ISLET

作品数：205被引量：292H指数：8
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Exercise training benefits pancreatic islet by modulating the insulinlike growth factor 1/phosphatidylinositol 3-kinase/protein kinase B pathway
《World Journal of Diabetes》2025年第5期271-282,共12页Ya-Wen Wu Chu-Yan Wu Feng Lin Jun-Ying Wu 
BACKGROUND Diabetes is characterized by insulin resistance as well as impaired insulin production,withβ-cell dysfunction playing a critical role in disease progression.Exercise is known to improve insulin sensitivity...
关键词：Exercise training DIABETES Insulin-like growth factor 1 Phosphatidylinositol 3-kinase/protein kinase B ISLET 
TERT/FOXO1 signaling promotes isletβ-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagy
《World Journal of Diabetes》2025年第5期317-330,共14页Xiao-Tian Lei Xiang-Fen Chen Sheng Qiu Jia-Ying Tang Shan Geng Gang-Yi Yang Qi-Nan Wu 
Supported by National Natural Science Foundation of China,No.82000792;General Project of Chongqing Natural Science Foundation,No.CSTB2023NSCQ-MSX0246 and No.CSTB2022NSCQ-MSX1271;Research Project of the State Administration of Traditional Chinese Medicine on Collaborative Chronic Disease Management of Traditional Chinese Medicine and Western Medicine,No.CXZH2024087;Science and Health Joint Project of Dazu District Science and Technology Bureau,No.DZKJ2024JSYJ-KWXM1002.
BACKGROUND Type 2 diabetes mellitus(T2DM)is a severe global health problem that causes prolonged disease exposure and an elevated risk for chronic complications,posing a substantial health burden.Although therapies,su...
关键词：TERT ATG9A AUTOPHAGY Isletβ-cells Type 2 diabetes mellitus 
Editorial on amylase and the acini–islet–acinar reflex:A new frontier in metabolic health research
《World Journal of Experimental Medicine》2025年第1期6-10,共5页Opeyemi Deji-Oloruntoba Uchenna E Okpete Haewon Byeon 
Supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287,No.NRF-2021S1A5A8062526;Local Government-University Cooperation-Based Regional Innovation Projects,No.2021RIS-003.
This editorial comments on the study by Pierzynowska et al investigating the acini-islet-acinar(AIA)reflex,which integrates the exocrine and endocrine functions of the pancreas.The study investigates whether exogenous...
关键词：ALPHA-AMYLASE Insulin secretion Glucose metabolism Pancreatic signaling Metabolic regulation Acino-insular axis 
Islet dimension and its impact on transplant outcome:A systematic review
《World Journal of Transplantation》2025年第3期212-230,共19页Sipra Rout Pravash R Mishra Appakalai N Balamurugan Praveen Kumar Ravi 
BACKGROUND Not all islet transplants desirably achieve insulin independence.This can be attributed to the microarchitecture and function of the islets influenced by their dimensions.Large islets enhance insulin secret...
关键词：Islet diameter TRANSPLANTATION Islet size Insulin-secretion VIABILITY ENGRAFTMENT Insulin independence Islet transplantation 
Isletβ-cell function preservation by different anti-diabetic treatments in Chinese elderly patients with type 2 diabetes mellitus
《World Journal of Diabetes》2025年第2期81-91,共11页Wei Ling Yan-Chao Wang Yi Huang Yang-Fu Ou Yan-Chun Jiang 
Medical Ethics Committee of the Nanxishan Hospital of Guangxi Zhuang Autonomous Region(Approval No.NXSYY-2024-209).
BACKGROUND The preservation of isletβ-cell function in elderly patients with type 2 diabetes mellitus(T2DM)is a top priority for diabetic control.AIM To assess the preservation of isletβ-cell function among elderly ...
关键词：Type 2 diabetes Elderly β-Cell function Diabetic treatments 
Plantamajoside improves type 2 diabetes mellitus pancreaticβ-cell damage by inhibiting endoplasmic reticulum stress through Dnajc1 up-regulation
《World Journal of Diabetes》2025年第2期183-196,共14页Duo Wang Yuan-Song Wang Hong-Min Zhao Peng Lu Meng Li Wei Li Huan-Tian Cui Zhong-Yong Zhang Shu-Quan Lv 
Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio,No.4(2022).
BACKGROUND Plantamajoside(PMS)has shown potential in mitigating cell damage caused by high glucose(HG)levels.Despite this,the precise therapeutic effects of PMS on type 2 diabetes mellitus(T2DM)and the underlying regu...
关键词：Type 2 diabetes mellitus Plantamajoside TRANSCRIPTOMICS Islet beta cell injury MIN6 cell Endoplasmic reticulum stress Dnajc1 
2型糖尿病合并亚临床甲状腺功能减退症患者HOMA-IR HOMA-ISLET与TSH水平的关系研究
《河北医学》2025年第1期146-150,共5页高婷婷 周玉荣 葛勇 沈小静 时训婷 
2018年安徽省自然科学基金项目,(编号:1808085MH236)。
目的:探究2型糖尿病合并亚临床甲状腺功能减退症(甲减)患者的胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-ISLET)与促甲状腺激素(TSH)水平的关系。方法:选取102例在我院治疗的2型糖尿病合并亚临床甲减患者,收治时间为2019年10月...
关键词：胰岛素抵抗指数 胰岛β细胞功能指数 促甲状腺激素 亚临床甲状腺功能减退症 
Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine
《Chinese Journal of Integrative Medicine》2025年第1期39-48,共10页WU Wen-bin GAO Fan TANG Yue-heng WANG Hong-zhan DONG Hui LU Fu-er YUAN Fen 
Supported by the National Natural Science Foundation of China(No.82004358)。
Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(...
关键词：type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine 
Advancing type 1 diabetes therapy: autologous islet transplant breakthrough
《Signal Transduction and Targeted Therapy》2025年第1期15-17,共3页Ram Abou Zaki Assam El-Osta 
funded through a strategic research agreement with JDRF International(grant 2-SRA-2024-1442-S-B);received additional support from a grant provided by the Danish Diabetes Academy to AEO,which is financed by the Novo Nordisk Foundation(grant NNF17SA0031406).
The first patient to receive autologous transplantation of chemically induced pluripotent stem-cell-derived islets(CiPSC islets)was recently announced in the journal Cell.The breakthrough surgery by Wang and colleague...
关键词：AUTOLOGOUS ISLET DIABETES 
Relationship between imaging changes of the pancreas and islet beta-cell function
《World Journal of Radiology》2024年第12期717-721,共5页Hong-Jing Chen Yun Hu Jian-Hua Ma 
Imaging changes in the pancreas can provide valuable information about the status of islet beta-cell function in different pancreatic diseases,such as diabetes,pancreatitis,pancreatic cancer,fatty pancreas,and insulin...
关键词：PANCREAS Imaging diagnosis Islet beta-cell function DIABETES PANCREATITIS 
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