PHOSPHODIESTERASE

作品数：79被引量：148H指数：6
导出分析报告
相关领域：医药卫生更多>>
相关作者：朱永通徐雯曹云燕崔倩倩蔡圣朝更多>>
相关机构：南方医科大学南方医院浙江大学安徽中医药大学华中农业大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家科技支撑计划北京市自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders
《Neural Regeneration Research》2025年第8期2302-2303,共2页Asma Boulksibat Alessandra Tempio Barbara Bardoni 
The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular processes.In the brain,these p...
关键词：formation processes finally 
Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?
《Neural Regeneration Research》2025年第6期1701-1702,共2页Giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli 
The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than...
关键词：GATEWAY HOMEOSTASIS preserve 
Discovery of highly potent phosphodiesterase-1 inhibitors by a combined-structure free energy perturbation approach
《Acta Pharmaceutica Sinica B》2024年第12期5357-5369,共13页Zhe Li Mei-Yan Jiang Runduo Liu Quan Wang Qian Zhou Yi-You Huang Yinuo Wu Chang-Guo Zhan Hai-Bin Luo 
supported by the National Key R&D Program of China(2023YFF1205102);National Natural Science Foundation of China(82273856,22077143,21977127,22377023);the Research Project(31511010402,China);Fundamental Research Funds for Hainan University(KYQD(ZR)-21031,KYQD(ZR)-21108 and XTCX2022JKA01,China);Science Foundation of Hainan Province(KJRC2023B10,China).
Accurate receptor/ligand binding free energy calculations can greatly accelerate drug discov-ery by identifying highly potent ligands.By simulating the change from one compound structure to another,the relative bindin...
关键词：Free energy perturbation Drug design Phosphodiesterase 1 Relative binding free energy Molecular simulation 
Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2
《Nano Research》2024年第4期2886-2898,共13页Xiaoqi Zhao Xuemeng Guo Mei Pang Weigen Qiu Zhenyu Luo Qing Lin Yichao Lu Hang Yin Sijie Wang Huihui Liu Junlei Zhang Lihua Luo Jian You 
supported by the National Natural Science Foundation of China(No.81973246);Public Welfare Project of Zhejiang Natural Science Foundation(No.GF22H308848).
Cancer is a predominant culprit behind worldwide death and accounts for up to 10 million deaths every year.Chemotherapy is the primary therapeutic method employed for cancer in clinical settings and is essential in co...
关键词：chemotherapy VINORELBINE tumor Invasion lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2(ENPP2) 
Headaches and Erectile Dysfunction Medications at UTH-Kara (Togo)
《World Journal of Neuroscience》2023年第4期228-235,共8页Léhleng Agba Nyinèvi K. Anayo Hola K. Sikpa Mensah K. Guinhouya Tchilabalo M. Kpatcha Vinyo K. Kumako Damelan Kombate Komi Assogba Agnon A. Balogou 
Introduction: Headaches are a common symptom affecting individuals worldwide, including in the tropical zone, and have been extensively studied in Togo. Phosphodiesterase-5 inhibitors, commonly prescribed for erectile...
关键词：HEADACHE Phosphodiesterase-5 Inhibitors Erectile Dysfunction TOGO Sub-Saharan Africa 
Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility
《Asian Journal of Andrology》2023年第5期608-615,共8页Yi-Ting Yang Bin Yan Yu-Hua Li Li-Na Guo Wei-Wei Wang Li-Jie Liu He-Guo Yu Hua Diao 
supported by the Shanghai Municipal Health Commission Young Foundation(No.20194Y0270);Science and Technology Commission of Shanghai Municipality(No.20ZR1448100).
Phosphodiesterase(PDE)inhibitors can improve sperm motility in patients with asthenozoospermia.However,the most commonly reported nonselective PDE inhibitor pentoxifylline and PDE5 inhibitor sildenafil have the disadv...
