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MOUSE: 作品数：1516被引量：3022H指数：19; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：姜晓波窦晓兵刘以训李婷婷马锐更多>>; 相关机构：昆盈企业股份有限公司北京大学中国科学院中国农业大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

The role of SRPK1-mediated phosphorylation of SR proteins in the chromatin configuration transition of mouse germinal vesicle oocytes: 《Journal of Biomedical Research》2025年第2期198-208,I0013-I0015,共14页Xia Wang Shuai Zhou Haojie Yin Jian Han Yue Hu Siqi Wang Congjing Wang Jie Huang Junqiang Zhang Xiufeng Ling Ran Huo; National Natural Science Foundation of China(Grant Nos.32070838 and 82301874);Open Fund of State Key Laboratory of Reproductive Medicine,Nanjing Medical University(Grant No.SKLRM K202102)。; Meiotic resumption in mammalian oocytes involves nuclear and organelle structural changes,notably the chromatin configuration transition from a non-surrounding nucleolus(NSN)to surrounding nucleolus(SN)in germinal ves...; 关键词：OOCYTE CHROMATIN nuclear speckle SR protein PHOSPHORYLATION SRPK1

cTAGE5 is involved in the assembly of Golgi ring in mouse primordial follicle: 《Science Bulletin》2025年第5期643-647,共5页Haowei Wu Yaqing Wang Jiayi Li Yan Qin Min Chen Zhiming Shen Fangfang Dong Xiuhong Cui Liang Liu Zhiheng Xu Fei Gao; National Key R&D Program of China(2022YFC2702400);National Natural Science Foundation of China(32270902,31970785 and 32170855);Faculty Resources Project of the College of Life Sciences,Inner Mongolia University(2022-104).; Human oocytes contain a highly specialized compartment known as the Balbiani body(Bb).The Bb is a nonmembrane structure densely packed with mitochondria,RNA and Golgi[1],[2].In some non-mammalian species,the Bb serves...; 关键词：determination. specialized packed

PPAN modulates mouse male germ cell development via maintaining nucleolar homeostasis: 《Genes & Diseases》2025年第1期25-28,共4页Yu Tian Yufan Wang Qing Tian Guiping Cheng Li-quan Zhou; supported by the National Natural Science Foundation of China(No.NSFC 32170820);the National Key R&D Program of China(No.2022YFC2702704);the Program for HUST Academic Frontier Youth Team.; In mammalian cells,the nucleolus serves as a factory for organizing ribosomal RNA(rRNA)synthesis and ribosomal biogenesis.Moreover,by interacting with rRNA genes and heterochromatin,nucleolus also functions in chromat...; 关键词：RRNA HOMEOSTASIS IMPLANTATION

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease: 《Neural Regeneration Research》2025年第2期574-586,共13页Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon; supported by funding from Parkinson Canada;funded by a scholarship from Parkinson Canada;a scholarship from Fonds d’Enseignement et de Recherche (FER) (Faculty of Pharmacy, Université Laval); There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after diagnosis.Given that preclinical and clinical studies suggest benefits of dietary n-3 poly...; 关键词：6-HYDROXYDOPAMINE DOPAMINE dopamine transporter EXERCISE neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Conditional knockout of the NSD2 gene in mouse intestinal epithelial cells inhibits colorectal cancer progression: 《Animal Models and Experimental Medicine》2025年第2期322-331,共10页Mengyuan Li Hanxue Chen Xingjiu Yang Wenlong Zhang Chengyan Ma Qinghong Wang Xinpei Wang Ran Gao; supported by the National Key Research and Development Program of China (2022YFF0710705);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2021-I2M-1-0 13);funding support from the Special Research Fund for Central Universities;Peking Union Medical College (3332022182);the 111 Project (B20095); Background:Nuclear receptor-binding SET domain 2(NSD2)is a histone methyltrans-ferase,that catalyzes dimethylation of lysine 36 of histone 3(H3K36me2)and is asso-ciated with active transcription of a series of genes.N...; 关键词：colorectal cancer NSD2^(fl/fl)-Vil1-Cre mice nuclear receptor-binding SET domain 2

Intratracheal instillation for the testing of pulmonary toxicity in mice-Effects of instillation devices and feed type on inflammation: 《Animal Models and Experimental Medicine》2025年第2期378-386,共9页Niels Hadrup Michael Guldbrandsen Eva Terrida Katja M.S.Bendtsen Karin S.Hougaard Nicklas R.Jacobsen Ulla Vogel; This work was supported by the Focused Research Effort on Chemicals in the Working Environment(FFIKA)from the Danish Government.; Background:Inhalation exposure is the gold standard when assessing pulmonary tox-icity.However,it typically requires substantial amounts of test material.Intratracheal instillation is an alternative administration tec...; 关键词：INHALATION MOUSE PULMONARY TOXICITY

Single-cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever: 《Animal Models and Experimental Medicine》2025年第1期30-43,共14页Yizhen Yuan Qian Chen Zhe Li Fangzhou Cai Dan Li Wei Wang; Chinese Academy of Medical Sciences Initiative for Innovative Medicine,Grant/Award Number:2021-I2M-1-035 and 2022-I2M-1-011。; Background:Dengue fever,an acute insect-borne infectious disease caused by the dengue virus(DENV),poses a great challenge to global public health.Hepatic involve-ment is the most common complication of severe dengue a...; 关键词：adaptive immunity dengue fever model liver injury single-cell sequencing

The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes: 《Animal Models and Experimental Medicine》2025年第1期126-141,共16页Avia Paz Kareem Midlej Osayd Zohud Iqbal MLone Fuad A.Iraqi; Tel-Aviv University(TAU)。; Background:Over the past few decades,a threefold increase in obesity and type 2 diabetes(T2D)has placed a heavy burden on the health-care system and society.Previous studies have shown correlations between obesity,T2D...; 关键词：collaborative cross mouse DIABETES host genetic background memory impairments OBESITY

Bone marrow-derived microglia confer neuroprotection to a mouse model of amyotrophic lateral sclerosis: 《Neural Regeneration Research》2024年第12期2586-2587,共2页Beka Solomon; Amyotrophic lateral sclerosis(ALS) is a neurodegenerative disease that causes the progressive loss of both upper and lower motor neurons in the brain,brainstem,and spinal cord.The exact mechanisms of ALS are still unc...; 关键词：SCLEROSIS BRAINSTEM

Identification of hub genes and pathways in mouse with cold exposure: 《Frigid Zone Medicine》2024年第4期233-241,共9页Xu Wang Hongbo Hu Ying Zhang; Background:Cold exposure is linked to numerous diseases,yet the changes in key genes and pathways in mice under cold exposure remain unexplored.Understanding these alterations could offer insights into the mechanisms ...; 关键词：cold exposure hub genes PATHWAY adipose tissue

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