ISLET

作品数：202被引量：292H指数：8
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Editorial on amylase and the acini–islet–acinar reflex:A new frontier in metabolic health research
《World Journal of Experimental Medicine》2025年第1期6-10,共5页Opeyemi Deji-Oloruntoba Uchenna E Okpete Haewon Byeon 
Supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287,No.NRF-2021S1A5A8062526;Local Government-University Cooperation-Based Regional Innovation Projects,No.2021RIS-003.
This editorial comments on the study by Pierzynowska et al investigating the acini-islet-acinar(AIA)reflex,which integrates the exocrine and endocrine functions of the pancreas.The study investigates whether exogenous...
关键词：ALPHA-AMYLASE Insulin secretion Glucose metabolism Pancreatic signaling Metabolic regulation Acino-insular axis 
Isletβ-cell function preservation by different anti-diabetic treatments in Chinese elderly patients with type 2 diabetes mellitus
《World Journal of Diabetes》2025年第2期81-91,共11页Wei Ling Yan-Chao Wang Yi Huang Yang-Fu Ou Yan-Chun Jiang 
Medical Ethics Committee of the Nanxishan Hospital of Guangxi Zhuang Autonomous Region(Approval No.NXSYY-2024-209).
BACKGROUND The preservation of isletβ-cell function in elderly patients with type 2 diabetes mellitus(T2DM)is a top priority for diabetic control.AIM To assess the preservation of isletβ-cell function among elderly ...
关键词：Type 2 diabetes Elderly β-Cell function Diabetic treatments 
Plantamajoside improves type 2 diabetes mellitus pancreaticβ-cell damage by inhibiting endoplasmic reticulum stress through Dnajc1 up-regulation
《World Journal of Diabetes》2025年第2期183-196,共14页Duo Wang Yuan-Song Wang Hong-Min Zhao Peng Lu Meng Li Wei Li Huan-Tian Cui Zhong-Yong Zhang Shu-Quan Lv 
Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio,No.4(2022).
BACKGROUND Plantamajoside(PMS)has shown potential in mitigating cell damage caused by high glucose(HG)levels.Despite this,the precise therapeutic effects of PMS on type 2 diabetes mellitus(T2DM)and the underlying regu...
关键词：Type 2 diabetes mellitus Plantamajoside TRANSCRIPTOMICS Islet beta cell injury MIN6 cell Endoplasmic reticulum stress Dnajc1 
2型糖尿病合并亚临床甲状腺功能减退症患者HOMA-IR HOMA-ISLET与TSH水平的关系研究
《河北医学》2025年第1期146-150,共5页高婷婷 周玉荣 葛勇 沈小静 时训婷 
2018年安徽省自然科学基金项目,(编号:1808085MH236)。
目的:探究2型糖尿病合并亚临床甲状腺功能减退症(甲减)患者的胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-ISLET)与促甲状腺激素(TSH)水平的关系。方法:选取102例在我院治疗的2型糖尿病合并亚临床甲减患者,收治时间为2019年10月...
关键词：胰岛素抵抗指数 胰岛β细胞功能指数 促甲状腺激素 亚临床甲状腺功能减退症 
Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine
《Chinese Journal of Integrative Medicine》2025年第1期39-48,共10页WU Wen-bin GAO Fan TANG Yue-heng WANG Hong-zhan DONG Hui LU Fu-er YUAN Fen 
Supported by the National Natural Science Foundation of China(No.82004358)。
Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(...
关键词：type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine 
Advancing type 1 diabetes therapy: autologous islet transplant breakthrough
《Signal Transduction and Targeted Therapy》2025年第1期15-17,共3页Ram Abou Zaki Assam El-Osta 
funded through a strategic research agreement with JDRF International(grant 2-SRA-2024-1442-S-B);received additional support from a grant provided by the Danish Diabetes Academy to AEO,which is financed by the Novo Nordisk Foundation(grant NNF17SA0031406).
The first patient to receive autologous transplantation of chemically induced pluripotent stem-cell-derived islets(CiPSC islets)was recently announced in the journal Cell.The breakthrough surgery by Wang and colleague...
关键词：AUTOLOGOUS ISLET DIABETES 
Relationship between imaging changes of the pancreas and islet beta-cell function
《World Journal of Radiology》2024年第12期717-721,共5页Hong-Jing Chen Yun Hu Jian-Hua Ma 
Imaging changes in the pancreas can provide valuable information about the status of islet beta-cell function in different pancreatic diseases,such as diabetes,pancreatitis,pancreatic cancer,fatty pancreas,and insulin...
关键词：PANCREAS Imaging diagnosis Islet beta-cell function DIABETES PANCREATITIS 
Supragel-mediated efficient generation of pancreatic progenitor clusters and functional glucose-responsive islet-like clusters
《Bioactive Materials》2024年第11期1-14,共14页Hongmeng Ma Lilin Xu Shengjie Wu Songdi Wang Jie Li Sifan Ai Zhuangzhuang Yang Rigen Mo Lei Lin Yan Li Shusen Wang Jie Gao Chen Li Deling Kong 
National Key Technologies Research and Development Program of China(2020YFA0803701);National Natural Science Foundation of China(81921004,T2122019);CAMS Innovation Fund for Medical Sciences(2021–12M-1-052).
Although several synthetic hydrogels with defined stiffness have been developed to facilitate the proliferation and maintenance of human pluripotent stem cells(hPSCs),the influence of biochemical cues in lineage-speci...
关键词：Synthetic hydrogel Stem cell differentiation Mechanical stiffness Islet clusters 
Biomimetic artificial islet model with vascularized microcapsule structures for durable glycemic control
《Materials Futures》2024年第3期157-167,共11页Jingbo Li Yile Fang Zhuhao Wu Luoran Shang Ling Li 
supported by National Natural Science Foundation Major International(Regional)Joint Research Program(82320108003);National Natural Science Foundation(82170845,82000740,81970717);the Key Research&Development Program(No.BE2022853);Medical Key Discipline(ZDXK202203)of Jiangsu Province.
Islet transplantation is a promising strategy for diabetes mellitus treatment as it can recapitulate endogenous insulin secretion and provide long-term glycemic control.Islet models constructed in biomaterial scaffold...
关键词：artificial islet model MICROFLUIDICS VASCULARIZATION hydrogel diabetes 
Amylase intrapancreatic infusion delays insulin release during an intravenous glucose tolerance test,proof of acini–islet–acinar interactions
《World Journal of Experimental Medicine》2024年第3期101-107,共7页Kateryna Pierzynowska Piotr Wychowański Kamil Zaworski Jarosław Woliński Janine Donaldson Dominika Szkopek Katarzyna Roszkowicz-Ostrowska Agata Kondej Stefan G Pierzynowski 
BACKGROUND The possible existence of an acini–islet–acinar(AIA)reflex,involving mutual amylase and insulin interactions,was investigated in the current acute experiment on pigs.AIM To confirm the existence of an AIA...
关键词：AMYLASE Glucose-insulin-amylase interaction Intravenous glucose tolerance test Acini-islet-acinar axis INSULIN 
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