关键词：PENTOXIFYLLINE phosphodiesterase 10A SILDENAFIL sperm motility spontaneous acrosome reaction 
Arabidopsis pollen-specific glycerophosphodiester phosphodiesterase-like genes are essential for pollen tube tip growth
《Journal of Integrative Plant Biology》2023年第8期2001-2017,共17页Chong Wang Hao Cheng Wenjing Xu Jingshi Xue Xinguo Hua Guimin Tong Xujun Ma Chuanping Yang Xingguo Lan Shi-Yi Shen Zhongnan Yang Jirong Huang Yuxiang Cheng 
supported by the Fundamental Research Funds for the Central Universities(2572021DT01);the National Natural Science Foundation of China(31770637);the Innovation Project of State Key Laboratory of Tree Genetics and Breeding(2014A01);the Heilongjiang Touyan Innovation Team Program(Tree Genetics and Breeding Innovation Team)。
In angiosperms,pollen tube growth is critical for double fertilization and seed formation.Many of the factors involved in pollen tube tip growth are unknown.Here,we report the roles of pollenspecific GLYCEROPHOSPHODIE...
关键词：Arabidopsis thaliana cell wall integrity cellulose deposition male sterility pollen-specific GDPD-LIKE pollen tube tip growth 
Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia:Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis被引量：6
《Acta Pharmaceutica Sinica B》2023年第3期1180-1191,共12页Qian Zhou Meiling Le Yiyi Yang Wenjuan Wang Yuqi Huang Quan Wang Yijing Tian Meiyan Jiang Yong Rao Hai-Bin Luo Yinuo Wu 
supported by the National Natural Science Foundation of China(22077143,21977127,and 21877134);Science Foundation of Guangzhou City(201904020023,China);Fundamental Research Funds for Hainan University(KYQD(ZR)-21031,China);Science of Guangdong Province(2019A1515011883,China);Guangdong Province Higher Vocational Colleges&Schools Pearl River Scholar Funded Scheme(2016,China).
Vascular dementia(VaD)is the second commonest type of dementia which lacks of efficient treatments currently.Neuroinflammation as a prominent pathological feature of VaD,is highly involved in the development of VaD.In...
关键词：Vascular dementia Phosphodiesterase 1(PDE1) NEUROINFLAMMATION Structural-based drug design cAMP/CREB axis 
Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia被引量：4
《Acta Pharmaceutica Sinica B》2022年第7期3103-3112,共10页Xu-Nian Wu Qian Zhou Ya-Dan Huang Xi Xie Zhe Li Yinuo Wu Hai-Bin Luo 
supported by the Natural Science Foundation of China(21877134,22077143,81903542,and 21977127);Science Foundation of Guangzhou City(201904020023,China);Fundamental Research Funds for Hainan University(KYQD(ZR)21031,China);Science Foundation of Guangdong Province(2019A1515011883,China);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093,China);Guangdong Province Higher Vocational Colleges&Schools Pearl River Scholar Funded Scheme(2016,China)。
Our previous study demonstrated that phosphodiesterase 8(PDE8)could work as a potential target for vascular dementia(Va D)using a chemical probe 3a.However,compound 3a is a chiral compound which was obtained by chiral...
关键词：Phosphodiesterase 8(PDE8) Vascular dementia Structure-based drug design MM-GB/SA Free energy prediction Structure—activity relationship Binding potencies 
Discovery of a highly specific ^(18)F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination
《Acta Pharmaceutica Sinica B》2022年第4期1963-1975,共13页Zhiwei Xiao Huiyi Wei Yi Xu Ahmed Haider Junjie Wei Shiyu Yuan Jian Rong Chunyu Zhao Guocong Li Weibin Zhang Huangcan Chen Yuefeng Li Lingling Zhang Jiyun Sun Shaojuan Zhang Hai-Bin Luo Sen Yan Qijun Cai Lu Hou Chao Che Steven H.Liang Lu Wang 
the support of K.C.Wong Education Foundation (China);financially supported by the National Natural Science Foundation of China (No.82071974);Shenzhen Basic Research Project (JCYJ20180503182116931, China);Guangdong Basic and Applied Basic Research Foundation (2020A1515011192, 2018A0303130052, China);Guangzhou Key Research Program on Brain Science (202007030008, China);the Fundamental Research Funds for the Central Universities (21619104, 21621051, China)
As a member of cyclic nucleotide phosphodiesterase(PDE)enzyme family,PDE10A is in charge of the degradation of cyclic adenosine(cAMP)and guanosine monophosphates(cGMP).While PDE10A is primarily expressed in the medium...
关键词：Phosphodiesterase 10A PET radioligand 18F Spirocyclic iodonium ylide Nonhuman primate Target occupancy 
全选清除导出
共8页<12345678>
检索报告 对象比较 聚类工具 使用帮助 返回顶部