HESPERETIN

作品数：14被引量：37H指数：3
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相关领域：医药卫生更多>>
相关作者：徐红侴桂新王峥涛张俊平张珉更多>>
相关机构：上海中医药大学第二军医大学浙江清华长三角研究院武汉大学更多>>
相关期刊：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《Traditional Medicine Research》《Journal of Environmental Science and Engineering(A)》《Chinese Journal of Integrative Medicine》更多>>
相关基金：国家自然科学基金更多>>
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Hesperetin Relaxes Depolarizing Contraction in Human Umbilical Vein by Inhibiting L-Type Ca~(2+)Channel
《Chinese Journal of Integrative Medicine》2025年第5期412-421,共10页Kritsana Tipcome Wattana B.Watanapa Katesirin Ruamyod 
Supported by National Research Council of Thailand Thesis Grant for Doctoral Degree Student and the Siriraj Graduate Scholarship(both to K.T.);the Faculty of Medicine Siriraj Hospital,Mahidol University(to W.B.W.and K.R.)。
Objective:To study hesperetin-induced vasorelaxation after depolarizing contraction in human umbilical veins(HUVs)to elucidate the role of L-type Ca~(2+)channel(LTCC)and related signaling pathway.Methods:Isometric ten...
关键词：cardiovascular diseases NUCLEOTIDES cyclic HESPERETIN calcium channels L-TYPE PHOSPHODIESTERASE umbilical veins 
Therapeutic potential of the citrus flavonoid hesperidin and its aglycone hesperetin against chemotherapy-induced toxicity
《Traditional Medicine Research》2025年第4期31-48,共18页Yu-Su Wang Wei-Jian Chen Zi-Yao Mo Yun-Jing He Ke Nie 
Innovative Team Project of Ordinary Universities in Guangdong Province(No.2022KCXTD016).
Chemotherapy-induced toxicity(CIT)remains a major concern in cancer patients undergoing chemotherapy.New approaches to ameliorate the side effects of chemotherapy are urgently needed.Recently,the nutritional value of ...
关键词：chemotherapy-induced toxicity citrus flavonoids HESPERIDIN HESPERETIN 
Interventional effect of hesperetin on N-methyl-N’-nitro-Nnitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis
《World Journal of Gastroenterology》2025年第16期66-88,共23页Zhao-Feng Liang Yu-Meng Xu Jia-Jia Song Zi-Han Gao Hui Qian Xue-Zhong Xu 
Supported by the National Natural Science Foundation of China,No.81602883;Technology Development Project of Jiangsu University,No.20220516;Postgraduate Research and Practice Innovation Program of Jiangsu Province,No.KYCX233765.
BACKGROUND Hesperetin,a flavonoid predominantly present in citrus fruits,exhibits significant intervention effects on both the initiation and progression of gastric cancer.However,the specific mechanisms underlying th...
关键词：HESPERETIN Gastric cancer N-methyl-N’-nitro-N-nitrosoguanidine EXOSOMES Circ0008274 
Fabrication of micro spherulitic particles of carbamazepine-hesperetin cocrystal via QESD with enhanced manufacturability and dissolution
《Particuology》2024年第10期11-21,共11页Jinbo Ouyang Lishan Liu Zichen Ning Zhuoshan Gong Limin Zhou Feiqiang He Zhi Gao Li Xu Shichao Du Huaiyu Yang 
supported by National Natural Science Foundation of China(grant Nos.22068002 and 22178054);Jiangxi ProvincialNatural Science Foundation(grant Nos.20224ACB213007_and 20232BBH80015);Jiangxi Province Key Laboratory of Synthetic Chemistry(grant No.JXSC202209).
Granulation is an effective method for improving the flowability of drugs, particularly when they are in needle form. Carbamazepine-hesperetin (CBZ-HPE) cocrystal is a needle-like crystal with low solubility and poor ...
关键词：Carbamazepine-hesperetin cocrystal Quasi-emulsion solventdiffusion(QESD) technique Microspheres FLOWABILITY Dissolution rate 
Hesperetin derivative 2a inhibits lipopolysaccharide-induced acute liver injury in mice via downregulation of circDcbld2被引量：1
《Acta Pharmacologica Sinica》2024年第2期354-365,共12页Li-jiao Sun Xin Chen Sai Zhu Jin-jin Xu Xiao-feng Li Shao-xi Diao Ying-li Yang Jin-yu Liu Jia-nan Wang Ying-yin Sun Cheng Huang Xiao-ming Meng Hua Wang Xiong-wen Lv Jun Li 
supported by the National Natural Science Foundation of China(Nos.U19A2001,82070628,82300722);funds from the University Synergy Innovation Programme of Anhui Province(GXXT-2020-063 and GXXT-2020-025);the China Postdoctoral Science Foundation(2022M710178).
