Bone marrow-derived microglia confer neuroprotection to a mouse model of amyotrophic lateral sclerosis  

作　　者：Beka Solomon 

机构地区：[1]Department of Molecular Microbiology and Biotechnology,The Shmunis School of Biomedicine and Cancer Research,the George S.Wise Faculty of Life Sciences Tel-Aviv University,Ramat Aviv,Israel

出　　处：《Neural Regeneration Research》2024年第12期2586-2587,共2页中国神经再生研究（英文版）

摘　　要：Amyotrophic lateral sclerosis(ALS) is a neurodegenerative disease that causes the progressive loss of both upper and lower motor neurons in the brain,brainstem,and spinal cord.The exact mechanisms of ALS are still unclear,but genetic and molecular studies have revealed some key factors that may contribute to motor neuron death.Besides motor neurons,other cell types in the nervous system,such as reactive astrocytes and activated microglia,also show pathological changes and secrete harmful substances and inflammatory cytokines(Appel et al.,2011).

关 键 词：SCLEROSIS BRAINSTEM 

分 类 号：R744.8[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]