Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy  

作　　者：You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao 

机构地区：[1]Department of Geriatrics,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China

出　　处：《Neural Regeneration Research》2025年第8期2264-2278,共15页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.82271214(to ZY);the Natural Science Foundation of Hubei Province of China,No.2022CFB109(to ZY)。

摘　　要：Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments.The current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's disease.Recent studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's disease.Alterations in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's disease.Glycolytic changes impact neuronal health and function,thus offering promising targets for therapeutic intervention.The purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and progression.Comprehensive focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关 键 词：Alzheimer’s disease glial cells GLYCOLYSIS neuronal metabolism PATHOGENESIS therapeutic targets 

分 类 号：R749.16[医药卫生—神经病学与精神病学]