Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury  

作　　者：Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong Gu Dong Ming 

机构地区：[1]Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin,China [2]Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion,Tianjin,China [3]Department of Rehabilitation,Tianjin University Tianjin Hospital,Tianjin,China [4]Department of Hand Microsurgery,Tianjin University Tianjin Hospital,Tianjin,China [5]School of Exercise and Health,Tianjin University of Sport,Tianjin,China [6]Department of Biomedical Engineering,the Chinese University of Hong Kong,Hong Kong Special Administrative Region,China

出　　处：《Neural Regeneration Research》2025年第10期2807-2822,共16页中国神经再生研究（英文版）

基　　金：supported by grants from the Natural Science Foundation of Tianjin(General Program),Nos.23JCYBJC01390(to RL),22JCYBJC00220(to XC),and 22JCYBJC00210(to QL).

摘　　要：Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关 键 词：central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach 

分 类 号：R745[医药卫生—神经病学与精神病学]