Acute liver injury(ALI)is a complex,life-threatening inflammatory liver disease,and persistent liver damage leads to rapid decline and even failure of liver function.However,the pathogenesis of ALI is still not fully ...
关键词：acute liver injury CircDcbld2 hesperetin derivatives HD-2a inflammation JAK2/STAT3 
铁皮石斛醋酸乙酯部位化学成分研究被引量：10
《中草药》2021年第17期5218-5225,共8页周宇娟 王俊豪 薛亚甫 徐红 侴桂新 王峥涛 
国家重点研发计划(2017YFC1700801);国家自然科学基金资助项目(U19A2009);云南省王峥涛专家工作站(2018IC146)。
目的进一步研究铁皮石斛Dendrobium officinale活性醋酸乙酯部位的化学成分。方法运用大孔树脂、MCI、硅胶、凝胶(Sephadex LH-20)、ODS等柱色谱、制备薄层色谱及制备高效液相色谱法等分离技术,进行化合物的分离纯化,根据^(1)H-NMR、^(1...
关键词：铁皮石斛 loliolide 柚皮素 HESPERETIN 甘草素 2-(4-hydroxy-3-methoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-3-oxo-l-propanol 异甘草素 
Combinatory effect of hesperetin and mesenchymal stem cells on the deteriorated lipid profile,heart and kidney functions and antioxidant activity in STZ-induced diabetic rats被引量：2
《BIOCELL》2020年第1期27-39,共13页Osama M.AHMED Mohamed A.HASSAN Ablaa S.SALEH 
This study aimed to assess the effect of hesperetin and/or bone marrow-derived mesenchymal stem cells(BM-MSCs)on disturbed lipid profile,heart and kidney functions,oxidative stress and antioxidant defense system in st...
关键词：BM-MSCs HESPERETIN Streptozotocin-induced diabetes 
Hesperetin induces glyoxalase 1 enhancement in SH-SY5Y cells cultured with high glucose via Nrf2/ARE activation
《中国药理学与毒理学杂志》2019年第9期702-702,共1页ZHANG Meng-ya LIU Yao-wu 
National Natural Science Foundation of China(81371210)
OBJECTIVE To investigate the neuroprotective effects of hesperetin on central neurons under chronic high glucose,and the relationship to glyoxalase 1(Glo-1),a cytoprotective enzyme.METHODS The human neuroblas⁃toma SH-...
关键词：HESPERETIN NEUROPROTECTION glyoxalase 1 Nrf2/ARE pathway GSK-3Β 
Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D-α-tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine被引量：2
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2019年第3期273-281,共9页Su-fang GU Li-ying WANG Ying-jie TIAN Zhu-xian ZHOU Jian-bin TANG Xiang-rui LIU Hai-ping JIANG You-qing SHEN 
Project supported by the National Natural Science Foundation of China(Nos.51773176,51522304,and U1501243);the Natural Science Foundation of Zhejiang Province(No.LY17H300002),China
Hesperetin,an abundant bioactive component of citrus fruits,is poorly water-soluble,resulting in low oral bioavailability.We developed new formulations to improve the water solubility,antioxidant activity,and oral abs...
关键词：HESPERETIN D-α-Tocopheryl polyethylene glycol 1000 succinate(TPGS) PHOSPHATIDYLCHOLINE Antioxidant activity Oral absorption 
Hesperetin derivative-12 (HDND-12) regulates macrophage polarization by modulating JAK2/STAT3 signaling pathway被引量：15
《Chinese Journal of Natural Medicines》2019年第2期122-130,共9页KONG Ling-Na LIN Xiang HUANG Cheng MA Tao-Tao MENG Xiao-Ming HU Chao-Jie WANG Qian-Qian LIU Yan-Hui SHI Qing-Ping LI Jun 
supported by the Key Fund Project of Anhui Education Department(No.KJ2016A364);National Natural Science Foundation of China(No.81473268)
Macrophages show significant heterogeneity in function and phenotype, which could shift into different populations of cells in response to exposure to various micro-environmental signals. These changes, also termed as...
关键词：HESPERETIN Derivative-12 MACROPHAGE Polarization JAK2/STAT3 RAW264.7 cells 
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