DYSREGULATION

作品数：167被引量：524H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：杨燕青李亮廉哲雄姚远王菲菲更多>>
相关机构：中国科学技术大学山东中医药大学附属眼科医院第二军医大学徐州医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金泰国研究基金更多>>
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Multidisciplinary management of pituitary macroadenoma
《World Journal of Methodology》2025年第3期131-145,共15页Gladness Aluyi-Osa Ayuba Suleman Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa Marco Zeppieri 
BACKGROUND Pituitary macroadenomas represent a significant challenge in clinical management due to their variable presentations and complex treatment considerations.This manuscript explores the multidisciplinary appro...
关键词：PITUITARY MACROADENOMA MULTIDISCIPLINARY Hormonal dysregulation 
Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy
《Neural Regeneration Research》2025年第8期2264-2278,共15页You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao 
supported by the National Natural Science Foundation of China,No.82271214(to ZY);the Natural Science Foundation of Hubei Province of China,No.2022CFB109(to ZY)。
Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments.The current therapeutic strategies,primarily based on cholinest...
关键词：Alzheimer’s disease glial cells GLYCOLYSIS neuronal metabolism PATHOGENESIS therapeutic targets 
The Role of Childhood Stress in Inflammatory Skin Conditions: A Neuroimmune Investigation
《Modern Research in Inflammation》2025年第1期20-32,共13页Marissa Ruppe Colin Burnette Emily Deehan Emily Woolhiser Haily Fritts Kelly Frasier Aspynn Owsley Savannah K. Fakhouri Veronica Rodriguez 
Emerging evidence indicates that childhood stressors, such as familial conflict, bullying, academic pressure, and traumatic events, can significantly worsen inflammatory skin conditions like atopic dermatitis (AD) and...
关键词：Childhood Stressors Neuroimmune Pathways Cortisol Dysregulation Psychophysiological Response Stress Management Pro-Inflammatory Cytokines Atopic Dermatitis PSORIASIS 
Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats
《World Journal of Hepatology》2025年第3期140-151,共12页Chao Ren Li Cha Shu-Yue Huang Guo-Hui Bai Jin-Hui Li Xin Xiong Yu-Xing Feng Dui-Ping Feng Long Gao Jin-Yu Li 
Supported by the National Natural Science Foundation of China,No.82200650;the Key Research and Development Projects of Shanxi Province,No.202102130501014;the Natural Science Foundation of Shanxi Province,No.202203021211021,No.202203021212046,and No.20210302123258.
BACKGROUND The pathogenesis of hepatic encephalopathy(HE)remains unclear,and the classical theory of ammonia toxicity lacks sufficient justification.AIM To investigate the potential of bile acids as intervention targe...
关键词：Hepatic encephalopathy Total bile acid THIOACETAMIDE G protein-coupled bile acid receptor 1 Liver cirrhosis 
Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease
《Neural Regeneration Research》2025年第3期808-810,共3页Iqira Saeed Linlin Ma 
Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeost...
关键词：HOMEOSTASIS CLINICAL subsequent 
Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma
《World Journal of Gastrointestinal Oncology》2025年第1期199-206,共8页Radu Cristian Poenaru Elena Milanesi Andrei Marian Niculae Anastasia-Maria Dobre Catalina Vladut Mihai Ciocîrlan Daniel Vasile Balaban Vlad Herlea Maria Dobre Mihail Eugen Hinescu 
Supported by Romanian Ministry of Research,Innovation and Digitization,No.PN23.16.02.04 and No.31PFE/30.12.2021.
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11%in the United States.As for other types of tumors,such as colorec...
