FLUOROQUINOLONE

作品数:58被引量:160H指数:7
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相关领域:医药卫生农业科学更多>>
相关作者:张文波吴移谋尹卫国余敏君张晓辉更多>>
相关机构:南华大学北京分子科学国家实验室温州医科大学华西医科大学附属第一医院更多>>
相关期刊:《Journal of Ocean University of China》《Open Journal of Urology》《Open Journal of Medical Microbiology》《Acta Pharmacologica Sinica》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划更多>>
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Photochemical properties and toxicity of fluoroquinolone antibiotics impacted by complexation with metal ions in different pH solutions
《Journal of Environmental Sciences》2025年第4期149-158,共10页Shengkai Cao Peng Zhang Heming Song Linke Ge Junfeng Niu 
supported by the National Natural Science Foundation of China(Nos.21976045 and 22076112);China Scholarship Council(CSC)Scholarship(Nos.202208610125 and 202308610123);Shaanxi Key Laboratory of Environmental Monitoring and Forewarning of Trace Pollutants(No.SHJKFJJ202318);the Key Research and Development Program of Shaanxi Province(No.2024SF-YBXM-567).
Acid-base dissociable antibiotic-metal complexes are known to be emerging contaminants in the aquatic environments.However,little information is available on the photochemical properties and toxicity of these complex ...
关键词:FLUOROQUINOLONE Photochemical properties Metal coordination Spectral analysis TOXICITY 
A Dietary Source of High Level of Fluoroquinolone Tolerance in mcr-Carrying Gram-Negative Bacteria
《Research》2024年第3期105-121,共17页Tianqi Xu Dan Fang Fulei Li Zhiqiang Wang Yuan Liu 
the National Key Research and Development Program of China(2021YFD1801000 and 2018YFA0903400);the National Natural Science Foundation of China(32222084,32172907,and 32002331);Jiangsu Agricultural Science and Technology Innovation Fund(CX(21)2010);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),and 111 Project D18007.
The emergence of antibiotic tolerance,characterized by the prolonged survival of bacteria following antibiotic exposure,in natural bacterial populations,especially in pathogens carrying antibiotic resistance genes,has...
关键词:OVERCOME thereby ADDITIVE 
Subinhibitory Levels of Fluoroquinolones Result in Enrichment of the Membrane Proteome of Staphylococcus aureus
《Journal of Ocean University of China》2023年第5期1439-1445,共7页XU Xiaoxiao LIN Hong GUO Jiamin LIU Pei SUN Haixin 
funded by the Professional Innovation and Integration Project of Qingdao University(2020)。
Staphylococcus aureus is a common marine foodborne pathogen.In this study,antibiotics ciprofloxacin and enrofloxacin were used to induce drug-resistance in S.aureus.The differentially expressed proteins(DEPs)were anal...
关键词:subinhibitory environment marine foodborne pathogen PROTEOMICS FLUOROQUINOLONE 
Rapid detection of fluoroquinolone residues in aquatic products based on a gold-labeled microwell immunochromatographic assay被引量:1
《Food Quality and Safety》2022年第4期597-607,共11页Jiaxu Xiao Hongfei Yang Liangni Qin Jixiang Liang Long Li Xiaohui Fan Dapeng Peng 
funded by the Key Research and Development Program of Hubei Province(CN)(No.2020BBB079);the Fundamental Research Funds for the Central Universities(2662022DKPY007);the HZAU-AGIS Cooperation Fund(SZYJY2022024),China.
Objectives:Fluoroquinolones(FQs)are widely used in aquaculture,and their residues have caused many problems threatening human health.Here,this study aims to develop a colloidal gold immunochromatographic strip based o...
关键词:FLUOROQUINOLONES colloidal gold MICROWELL PURIFICATION RESIDUES 
Design,synthesis,and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors
《Journal of Pharmaceutical Analysis》2022年第4期653-663,共11页Yuan-Yuan Hei Si Wang Xiao-Xiao Xi Hai-Peng Wang Yuanxu Guo Minhang Xin Congshan Jiang Shemin Lu San-Qi Zhang 
Financial support from the National Natural Science Foundation of China(Grant No.:81673354)is gratefully acknowledged.
