MICROWELL

作品数：13被引量：21H指数：3
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相关领域：医药卫生生物学更多>>
相关机构：浙江大学更多>>
相关期刊：《Journal of Integrative Agriculture》《Research》《Bioactive Materials》《Food Quality and Safety》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金高等学校学科创新引智计划更多>>
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Biomimetic lubricant-grafted surfaces on laser-textured microwell arrays with multifunctionality
《Friction》2024年第12期2707-2725,共19页Xiaorui SONG Zhiqiang HOU Zhehao GAN Yuyao HU Hongyu ZHENG Yongling WU Mingming LIU 
supported by the National Natural Science Foundation of China(No.52205313);Natural Science Foundation of Shandong Province(ZR2022QE161),China Postdoctoral Science Foundation(2023M734093);the Tribology Science Fund of State Key Laboratory of Solid Lubrication(LSL-2312);Scientific Innovation Project for Young Scientists in Shandong Provincial Universities(2023KJ145,2023KJ148).
Recently,various slippery liquid-infused porous surfaces(SLIPS)have been fabricated for the protection of various materials.However,these SLIPSs are limited by their underlying storage structure and superficial lubric...
关键词：laser texture LUBRICANT covalent grafting omniphobicity ANTI-ICING 
Rapid detection of fluoroquinolone residues in aquatic products based on a gold-labeled microwell immunochromatographic assay被引量：1
《Food Quality and Safety》2022年第4期597-607,共11页Jiaxu Xiao Hongfei Yang Liangni Qin Jixiang Liang Long Li Xiaohui Fan Dapeng Peng 
funded by the Key Research and Development Program of Hubei Province(CN)(No.2020BBB079);the Fundamental Research Funds for the Central Universities(2662022DKPY007);the HZAU-AGIS Cooperation Fund(SZYJY2022024),China.
Objectives:Fluoroquinolones(FQs)are widely used in aquaculture,and their residues have caused many problems threatening human health.Here,this study aims to develop a colloidal gold immunochromatographic strip based o...
关键词：FLUOROQUINOLONES colloidal gold MICROWELL PURIFICATION RESIDUES 
Development of digital organ-on-a-chip to assess hepatotoxicity and extracellular vesicle-based anti-liver cancer immunotherapy被引量：4
《Bio-Design and Manufacturing》2022年第3期437-450,共14页Guohua Wu Jianguo Wu Zihan Li Shengyu Shi Di Wu Xuanbo Wang Han Xu Hui Liu Yixiao Huang Rending Wang Jia Shen Zhihong Dong Shuqi Wang 
supports from the General Program (No. 31871016);the National Key Scientific Instrument and Equipment Development Projects (No. 61827806) from the National Natural Science Foundation of China;the National Major Science and Technology Projects (No. 2018ZX10732401-003-007);the National Key Research and Development Program (No. 2016YFC1101302) from the Ministry of Science and Technology of China;the National Natural Science Foundation of China (No. 81770719);Science and Technology Department of Zhejiang Province (No. 2019C03029)
Organ-on-a-chip systems have been increasingly recognized as attractive platforms to assess toxicity and to develop new therapeutic agents.However,current organ-on-a-chip platforms are limited by a“single pot”design...
关键词：DIGITAL Organ-on-a-chip Microwell array Microspheres Extracellular vesicles 
A microwell-based impedance sensor on an insertable microneedle for real-time in vivo cytokine detection被引量：1
《Microsystems & Nanoengineering》2021年第6期139-150,共12页Naixin Song Pengfei Xie Wen Shen Hanju Oh Yejia Zhang Flavia Vitale Mehdi Javanmard Mark G.Allen 
This work was supported by DARPA Cooperative Agreement HR0011-16-2-0026 under the ElectRX program managed by Dr.E.Van Giesen;Fabrication was conducted at the Singh Center for Nanotechnology at the University of Pennsylvania,which is supported by the National Science Foundation NNCI2025608.
Impedance-based protein detection sensors for point-of-care diagnostics require quantitative specificity,as well as rapid or real-time operation.Furthermore,microfabrication of these sensors can lead to the formation ...
关键词：NEEDLE utilized INSERTION 
Ultra-thin temperature controllable microwell array chip for continuous real-time high-resolution imaging of living single cells
《Chinese Chemical Letters》2021年第11期3446-3449,共4页Yuanyuan Wu Lei Zhao Yaran Chang Liang Zhao Guangsheng Guo Xiayan Wang 
supported by the National Natural Science Foundation of China(Nos.21625501,21936001);the Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910005017).
Single-cell imaging,a powerful analytical method to study single-cell behavior,such as gene expression and protein profiling,provides an essential basis for modern medical diagnosis.The coding and localization functio...
