Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?  

作　　者：Giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli 

机构地区：[1]Department of Molecular and Translational Medicine,University of Brescia,Brescia,Italy

出　　处：《Neural Regeneration Research》2025年第6期1701-1702,共2页中国神经再生研究（英文版）

摘　　要：The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关 键 词：GATEWAY HOMEOSTASIS preserve 

分 类 号：R741[医药卫生—神经病学与精神病学]