FOXR2 in cancer development:emerging player and therapeutic opportunities  

作　　者：PIAO YANG MOHSEN SHEYKHHASAN REZA HEIDARI MOHSEN CHAMANARA PAOLA DAMA AMIRHOSSEIN AHMADIEH-YAZDI HAMED MANOOCHEHRI HAMID TANZADEHPANAH HANIE MAHAKI NASER KALHOR ASHKAN DIRBAZIYAN SHARAFALDIN AL-MUSAWI 

机构地区：[1]Department of Molecular Genetics,College of Arts and Sciences,The Ohio State University,Columbus,OH,USA [2]Cellular and Molecular Research Center,Qom University of Medical Sciences,Qom,Iran [3]Medical Biotechnology Research Center,AJA University of Medical Sciences,Tehran,Iran [4]Toxicology Research Center,AJA University of Medical Sciences,Tehran,Iran [5]Student Research Committee,AJA University of Medical Sciences,Tehran,Iran [6]Research Fellow School of Life Sciences,University of Sussex,Brighton,UK [7]Stem Cell Biology Research Center,Yazd Reproductive Sciences Institute,Shahid Sadoughi University of Medical Sciences,Yazd,Iran [8]The Persian Gulf Marine Biotechnology Research Center,The Persian Gulf Biomedical Sciences Research Institute,Bushehr University of Medical Sciences,Bushehr,Iran [9]Antimicrobial Resistance Research Center,Mashhad University of Medical Sciences,Mashhad,Iran [10]Vascular&Endovascular Surgery Research Center,Mashhad University of Medical Sciences,Mashhad,Iran [11]Department of Mesenchymal Stem Cells,Academic Center for Education,Culture and Research,Qom,Iran [12]Department of Microbiology,Faculty of Medicine,AJA University of Medical Sciences,Tehran,Iran [13]College of Food Sciences,Al-Qasim Green University,Babylon,Iraq

出　　处：《Oncology Research》2025年第2期283-300,共18页肿瘤学研究(英文)

摘　　要：Cancer,a leading cause of global mortality,remains a significant challenge to increasing life expectancy worldwide.Forkhead Box R2(FOXR2),identified as an oncogene within the FOX gene family,plays a crucial role in developing various endoderm-derived organs.Recent studies have elucidated FOXR2-related pathways and their involvement in both tumor and non-tumor diseases.Dysregulation of FOXR2 has been linked to numerous malignant tumors,spanning the brain,nervous system,thyroid,osteosarcoma,Hodgkin lymphoma,colorectal,liver,pancreatic,lung,breast,ovarian,prostate,female genital tract,endometrial,and uterine cancers.Despite extensive research on FOXR2 dysregulation,its practical applications remain underexplored.This review delves into the mechanisms underlying FOXR2 dysregulation during oncogenesis and its implications for cancer diagnosis,prognosis,and treatment.

关 键 词：Forkhead Box R2(FOXR2) DYSREGULATION CANCER Therapeutic PROGNOSTIC 

分 类 号：R730.2[医药卫生—肿瘤]