关键词：Ultra-thin microchip Temperature controllable Living single cells One-step patterning Continuous culture High-resolution imaging 
Double emulsion-pretreated microwell culture for the in vitro production of multicellular spheroids and their in situ analysis
《Microsystems & Nanoengineering》2021年第3期73-84,共12页Fuyang Qu Shirui Zhao Guangyao Cheng Habibur Rahman Qinru Xiao Renee Wan Yi Chan Yi-Ping Ho 
This work was supported by the Research Grants Council of the Hong Kong Special Administrative Region,China(Project number:CUHK 14201317 and C5011-19GF);the VC Discretionary Fund;the Chinese University of Hong Kong(Project number:8601014).
Multicellular spheroids have served as a promising preclinical model for drug efficacy testing and disease modeling.Many microfluidic tech no logies,in eluding those based on water-oil-water double emulsions,have been...
关键词：EMULSION sized CULTURE 
A matrigel-free method to generate matured human cerebral organoids using 3D-Printed microwell arrays被引量：4
《Bioactive Materials》2021年第4期1130-1139,共10页Cheng Chen Venkatakrishnan Rengarajan Andrew Kjar Yu Huang 
We thank Hemdeep Patel from the ResinWorks3D company for providing us the high-resolution 3D printed mold devices as a gift.We also thank Angela Clyde for the initial discussion on device design.We thank Utah State University’s College of Engineering Undergraduate Research Program(EURP)for supporting Andrew Kjar.We also thank Utah State University Research Catalyst(RC)program for supporting Cheng Chen.
The current methods of generating human cerebral organoids rely excessively on the use of Matrigel or other external extracellular matrices(ECM)for cell micro-environmental modulation.Matrigel embedding is problematic...
关键词：Cortical wrinkling Cortical folding 3D culture Biomanufacturing Embryoid body spheroid MICROFABRICATION 
Low-Cost and Scalable Platform with Multiplexed Microwell Array Biochip for Rapid Diagnosis of COVID-19被引量：3
《Research》2021年第1期94-102,共9页Yang Wang Kaiju Li Gaolian Xu Chuan Chen Guiqin Song Zaizai Dong Long Lin Yu Wang Zhiyong Xu Mingxia Yu Xinge Yu Binwu Ying Yubo Fan Lingqian Chang Jia Geng 
supported by the Special Research Funding on COVID19 from Sichuan Province of China(Grant No.2020YFS0004);Science and Technology Department,Ministry of Education of the People’s Republic of China,the NSFC(No.32071407 and No.62003023);the 111 Project(No.B13003);Innovation Research Plan from the Shanghai Municipal Education Commission(ZXWF082101/056);Exploratory Project of Natural Science Foundation of Shanghai(19ZR1476000);Beijing Advanced Innovation Center for Biomedical Engineering at Beihang University。
Sensitive detection of SARS-CoV-2 is of great importance for inhibiting the current pandemic of COVID-19.Here,we report a simple yet efficient platform integrating a portable and low-cost custom-made detector and a no...
关键词：instrument diagnosis SPECIFICITY 
Single-Cell Microwell Platform Reveals Circulating Neural Cells as a Clinical Indicator for Patients with Blood-Brain Barrier Breakdown被引量：2
《Research》2021年第1期1530-1542,共13页Yu Zhang Antony R.Warden Khan Zara Ahmad Yanlei Liu Xijun He Minqiao Zheng Xinlong Huo Xiao Zhi Yuqing Ke Hongxia Li Sijia Yan Wenqiong Su Deng Cai Xianting Ding 
supported by the National Natural Science Foundation of China(Nos.81871448,81701353,and 82073380);the Science and Technology commission of Shanghai Municipality(2017SHZDZX01);the MedicalEngineering Cross Foundation of Shanghai Jiao Tong University(Nos.19X190020154,YG2016MS60,ZH2018QNA54,ZH2018QNA49,and YG2021QN129);the Shanghai Sailing Program(19YF1446900).
Central nervous system diseases commonly occur with the destruction of the blood-brain barrier.As a primary cause of morbidity and mortality,stroke remains unpredictable and lacks cellular biomarkers that accurately q...
关键词：Blood CD45 MCAO 
Mapping a mammalian adult adrenal gland hierarchy across species by microwell-seq被引量：4
《Cell Regeneration》2020年第1期110-121,共12页Shujing Lai Lifeng Ma Weigao E Fang Ye Haide Chen Xiaoping Han Guoji Guo 
This work was supported by grants from the National Natural Science Foundation of China(81770188,31722027,and 31701290);the National Key Program on Stem Cell and Translational Research(2017YFA0103401).
Recently,single-cell RNA-seq technologies have been rapidly updated,leading to a revolution in biology.We previously developed Microwell-seq,a cost-effective and high-throughput single cell RNA sequencing(scRNA-seq)me...
关键词：ADRENAL MAPPING seq 
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