PATHWAY

作品数：1499被引量：5004H指数：25
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相关机构：吉林大学上海交通大学中国科学院清华大学更多>>
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Targeting the brain’s glymphatic pathway:A novel therapeutic approach for cerebral small vessel disease
《Neural Regeneration Research》2026年第2期433-442,共10页Yuhui Ma Yan Han 
supported by the National Natural Science Foundation of China,No.82274304(to YH);the Major Clinical Study Projects of Shanghai Shenkang Hospital Development Center,No.SHDC2020CR2046B(to YH);Shanghai Municipal Health Commission Talent Plan,No.2022LJ010(to YH).
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological me...
关键词：AQUAPORIN-4 ASTROCYTES cerebral amyloid angiopathy cerebral small vessel disease cerebrospinal fluid diffusion tensor image analysis along the perivascular space glymphatic system interstitial fluid perivascular space therapeutic strategies 
Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury
《Neural Regeneration Research》2025年第10期2807-2822,共16页Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong Gu Dong Ming 
supported by grants from the Natural Science Foundation of Tianjin(General Program),Nos.23JCYBJC01390(to RL),22JCYBJC00220(to XC),and 22JCYBJC00210(to QL).
Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes...
关键词：central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach 
Sotatercept:A novel therapeutic approach for pulmonary arterial hypertension through transforming growth factor-βsignaling modulation
《World Journal of Methodology》2025年第3期63-69,共7页Jyoti Bajpai Mehul Saxena Akshyaya Pradhan Surya Kant 
Pulmonary arterial hypertension(PAH)is a progressive disease marked by degeneration of the lung’s blood vessels.As the disease progresses,the resistance to blood flow in the pulmonary arteries increases,putting a str...
关键词：Pulmonary artery DRUGS Mean pulmonary artery pressure Transforming growth factor-βpathway PROTEIN 
C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury
《Neural Regeneration Research》2025年第8期2231-2244,共14页Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi 
supported by the National Natural Science Foundation of China(Key Program),No.11932013;the National Natural Science Foundation of China(General Program),No.82272255;Armed Police Force High-Level Science and Technology Personnel Project;The Armed Police Force Focuses on Supporting Scientific and Technological Innovation Teams;Key Project of Tianjin Science and Technology Plan,No.20JCZDJC00570(all to XC)。
Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand...
关键词：apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method 
Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury
《Neural Regeneration Research》2025年第7期1900-1918,共19页Hang Yang Yulei Xia Yue Ma Mingtong Gao Shuai Hou Shanshan Xu Yanqiang Wang 
supported by Yuan Du Scholars,Clinical Research Center of Affiliated Hospital of Shandong Second Medical University,No.2022WYFYLCYJ02;Weifang Key Laboratory,Weifang Science and Technology Development Plan Project Medical Category,No.2022YX093.
The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically revie...
关键词：calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein 
PathActMarker:an R package for inferring pathway activity of complex diseases
《Frontiers of Computer Science》2025年第3期123-124,共2页Xingyi LI Jun HAO Zhelin ZHAO Junming LI Xingyu LIAO Min LI Xuequn SHANG 
supported in part by the National Natural Science Foundation of China(Grant No.62202383);Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012602);the National Key Research and Development Program of China(No.2022YFD1801200).
1 Introduction The process of complex diseases is closely linked to the disruption of key biological pathways,it is crucial to identify the dysfunctional pathways and quantify the degree of dysregulation at the indivi...
关键词：pathway activity DYSREGULATION complex diseases biological pathways disruption key biological pathwaysit identify dysfunctional pathways 
HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia
《Genes & Diseases》2025年第3期23-26,共4页Run Yang Xin Chen Siyi Wu Chenlong Li Ying Chen Yaoyao Fu Aijuan He Duan Ma Jing Ma Tianyu Zhang 
supported by the National Natural Science Foundation of China(No.82271889,82371173);the National Key Research and Development Program of China(No.2021YFC2701000);the Natural Science Foundation Project of Shanghai Science and Technology Innovation Action Plan(China)(No.23ZR1409400);Shanghai Science and Technology Commission of China(No.21DZ2200700).
Microtia,a congenital malformation affecting the external and middle ear,arises from disruptions during the development of embryonic branchial arches and cranial neural crest cells(CNCCs),making it the second most pre...
关键词：aberrant gene expression skeletal patterningand congenital malformation maxillofacial birth defect hoxb conductive hearing loss retinoic acid pathway embryonic branchial arches 
Effect of ranibizumab on diabetic retinopathy via the vascular endothelial growth factor/STAT3/glial fibrillary acidic protein pathway
《World Journal of Diabetes》2025年第5期234-253,共20页Ye-Ting Lin Jian Tan Yu-Lin Tao Wei-Wen Hu Yi-Cang Wang Jing Huang Qiong Zhou Ang Xiao 
Supported by the Natural Science Foundation of Jiangxi Province,No.20242BAB25489;National Natural Science Foundation of China,No.82260211 and No.81460092;Key Research and Development Project in Jiangxi Province,No.20203BBG73058;Chinese Medicine Science and Technology Project in Jiangxi Province,No.2020A0166。
BACKGROUND Diabetic retinopathy(DR)is the leading cause of vision loss in patients with diabetes.The vascular endothelial growth factor(VEGF)pathway plays a critical role in the pathogenesis of DR,and ranibizumab,an a...
关键词：Diabetic retinopathy RANIBIZUMAB Early stage Vascular endothelial growth factor Signal transducer and activator of transcription 3 Glial fibrillary acidic protein 
Exercise training benefits pancreatic islet by modulating the insulinlike growth factor 1/phosphatidylinositol 3-kinase/protein kinase B pathway
《World Journal of Diabetes》2025年第5期271-282,共12页Ya-Wen Wu Chu-Yan Wu Feng Lin Jun-Ying Wu 
BACKGROUND Diabetes is characterized by insulin resistance as well as impaired insulin production,withβ-cell dysfunction playing a critical role in disease progression.Exercise is known to improve insulin sensitivity...
关键词：Exercise training DIABETES Insulin-like growth factor 1 Phosphatidylinositol 3-kinase/protein kinase B ISLET 
Qingda Granule Attenuates Hypertension-Induced Cardiac Damage via Regulating Renin-Angiotensin System Pathway
《Chinese Journal of Integrative Medicine》2025年第5期402-411,共10页LONG Lin-zi TAN Ling XU Feng-qin YANG Wen-wen LI Hong-zheng LIU Jian-gang WANG Ke ZHAO Zhi-ru WANG Yue-qi WANG Chao-ju WEN Yi-chao HUANGMing-yan QU Hua FU Chang-geng CHEN Ke-ji 
Supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2022D01C556);National Natural Science Foundation of China(No.82104678);Science and Technology Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A05013)。
Objective:To assess the efficacy of Qingda Granule(QDG)in ameliorating hypertensioninduced cardiac damage and investigate the underlying mechanisms involved.Methods:Twenty spontaneously hypertensive rats(SHRs)were use...
关键词：blood pressure cardiac damage HYPERTENSION Qingda Granule renin-angiotensin system 
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