关键词：CARCINOMA Pancreatic ductal Fatty acid transport Gene expression Biomarkers 
BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation
《World Journal of Gastrointestinal Oncology》2025年第1期214-225,共12页Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-Wu Zhong Qiang Ma Xiao-Lan Guo 
Supported by the Scientific Research Development Plan Project or the Scientific Research Foundation for Advanced Talents,Affiliated Hospital of North Sichuan Medical College,No.2023MPZK017,No.2023ZD001,No.2023-2ZD002,and No.2023GC009;Science and Technology Support Program of Nanchong,No.22SXQT0001;Youth Medical Innovation Research Project,or Medical Research Project of Sichuan Province,No.Q23047 and No.S23020;Development of a Scientific Research Plan for the Doctoral Scientific Research Foundation of the North Sichuan Medical College,No.CBY22-ZDA03.
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic agents.Telomeres are DNA-protein complexes located at the te...
关键词：Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins 
Trophic transfer of carbon-14 from algae to zebrafish leads to its blending in biomolecules and the dysregulation of metabolism via isotope effect
《National Science Review》2025年第1期149-160,共12页Shipeng Dong Renquan Deng Hang Zeng Pengfei Xue Sijie Lin Dongmei Zhou Liang Mao 
supported by the National Natural Science Foundation of China(22125602,U2067215,22341601,22076078 and 22376095).
Carbon-14(C-14)has been a major contributor to the human radioactive exposure dose,as it is released into the environment from the nuclear industry in larger quantities compared to other radionuclides.This most abunda...
关键词：organically bound carbon-14 trophic transfer isotope effects metabolism dysregulation isotopic substitution 
TFEB/LAMP2 contributes to PM_(0.2)-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes
《Journal of Environmental Sciences》2024年第11期117-127,共11页Ben Li Ting Liu Yongmei Shen Jiangnan Qin Xiaohan Chang Meiqiong Wu Jianquan Guo Liangpo Liu Cailing Wei Yi Lyu Fengjie Tian Jinzhu Yin Tong Wang Wenping Zhang Yulan Qiu 
supported by the National Science Foundation of China(No.21906100);the Applied Basic Research Project of Shanxi Province(Nos.201901D211333,201901D211327,and 202203021211246).
Atmospheric particulatematter(PM)exacerbates the risk factor for Alzheimer’s and Parkinson’s diseases(PD)by promoting the alpha-synuclein(α-syn)pathology in the brain.However,the molecular mechanisms of astrocytes ...
关键词：PM_(0.2) ASTROCYTES α-Synuclein Autophagy-lysosome 
KMT2D deficiency leads to cellular developmental disorders and enhancer dysregulation in neural-crest-containing brain organoids
《Science Bulletin》2024年第22期3533-3546,共14页Ziyun Shan Yingying Zhao Xiuyu Chen Guodong Zhan Junju Huang Xuejie Yang Chongshen Xu Ning Guo Zhi Xiong Fang Wu Yujian Liu He Liu Biyuan Chen Bingqiu Chen Jiaoyang Sun Jiangping He Yiping Guo Shangtao Cao Kaixin Wu Rui Mao Guangming Wu Lihui Lin Xiaobing Zou Jie Wang Jiekai Chen 
supported by National Science Foundation of China(32225012);National Key R&D Program of China(2019YFA0110200);Health@Inno HK Program launched by Innovation Technology Commission of the Hong Kong SAR,China,Youth Innovation Promotion Association,Chinese Academy of Sciences(Jie Wang),National Science Foundation of China(32000414,32000503,and 32000501);The Science and Technology Program of Guangzhou 201804020052 and 202102021039;the Pearl River Talent Recruitment Program(2021ZT09Y233);Basic Research Project of Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,(GIBHBRP23-01,GIBHBRP23-02);Frontier Science Research Program of the CAS ZDBS-LY-SM007;Science and Technology Planning Project of Guangdong Province,China(2023B1212060050 and 2023B1212120009)。
KMT2D,a H3K4me1 methyltransferase primarily regulating enhancers,is a leading cause of KABUKI syndrome.This multisystem disorder leads to craniofacial and cognitive abnormalities,possibly through neural crest and neur...
关键词：KMT2D ENHANCER NICHE Cerebral organoids Single-cell multiome 
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