DYSREGULATION

作品数：170被引量：528H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：杨燕青李亮廉哲雄姚远王菲菲更多>>
相关机构：中国科学技术大学山东中医药大学附属眼科医院第二军医大学徐州医科大学更多>>
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Multidisciplinary management of pituitary macroadenoma
《World Journal of Methodology》2025年第3期131-145,共15页Gladness Aluyi-Osa Ayuba Suleman Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa Marco Zeppieri 
BACKGROUND Pituitary macroadenomas represent a significant challenge in clinical management due to their variable presentations and complex treatment considerations.This manuscript explores the multidisciplinary appro...
关键词：PITUITARY MACROADENOMA MULTIDISCIPLINARY Hormonal dysregulation 
Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy
《Neural Regeneration Research》2025年第8期2264-2278,共15页You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao 
supported by the National Natural Science Foundation of China,No.82271214(to ZY);the Natural Science Foundation of Hubei Province of China,No.2022CFB109(to ZY)。
Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments.The current therapeutic strategies,primarily based on cholinest...
关键词：Alzheimer’s disease glial cells GLYCOLYSIS neuronal metabolism PATHOGENESIS therapeutic targets 
PathActMarker:an R package for inferring pathway activity of complex diseases
《Frontiers of Computer Science》2025年第3期123-124,共2页Xingyi LI Jun HAO Zhelin ZHAO Junming LI Xingyu LIAO Min LI Xuequn SHANG 
supported in part by the National Natural Science Foundation of China(Grant No.62202383);Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012602);the National Key Research and Development Program of China(No.2022YFD1801200).
1 Introduction The process of complex diseases is closely linked to the disruption of key biological pathways,it is crucial to identify the dysfunctional pathways and quantify the degree of dysregulation at the indivi...
关键词：pathway activity DYSREGULATION complex diseases biological pathways disruption key biological pathwaysit identify dysfunctional pathways 
miRNA dysregulation in Duchenne muscular dystrophy comorbidities
《World Journal of Experimental Medicine》2025年第2期142-149,共8页Subhashree Sivakumar Archana Rajavel Venkataraman Viswanathan Evangeline Ann Daniel Prakash Gangadaran Raja Natesan Sella 
BACKGROUND Duchenne muscular dystrophy(DMD)is a neuromuscular disorder caused by mutations in the dystrophin gene.DMD is reported to coexist with other comorbidities,although the occurrence of the triad,autism spectru...
关键词：Duchenne muscular dystrophy DYSTROPHIN MIRNA Autism spectrum disorder Phosphatase and tensin Inflammatory response 
The Role of Childhood Stress in Inflammatory Skin Conditions: A Neuroimmune Investigation
《Modern Research in Inflammation》2025年第1期20-32,共13页Marissa Ruppe Colin Burnette Emily Deehan Emily Woolhiser Haily Fritts Kelly Frasier Aspynn Owsley Savannah K. Fakhouri Veronica Rodriguez 
Emerging evidence indicates that childhood stressors, such as familial conflict, bullying, academic pressure, and traumatic events, can significantly worsen inflammatory skin conditions like atopic dermatitis (AD) and...
关键词：Childhood Stressors Neuroimmune Pathways Cortisol Dysregulation Psychophysiological Response Stress Management Pro-Inflammatory Cytokines Atopic Dermatitis PSORIASIS 
Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats
《World Journal of Hepatology》2025年第3期140-151,共12页Chao Ren Li Cha Shu-Yue Huang Guo-Hui Bai Jin-Hui Li Xin Xiong Yu-Xing Feng Dui-Ping Feng Long Gao Jin-Yu Li 
Supported by the National Natural Science Foundation of China,No.82200650;the Key Research and Development Projects of Shanxi Province,No.202102130501014;the Natural Science Foundation of Shanxi Province,No.202203021211021,No.202203021212046,and No.20210302123258.
BACKGROUND The pathogenesis of hepatic encephalopathy(HE)remains unclear,and the classical theory of ammonia toxicity lacks sufficient justification.AIM To investigate the potential of bile acids as intervention targe...
关键词：Hepatic encephalopathy Total bile acid THIOACETAMIDE G protein-coupled bile acid receptor 1 Liver cirrhosis 
Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease
《Neural Regeneration Research》2025年第3期808-810,共3页Iqira Saeed Linlin Ma 
Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeost...
关键词：HOMEOSTASIS CLINICAL subsequent 
FOXR2 in cancer development:emerging player and therapeutic opportunities
《Oncology Research》2025年第2期283-300,共18页PIAO YANG MOHSEN SHEYKHHASAN REZA HEIDARI MOHSEN CHAMANARA PAOLA DAMA AMIRHOSSEIN AHMADIEH-YAZDI HAMED MANOOCHEHRI HAMID TANZADEHPANAH HANIE MAHAKI NASER KALHOR ASHKAN DIRBAZIYAN SHARAFALDIN AL-MUSAWI 
Cancer,a leading cause of global mortality,remains a significant challenge to increasing life expectancy worldwide.Forkhead Box R2(FOXR2),identified as an oncogene within the FOX gene family,plays a crucial role in de...
关键词：Forkhead Box R2(FOXR2) DYSREGULATION CANCER Therapeutic PROGNOSTIC 
Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma
《World Journal of Gastrointestinal Oncology》2025年第1期199-206,共8页Radu Cristian Poenaru Elena Milanesi Andrei Marian Niculae Anastasia-Maria Dobre Catalina Vladut Mihai Ciocîrlan Daniel Vasile Balaban Vlad Herlea Maria Dobre Mihail Eugen Hinescu 
Supported by Romanian Ministry of Research,Innovation and Digitization,No.PN23.16.02.04 and No.31PFE/30.12.2021.
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11%in the United States.As for other types of tumors,such as colorec...
关键词：CARCINOMA Pancreatic ductal Fatty acid transport Gene expression Biomarkers 
BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation
《World Journal of Gastrointestinal Oncology》2025年第1期214-225,共12页Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-Wu Zhong Qiang Ma Xiao-Lan Guo 
Supported by the Scientific Research Development Plan Project or the Scientific Research Foundation for Advanced Talents,Affiliated Hospital of North Sichuan Medical College,No.2023MPZK017,No.2023ZD001,No.2023-2ZD002,and No.2023GC009;Science and Technology Support Program of Nanchong,No.22SXQT0001;Youth Medical Innovation Research Project,or Medical Research Project of Sichuan Province,No.Q23047 and No.S23020;Development of a Scientific Research Plan for the Doctoral Scientific Research Foundation of the North Sichuan Medical College,No.CBY22-ZDA03.
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic agents.Telomeres are DNA-protein complexes located at the te...
关键词：Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins 
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