Potential Medicinal Value of Rhein for Diabetic Kidney Disease  

作　　者：MAO Xi XU Ding-qiao YUE Shi-jun FU Rui-jia ZHANG Sai TANG Yu-ping 

机构地区：[1]Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility,Shaanxi University of Chinese Medicine,Xi’an,712046,China

出　　处：《Chinese Journal of Integrative Medicine》2023年第10期951-960,共10页中国结合医学杂志（英文版）

基　　金：the National Key R&D Program of China(No.2019YFC1711000);Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019-YL10)。

摘　　要：Diabetic kidney disease(DKD)is the primary cause of mortality among diabetic patients.With the increasing prevalence of diabetes,it has become a major concern around the world.The therapeutic effect of clinical use of drugs is far from expected,and therapy choices to slow the progression of DKD remain restricted.Therefore,research on new drugs and treatments for DKD has been a hot topic in the medical field.It has been found that rhein has the potential to target the pathogenesis of DKD and has a wide range of pharmacological effects on DKD,such as anti-nephritis,decreasing blood glucose,controlling blood lipids and renal protection.In recent years,the medical value of rhein in the treatment of diabetes,DKD and renal disease has gradually attracted worldwide attention,especially its potential in the treatment of DKD.Currently,DKD can only be treated with medications from a single symptom and are accompanied by adverse effects,while rhein improves DKD with a multi-pathway and multi-target approach.Therefore,this paper reviews the therapeutic effects of rhein on DKD,and proposes solutions to the limitations of rhein itself,in order to provide valuable references for the clinical application of rhein in DKD and the development of new drugs.

关 键 词：RHEIN diabetic kidney disease rhein derivatives TOXICITY BIOAVAILABILITY 

分 类 号：R285[医药卫生—中药学]