MicroRNA-21(miRNA-21)is highly expressed in various tumors.Small-molecule inhibition of miRNA-21 is considered to be an attractive novel cancer therapeutic strategy.In this study,fluoroquinolone derivatives A1eA43 wer...
关键词:Quinolone derivatives Small-molecule miRNA-21 inhibitor Antitumor agent Drug design 
Exposure to trace levels of metals and fluoroquinolones increases inflammation and tumorigenesis risk of zebrafish embryos被引量:2
《Environmental Science and Ecotechnology》2022年第2期12-22,共11页Dantong Jia Ruijie Zhang Jian Shao Wei Zhang Leilei Cai Weiling Sun 
the National Natural Science Foundation of China(Grant No.51925901 and 51879001).
Exposure to trace-level heavy metals and antibiotics may elicit metabolic disorder,alter protein expression,and then induce pathological changes in zebrafish embryos,despite negligible physiological and developmental ...
关键词:FLUOROQUINOLONE Metal INFLAMMATION Tumor Oxidative stress 
Construction of the Molecular Structure Model of the Zhaotong Lignite Using Simulation and Experiment Data
《Chinese Journal of Structural Chemistry》2022年第3期137-147,I0011,共12页ZHANG Dian-Kai LI Yan-Hong CHANG Li-Ping ZI Chang-Yu ZHANG Yuan-Qin TIAN Guo-Cai ZHAO Wen-Bo 
supported by the National Natural Science Foundation of China (21766013);Analysis and Testing Foundation of Kunming University of Science and Technology (2020M20192208021)
Aiming to better understand the physiochemical properties of lignite, we select Zhaotong lignite as object and adopt simulation and experiment data to construct its molecular structure. Firstly, the important paramete...
关键词:fluoroquinolone amide derivatives Hep-3B cell Capan-1cell HL60 cell anti-proliferative activity comparative molecular field analysis 
CoMFA Study on Anti-proliferative Activity of Fluoroquinolone Amide Derivatives被引量:4
《Chinese Journal of Structural Chemistry》2022年第3期241-247,I0014,共8页ENG Hui CAO Jing-Pei FENG Chang-Jun 
supported by the National Natural Science Foundation of China (21676292, 21075138);special fund of State Key Laboratory of Structure Chemistry (2016028)
The in vitro anti-proliferative activity(pICi,i=hp,ca,hl)of fluoroquinolone(rhodanineα,β-unsaturated ketone)amide compounds,referred to as“fluoroquinolone amide derivatives(FQADs)”towards Hep-3B,Capan-1 and HL60 c...
关键词:fluoroquinolone amide derivatives Hep-3B cell Capan-1cell HL60 cell anti-proliferative activity comparative molecular field analysis 
Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolones Drugs With Nickel(Ⅱ) Metal Ion:Infrared and Electronic Spectroscopy
《光谱学与光谱分析》2021年第6期1976-1981,共6页Samar O.Aljazzar 
the deanship of scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding program。
Quinolone has a broad spectrum of synthetic antibiotics with a strong therapeutic effect and quinolone is a term used for chemical treatments used to treat a powerful bacteria.Quinolones are divided into 4 generations...
关键词:QUINOLONE FLUOROQUINOLONE NICKEL FTIR CHELATES UV-Vis Octahedral geometry 
Shifting hierarchy of the conjunctival florae in the patients employed a long-time topical fluoroquinolone
《International Journal of Ophthalmology(English edition)》2020年第10期1554-1560,共7页Xue-Hui Zhang Ying Tian Yi-Yi Wen Shuang-Yong Wang 
Supported by the National Natural Science Foundation of China(No.81870631)。
AIM:To observe the shifting hierarchy of the conjunctival florae in the patients who employed a long-time topical fluoroquinolone and characterize the consequent variations of their antibiotic sensitivity and virulenc...
关键词:FLUOROQUINOLONE conjunctival flora antibiotic sensitivity VIRULENCE corneal ulcer 
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