province of China(LH2021C038)。

摘　　要：Zearalenone(ZEN)is a non-steroidal estrogenic mycotoxin biosynthesized by the polyketide reaction,which has estrogenic effects and triggers toxic effects,such as reproductive toxicity,hepatotoxicity,genotoxicity,and immunotoxicity in organism.Due to its impact on human and animal health and the economic losses engendered by ZEN,detoxification strategies for contaminated foods and feeds to reduce or eliminate the toxic effects of ZEN by chemical,physical and biological methods are crucial.Detoxification by microbial means has broad application prospects,with the advantages of high efficiency,high specificity,mild conditions of action,no harmful metabolites,and safety.It may help to improve the function of intestinal barriers so that the intestinal epithelial barrier is more resistant to mycotoxins,and other pathogenic microorganisms.This article provided an overview of the metabolic pathways and animal toxicity of ZEN in organism,and summarized the effects of the current research status,detoxification mechanisms and in vivo applications of ZEN biodetoxification,in order to provide a reference for the prevention and control of ZEN.

关 键 词：Zearalenone(ZEN) METABOLISM biological detoxification TOXICITY 

分 类 号：S859.8[农业科学—临床兽医学]